Skip To Main Content
Shea Lowery on Muck Rack

Shea Lowery

As seen in: Nature, PNAS, BioRxiv, Cell Host & Microbe, The Journal of Biological Chemistry

Get in touch with Shea

Contact Shea, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Articles

Longitudinal analysis reveals myeloid cell contributions to murine neuroPASC pathogenesis

|
By Lu Tan, ABHISHEK VERMA, Shea Lowery, Andrew Thurman, Alan Sariol, Cori E. Fain, Zhaoyuan Liu, Florent Ginhoux, John Harty, David Meyerholz, Stanley Perlman
| Nature Verified
Abstract Neurological and neuropsychiatric symptoms, collectively termed neuroPASC, are among the most prevalent Post-Acute Sequelae of COVID-19 (PASC). Neuroinflammation – particularly microglia reactivity – has been implicated in neuroPASC. We previously established a PASC model in which SARS-CoV-2-infected mice developed persistent behavior alterations and prolonged neuroinflammation for up to 120 days post-infection (dpi).
Open in Who Shared Issue with article?

Persistent Neurological Deficits in Mouse PASC Reveal Antiviral Drug Limitations

|
By ABHISHEK VERMA, Shea Lowery, Li-Chin Lin, Eazhisaivallabi Duraisami
| BioRxiv
Abstract Post-Acute Sequelae of COVID-19 (PASC) encompasses persistent neurological symptoms, including olfactory and autonomic dysfunction. Here, we report chronic neurological dysfunction in mice infected with a virulent mouse-adapted SARS-CoV-2 that does not infect the brain. Long after recovery from nasal infection, we observed loss of tyrosine hydroxylase (TH) expression in olfactory bulb glomeruli and neurotransmitter levels in the substantia nigra (SN) persisted.
Open in Who Shared Issue with article?

A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein

|
By Dene R. Littler, Miaomiao Liu, Julie McAuley, Shea Lowery
| The Journal of Biological Chemistry Verified
The Nsp9 replicase is a conserved coronaviral protein that acts as an essential accessory component of the multi-subunit viral replication/transcription complex. Nsp9 is the predominant substrate for the essential nucleotidylation activity of Nsp12. Compounds specifically interfering with this viral activity would facilitate its study.
Open in Who Shared Issue with article?
See all 6 articles