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Scott B. Rothbart on Muck Rack

Scott B. Rothbart

As seen in: Nature, Science Magazine, BioRxiv, Cell Press, Journal of Chemical Physics, Cancer Discovery, The Journal of Biological Chemistry
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Articles

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

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By Xiangqian Kong, Jie Chen, Wenbing Xie, Stephen Brown, Yi Cai, Kaichun Wu, Daiming Fan, Yongzhan Nie, Srinivasan Yegnasubramanian, Rochelle L Tiedemann, Yong Tao, Ray-Whay Chiu Yen, Michael J. Topper, Cynthia A. Zahnow, Hariharan Easwaran, Scott B. Rothbart, Limin Xia, Stephen B. Baylin
| Cell Press Verified
Main text (Cancer Cell , 633–648.e1–e7; April 15, 2019) We, the authors of this article, described that UHRF1 maintains cancer-specific DNA methylation in colorectal cancer through its histone and hemimethylated DNA binding functions. In the original publication, the antibody used to detect p16-INK4a () by western blot in Figure S4F was incorrectly listed as Abcam ab51243. This antibody is specific to p16-ARC () and does not cross-react with p16-INK4a/CDKN2A.
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The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer

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By Jakob Hebert, Rochelle L Tiedemann, Qingzeng Gao, Yang Xiao, Nicholas Prescott, Yanqing Liu, Ryan Bastle, Aarthi Ramakrishnan, Ian Maze, Simone Sidoli, Richard P. Koche, Karuna Ganesh, Scott B. Rothbart, Yael David, Ifé Akano
| Cell Press Verified
1Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA 2Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA 3Tri-Institutional PhD Program in Chemical Biology, New York, NY, USA 4Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA 5Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA 6Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY, USA 7Department...
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Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation - Nature Communications

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By Kendra R. Vann, Maëva Devoucoux, Lei Zeng, Lorena Alamillo, Jianlong Wang, Brian D. Strahl, Scott B. Rothbart, Martin Walsh, Michael Cleary, Jacques Côté, Xiaobing Shi, Ming-Ming Zhou
| Nature Verified
Abstract The histone H3K36-specific methyltransferase ASH1L plays a critical role in development and is frequently dysregulated in human diseases, particularly cancer. Here, we report on the biological functions of the C-terminal region of ASH1L encompassing a bromodomain (ASH1LBD), a plant homeodomain (ASH1LPHD) finger, and a bromo-adjacent homology (ASH1LBAH) domain, structurally characterize these domains, describe their mechanisms of action, and explore functional crosstalk between them.
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