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Xinlan Wen

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Articles

Physiological brain clearance architecture revealed by neuronal protein tracing

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By Yuichi Chayama, Nalini Rao, Daniela Perla, Zimo Zhang, Madigan Reid, Sophia Nelson, Xinlan Wen, Bella Ding, Jessica Blumenfeld, Amanda Apolonio, Sahith Doddipalli, Haoyue Zhou, Sena Gül Turhan, Pu-Yun Shih, Matthias Brendel, Ying-Hui Fu, Ali Erturk, Zeynep Ilgin Kolabas, Yadong Huang, Andrew Yang
| Cell Press Verified
Keywords brain waste clearance brain borders CNS drainage cerebrospinal fluid neuroimmunology Alzheimer’s disease dura skull immune tolerance Introduction The brain’s high metabolic activity produces waste that must be continuously cleared to maintain neural function and homeostasis.1,2,3 In the absence of a conventional lymphatic system, the central nervous system (CNS) relies on a complex network involving cerebrospinal fluid (CSF), perivascular spaces, and meningeal pathways to manage...
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