Ying-Hui Fu

Keywords brain waste clearance brain borders CNS drainage cerebrospinal fluid neuroimmunology Alzheimer’s disease dura skull immune tolerance Introduction The brain’s high metabolic activity produces waste that must be continuously cleared to maintain neural function and homeostasis.1,2,3 In the absence of a conventional lymphatic system, the central nervous system (CNS) relies on a complex network involving cerebrospinal fluid (CSF), perivascular spaces, and meningeal pathways to manage...

Keywords circadian clock circadian rhythm proteome analysis phosphorylation nuclear localization mass spectrometry Introduction The circadian clock is an endogenous self-sustained oscillator that drives daily rhythms of metabolism and physiology.1,2 In mammals, the suprachiasmatic nucleus (SCN), known as the central clock, synchronizes the temporal rhythms of peripheral tissues.

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