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April Williams

As seen in: Nature, Wiley Online Library, BioRxiv, Cell Stem Cell, WRC-TV (Washington, DC), MDEdge, The Courier-Times
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Articles

Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling that associates with impaired function of neighboring T cells

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By Armin Gandhi, Kathryn Lande, Kelly Li, Michael LaPorte, K. Garrett Evensen, Marcos Garcia Teneche, Rouven Arnold, Adarsh Rajesh, Jessica Proulx, Shanshan Yin, Aaron Havas, Angela Y. Liou, Allen Lee, Helene Martini, Xue Lei, Charlene Miciano, Qian Yang, Sainath Mamde, Andrew Davis, Rebecca A. Porritt, Alessandra Sacco, João F. Passos, Kevin Tharp, Kevin Y. Yip, Allen Wang, Bing Ren, April Williams, Susan M Kaech, Peter Adams, Filipe A. Hoffmann, Shirong Tan, Benji Portillo, Elizabeth W. Smoot
| Nature Verified
Abstract Liver cancer incidences increase dramatically beyond 55 years of age, suggesting that age-associated changes contribute critically to tumor initiation. However, the mechanisms linking liver aging and cancer initiation remain incompletely defined. This study investigated the role of CD44, a marker of liver tumor-initiating cells (TICs), in age-associated liver pathophysiology.
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Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis

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By Victoria Osorio-Vasquez, Jonathan Zhu, Jan Lumibao, Kathryn Lande, Kristina Peck, Shira R Okhovat, Hyemin Song, Satoshi Ogawa, Casie S Kubota, Vasiliki Pantazopoulou, Yang Dai, Angelica Rock, Ethan Thomas, Jasper Hsu, Alexandra Fowler, K. Garrett Evensen, April Williams, Siri Larsen, Phil Greer, Jessica Gibson, Michael Downes, Ronald Evans, Andrew M. Lowy, David C. Whitcomb, Jingjing Zou, Alfredo A. Molinolo, Rebekah White Verified, Melena D Bellin, Hervé Tiriac, Dannielle D. Engle, McKenna K. Stamp, Kassidy Curtis, Kahing Kuo, Chelsea R. Bottomley, Araceli Herrera Morales, T’onj McGriff, Muhamad Abdulla
| Cell Stem Cell Verified
ArticleOnline nowOpen access Affiliations & Notes 1Salk Institute for Biological Studies, La Jolla, CA 92037, USA 2Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA 3Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA 4Schulze Diabetes Institute, Department of Surgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA 5Ariel Precision Medicine, Pittsburgh, PA 15206, USA 6Department of Surgery, Division of...
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ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation

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By Sanjeeb Kumar Sahu, Sebastian Memczak, Sudhir Thakurela, Jinlong Y. Lu, Priya Gupta, Yingzi Zhang, Tomoaki Hishida, Masakazu Kurita, Chao Wang, Yanjiao Shao, April Williams, Vijay K Tiwari, Concepcion Rodriguez Esteban, Pradeep Reddy, Alexander Meissner, Mo Li, Naresh Mutukula, Alex Hirano, Max Shokhirev
| Cell Stem Cell Verified
Keywords genome integrity DNA repair senescence senescence-associated secretory phenotype SASP inflammation CRISPR-Cas9 screening ZNF512B chromatin remodeling amyotrophic lateral sclerosis neuromuscular organoids Get full text access Log in, subscribe or purchase for full access. References 1. Di Micco, R. ∙ Krizhanovsky, V. ∙ Baker, D. ... Cellular senescence in ageing: from mechanisms to therapeutic opportunities Nat. Rev. Mol. Cell Biol. 2021; 22:75-95 2. Eggert, T. ∙ Wolter, K. ∙ Ji, J. ...
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