Shi Chen
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Articles by Shi Chen
Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing Original
Abstract Diabetic foot infection (DFI) significantly increases the risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Escherichia coli (CREC) being key drivers of treatment failure. Here, we analyzed MRSA/CREC biofilm-infected ulcer tissues from patients using proteomics and metabolomics.
Evaluation of Time of Linkage to Care Among Newly Diagnosed People with HIV in Mecklenburg County, North Carolina, United States, 2013–2019
Introduction Linkage to care (LtC) is the successful completion of a visit with a human immunodeficiency virus (HIV) medical provider within 1 month (30 days) of HIV diagnosis.1 Timely LtC after HIV diagnosis is critical to achieve optimal treatment outcomes and prevent ongoing transmission.2–5 Conversely, delayed LtC has been associated with delayed initiation of antiretroviral therapy (ART), which may lead to delayed viral suppression.6,7 Approximately 80% of people living with HIV (PWH) in...
Serum metabolomic signatures associated with growth hormone replacement therapy in children with postoperative craniopharyngioma
Abstract Growth hormone replacement therapy (GHRT) is commonly used to treat growth hormone deficiency (GHD) after craniopharyngioma (CP) surgery, but its metabolic consequences in pediatric patients remain incompletely characterized. This study aimed to investigate serum metabolomic alterations associated with GHRT in pediatric patients with postoperative childhood-onset CP.
Exploration of the population size of men who have sex with men in Hainan colleges: A cross-sectional study based on geographical social network App
Loading metrics Open Access Peer-reviewed Research Article Citation: Chen S, Chen X, Feng R, Chen G, Lu C, Zhao D, et al. (2026) Exploration of the population size of men who have sex with men in Hainan colleges: A cross-sectional study based on geographical social network App. PLoS One 21(9): e0358788.
Urban spatial structure and ecological resilience in China
Abstract As urbanization accelerates and cities continuously expand and reshape their built environments, understanding the impact of urban spatial structure on ecological resilience has become increasingly crucial for promoting sustainable urban development.
Peer victimization and school refusal tendencies in early adolescence: A random intercept cross-lagged panel model analysis
CONFLICT OF INTEREST STATEMENT Authors have no conflicts of interest to disclose. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. REFERENCES (2004). Bully/victim problems and their association with Machiavellianism and self-efficacy in Greek primary school children. British Journal of Educational Psychology, 74(2), 297–309.
Computer Science > Human-Computer Interaction
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KRAS G12D inhibition reprograms the tumor-induced immunosuppressive environment and enhances NK cell–mediated antitumor immunity
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract KRASG12D mutation drives oncogenic progression and creates an immunosuppressive microenvironment in cancers like pancreatic ductal adenocarcinoma and colorectal cancer.
By Rui Yang, Ying Yuan, Amaia Ochandorena-Saa, Tuo Hu, Taiwei Mo, Lin Wang, Qiuqing Ke, Liangjie Chi, Hongyuan Chen, Chao Xu, Chenshen Huang, Aiping Lin, Shaoxin Cai, Haiyu Chen, Wenyu Wang, Longyang Jin, Haoyun Liu, Chuanyuan Liu, Abudumaimaitijiang Tuersun, Yan Zheng, Zuwei Wang, Shi Chen, Junzhang Zhao, Yimamu Baihetiyaer, Abuduhalike Abulimiti
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Science Magazine
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Crotonylation of ACAT1 K181 contributes to radioresistance by impacting lactate metabolism
Abstract Ionizing radiation (IR)-induced alterations in glucose metabolism are closely associated with radioresistance, yet the underlying mechanisms remain incompletely understood.
Resolving Nitrous Oxide Source Ambiguity in Ammonia-Oxidizing Archaea-Dominated Nitrification: Mechanistic Modeling of the Hybrid Pathway and Coupled Denitrification Click to copy article link Article link copied!
Cite Jump to ExpandCollapse Energy and ClimateJuly 14, 2026 Resolving Nitrous Oxide Source Ambiguity in Ammonia-Oxidizing Archaea-Dominated Nitrification: Mechanistic Modeling of the Hybrid Pathway and Coupled Denitrification Click to copy article linkArticle link copied! Shi Chen Shi Chen Key Laboratory of Green Utilization of Critical Non-Metallic Mineral Resources, Ministry of Education, Wuhan University of Technology, Wuhan 430070, China Shenzhen Research Institute of Wuhan University of...
Thrombospondin-4 Regulates Lipopolysaccharide-Induced Apoptosis and Inflammation in Nucleus Pulposus Cells via the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
1 Introduction Intervertebral disc degeneration (IDD) is a major cause of chronic lower back pain with a steadily rising prevalence, posing a significant global health challenge that compromises work capacity and quality of life [1, 2]. Currently, there are no effective clinical interventions to reverse IDD progression, primarily because of the lack of evident early symptoms and an incomplete understanding of its molecular pathogenesis [3].
Pour climate risk on corporate debt maturity mismatch: moderation role of formal and informal institution
Abstract Against worsening global climate change, growing climate risk uncertainty severely challenges firms’ capital activities. This paper theoretically analyzes climate risk’s effect on corporate debt maturity mismatch (CDM), its mechanisms and heterogeneity.
