Allen Wang

Abstract Fentanyl, an opioid medication commonly given to hospitalized preterm infants, may alter gut microbiome development and subsequent neurodevelopmental outcomes. We compare a cohort of preterm infants with and without postnatal fentanyl exposure, using their hospitalization stool samples and neurodevelopmental outcomes. The study examines the association between fentanyl exposure, fecal microbiome differences during NICU stay, and neurodevelopmental outcomes up to age 8.

STAR★Methods REAGENT or RESOURCESOURCEIDENTIFIER Chemicals, peptides, and recombinant proteins Tn5 transposase QB3 Macrolab at UC Berkeley N/A SPRISelect reagent Beckman Coulter Cat# B23319 DRAQ7 Cell Signaling Cat# 7406 NEBNext High-Fidelity PCR Master Mix NEB Cat# M0541L LightCycler 480 SYBR Green I Master Mix Roche Cat# 04707516001 DTT nuclei permeabilization buffer Sigma-Aldrich Cat# 646563-10X IGEPAL-CA630 Sigma-Aldrich Cat#I8896 1X cOmplete EDTA-free protease inhibitor cocktail tablets...

The U.S. Patent and Trademark Office (USPTO) is making it easier to get patents for transformative technology. Over the past decade, the USPTO has rejected growing numbers of patent applications, covering a variety of software from fintech to social networking to machine learning, under § 101 as abstract and patent-ineligible. That landscape is now shifting. What is the USPTO’s New Approach to Patent Eligibility?