Sarah Cobey on Muck Rack

Sarah Cobey

University of Chicago
As seen in: The New York Times, The New York Times en Español, Nature, Science Magazine, Business Standard, Cell Press, Genetic Literacy Project, Revista de Prensa "Almendrón"
Professor at U. Chicago. @cobey.bsky.social
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Articles

Cross-reactive human antibody responses to H5N1 influenza virus neuraminidase are shaped by immune history

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By Jordan T. Ort, Ashley Leonard, Shuk Hang Li, Reilly K. Atkinson, Lydia Mendoza, Marcos Vieira, Sydney Gang, Sarah Cobey, Scott Hensley Verified
| Nature Verified
Abstract H5N1 highly pathogenic avian influenza viruses have spread globally and pose a pandemic risk. Prior studies suggest that early life exposures to group 1 influenza viruses (H1N1 and H2N2) prime antibodies that cross-react to the hemagglutinin of H5N1, which is also a group 1 virus. However, less is known about how immune history affects antibody responses against the H5N1 neuraminidase (NA).
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Immune history shapes human antibody responses to H5N1 influenza viruses - Nature Medicine

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By Shuk Hang Li, Gabrielle Scher, Naiqing Ye, Jordan T. Ort, David Schultz, Sara Cherry, Sarah Cobey
| Nature Verified
Abstract Avian H5N1 influenza viruses are circulating widely in cattle and other mammals and pose a risk for a human pandemic. Previous studies suggest that older humans are more resistant to H5N1 infections due to childhood imprinting with other group 1 viruses (H1N1 and H2N2); however, the immunological basis for this is incompletely understood. Here we measured H5N1 antibody responses in sera from 157 individuals born between 1927 and 2016.
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The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus - Nature Communications

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By Adam S. Lauring, Sarah Cobey, Jessica C. Ibiebele
| Nature Verified
Abstract The role of viral interaction—where one virus enhances or inhibits infection with another virus—in respiratory virus transmission is not well characterized. This study used data from 4029 total participants from 957 households who participated in a prospective household cohort study in Southeast Michigan, U.S.A to examine how viral coinfection and cocirculation may impact transmission of symptomatic influenza and respiratory syncytial virus infections.
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