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Articles by Sapna Devi
Cecelia: a multifunctional image analysis toolbox for decoding spatial cellular interactions and behaviour
Abstract With the ever-increasing complexity of microscopy modalities, it is imperative to have computational workflows that allow researchers to process and perform in-depth quantitative analysis of the resulting images. However, workflows that enable flexible, interactive and intuitive analysis from raw images to analysed data are lacking.
I’m feeling 22
Sapna Devi · Follow 5 min read · Jul 4, 2023 -- I don’t know about you, but I’m feeling 22! I’m not a fan of birthday celebrations, instead, I prefer to retreat into a chamber of reflection.
CD8+ and CD4+ T Cells Infiltrate into the Brain during Plasmodium berghei ANKA Infection and Form Long-Term Resident Memory
Nazanin Ghazanfari, Julia L. Gregory, Sapna Devi, Daniel Fernandez-Ruiz, Lynette Beattie, Scott N. Mueller and William R. Heath J Immunol September 15, 2021, 207 (6) 1578-1590; DOI: https://doi.org/10.4049/jimmunol.2000773 Key Points Malaria-specific T cells can enter the brain parenchyma near the onset of ECM. Infiltration of T cells into the brain parenchyma contributes to cerebral pathology. Memory T cells can form within the brain parenchyma after malaria infection.
Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses
Highlights • Activation of the sympathetic nervous system halts leukocyte locomotion in tissues • Noradrenaline induces adrenergic receptor signaling to reduce lymph node blood flow • Decreased tissue oxygenation induces calcium signaling to control leukocyte motility • Disruption of leukocyte motility contributes to impaired immune responses Summary The sympathetic nervous system (SNS) controls various physiological functions via the neurotransmitter noradrenaline.
Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection
Highlights • Systemic coinfection impairs the induction of immunity during local infection • Systemic coinfection impairs stromal cell expansion in draining lymph nodes (dLN) • Systemic coinfection suppresses B cell responses and antibody production • Sequestration of lymphocytes in distal LN constrains immunity in dLNs Summary Concurrent infection with multiple pathogens occurs frequently in individuals and can result in exacerbated infections and altered immunity.
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