Eric Perkey

1Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA 3Department of Immunobiology, University of Lausanne, Epalinges, Switzerland 4Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA 5Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA 6Children’s Hospital of Philadelphia,...

1Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA 3Department of Immunobiology, University of Lausanne, Epalinges, Switzerland 4Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA 5Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA 6Children’s Hospital of Philadelphia,...

Highlights • Single-cell RNA-seq reveals CD19 expression in human brain mural cells • Mural cells line blood vessels and maintain blood-brain barrier integrity • Brain mural cell CD19 expression is present across brain regions and human age • Targeting CD19+ mural cells may contribute to neurotoxicity of CAR-T therapy Summary CD19-directed immunotherapies are clinically effective for treating B cell malignancies but also cause a high incidence of neurotoxicity.