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Sarah Graff on Muck Rack

Sarah Graff

As seen in: Nature, Wiley Online Library, MDPI, BioRxiv, Cell Reports, Annual Reviews Journal, Diabetes Magazine, Lamorinda Weekly
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Articles

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

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By Apoorva Uboveja, Raquel Buj, Amandine Amalric, Hui Wang, Naveen Kumar Tangudu, Aidan Cole, Richard Fang, Miho Naruse, Zhentai Huang, Emily Megill, Daniel S. Kantner, Adam Chatoff, Hafsah Ahmad, Mariola M. Marcinkiewicz, Sarah Graff, Ellen De Pieri, Frank P. Vendetti, Jeff Danielson, Erika Dahl, Jennifer Pennise, Alison Jaccard, Kristine Cooper, Francesmary Modugno, Nadine Hempel, Wayne Stallaert, Christopher J. Bakkenist, Simone Sidoli, Kathryn Wellen, Benjamin G. Bitler, David Long, Nathaniel W Snyder, Katherine M. Aird, Baixue Yang, Julie A. Disharoon, Evan Levasseur, Andrea Andress Huacachino, Esther Elishaev, Lauren Borho
| Nature Verified
Abstract Homologous recombination (HR) deficiency increases sensitivity to DNA-damaging agents that are commonly used to treat cancer1. In HR-proficient cancers, the metabolic mechanisms that drive response or resistance to DNA-damaging agents remain unclear. Here we have identified that depletion of α-ketoglutarate (αKG) sensitizes HR-proficient cells to DNA-damaging agents by metabolic regulation of histone acetylation.
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Preliminary Evidence for Increased Histone Succinylation as a Potential Epigenetic Marker for Longevity

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By Stephanie Stransky, Sarah Graff, Kai Mao, Derek M. Huffman
| Wiley Online Library Verified
Aging is a complex biological process marked by a progressive decline in cellular and tissue function, increasing susceptibility to cancer, cardiovascular disease, and neurodegenerative disorders (Guo et al. 2022). Among the molecular hallmarks of aging, epigenetic alterations are thought to play a pivotal role in mediating these age-related phenotypic changes (López-Otín et al. 2023).
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Beating Cardiac Cell Cultures From Different Developmental Stages of Rainbow Trout as a Novel Approach for Replication of Cardiac Fish Viruses

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By Torben Krebs, Julia Bauer, Sarah Graff, Lukas Teich
| Wiley Online Library Verified
1 Introduction Viral diseases in farmed aquatic animals are characterised by a high prevalence of infections, which can lead to high mortality rates and the need for specific treatments. These diseases have resulted in significant economic losses and impediments to large-scale aquaculture globally (Adamek et al. 2019; Dixon et al. 2016; He, Ding, and He 2021).
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