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Abstract Conventional type I dendritic cells (cDC1s) undergo homeostatic maturation upon apoptotic cell engulfment, hallmarked by the activation of the transcription factor LXRβ, which mediates cholesterol efflux and dampens interferon-stimulated gene expression. Here, we identify the unfolded protein response sensor IRE1 as an essential regulator of this process. Loss of IRE1 impairs cDC1, but not cDC2, homeostatic maturation and survival.
Keywords lymph node fibroblastic reticular cells dendritic cells Notch signaling CD8+ T memory precursor cells T cell zone compartmentalization Ccl19 Ccr7 secondary lymphoid organs homeostasis Introduction Secondary lymphoid organs (SLOs) such as lymph nodes (LNs), Peyer’s patches (PPs), and spleen are strategically positioned to filter local body fluids and function as sites of antigen-specific T and B lymphocyte activation against pathogens and cancer.
Un ours en peluche cousu main Répondant au doux nom de Basile, cet ours en peluche semble tout droit sorti du placard de nos grands-parents… Et pourtant ! Il est en fait issu de l’imagination d’une créatrice inspirée par le concours Marie Claire Idées sur le thème des ours. Grâce à ses membres articulés, il a pu enfiler un joli pull over tricoté à la main et n’aura pas froid cet hiver.
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