An siENPP1-Delivering Bimetallic MOF Nanocomplex Enables Triple Activation of the cGAS-STING Pathway for Synergistic Triple-Negative Breast Cancer Therapy
, , , et al. “An siENPP1-Delivering Bimetallic MOF Nanocomplex Enables Triple Activation of the cGAS-STING Pathway for Synergistic Triple-Negative Breast Cancer Therapy.” Advanced Materials (2026): e73878. https://doi.org/10.1002/adma.73878 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
From Isolation to Integration: The Legacy of Treaty Ports on Inter-City Connectivity
, , and . 2026. “From Isolation to Integration: The Legacy of Treaty Ports on Inter-City Connectivity.” Journal of Regional Science0: 1–21. https://doi.org/10.1111/jors.70073. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. References , , and . 2019.
Continuous Skeletal Muscle Gauge Enhances Preoperative Risk Stratification in Intrahepatic Cholangiocarcinoma: A Multicenter Study
Keywords Intrahepatic cholangiocarcinoma Sarcopenia Skeletal muscle density Skeletal muscle gauge Get full text access Log in, subscribe or purchase for full access. References 1. Moris, D. ∙ Palta, M. ∙ Kim, C. ... Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of the current and future therapeutic landscape for clinicians CA Cancer J Clin. 2023; 73:198-222 2. Alvaro, D. ∙ Gores, G.J. ∙ Walicki, J. ...
Dynamic Topic Alignment and Sentiment between Official Health Communication and General Public Discourse during COVID-19: A Comprehensive Infoveillance Framework
The authors have declared no competing interest. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Agricultural soil microbiomes are structurally and functionally more resistant to warming than adjacent natural ecosystems
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Abstract Agricultural soil microbiomes experience frequent disturbance from intensive management and may therefore be better equipped to withstand climate warming than microbiomes in undisturbed natural soils. Here we test this by combining a continental-scale warming microcosm experiment across 100 paired agricultural–natural sites with a global meta-analysis and three microbiome manipulation experiments (microbial suspensions, cross-inoculation and synthetic communities).
By Shuo Jiao, Haibo Pan, Pablo García-Palacios, Yiran Zhang, Yu Chi Liu, Hang Gao, Beibei Chen, Ziheng Peng, Shi Chen, Jiejun Qi, Chunling Liang, Xiaomeng Li, Yang Wang, Min Gao, Jiai Liu, Yihe Wang, Junhui Zhao, Lan Jiang, Ferran Romero, Samiran Banerjee, Yunfeng Yang, Yahai Lu, Manuel Delgado-Baquerizo, Marcel G. A. van der Heijden, Gehong Wei, Hairong Tu, Chujie Jin
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Nature
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A machine vision based defect detection method for coated carbide CNC inserts and its industrial automation implementation analysis
Abstract Computer Numerical Control (CNC) inserts are critical components of CNC machine tools, where surface defects can severely compromise machining precision. Traditional manual inspection methods for these defects are inefficient and prone to significant oversight. To address these limitations, this paper presents an automated real-time system for detecting surface defects on inserts. A dedicated dataset of CNC tool inserts was created and annotated with defect categories.
Su1124 DECLINING EOSINOPHILIC ESOPHAGITIS DISEASE SEVERITY OVER TIME PARALLELS REDUCED DIAGNOSTIC DELAY
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Mo1159 ANAPHYLAXIS HISTORY AND EPINEPHRINE-PEN PRESCRIPTION IMPACTS PRESENTATION AND TREATMENT OUTCOMES OF EOSINOPHILIC ESOPHAGITIS
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Homogenizing interfacial assembly via indole-mediated binary monolayers for perovskite solar cells
Abstract Self-assembled monolayers (SAMs) have emerged as efficient hole-transport layers for inverted perovskite solar cells (PSCs), yet molecular self-aggregation during assembly limits interfacial homogeneity and device performance. Here we report an indole-carbazole co-adsorption strategy by incorporating N-indoleacetic acid (Nd) into (4-(3,6-diphenyl-9H-carbazol-9-yl)butyl)phosphonic acid (Ph-4PACz) to construct phase-homogeneous monolayers.
Dual cytosine modification through hydroxylation and arabinofuranosylation in phages
Abstract Bacteriophages use diverse genomic modifications, including substitutions on the cytosine pyrimidine ring through C–C and C–N bonds. Here, we report that coliphage HY126 encodes an Afh system with enzymatic activities not previously implicated in DNA modification.
Elevated pulmonary vascular resistance is associated with acute exacerbation admission in patients with chronic obstructive pulmonary disease-related pulmonary hypertension
Keywords chronic obstructive pulmonary disease pulmonary hypertension pulmonary vascular resistance acute exacerbation admission independent predictor Get full text access Log in, subscribe or purchase for full access. References 1. Christenson, S.A. ∙ Smith, B.M. ∙ Bafadhel, M. ... Chronic obstructive pulmonary disease Lancet. 2022; 399(10342):2227-2242 2. Xu, J. ∙ Zeng, Q. ∙ Li, S. ... Inflammation mechanism and research progress of COPD Front Immunol. 2024; 15, 1404615 3. Gan, L. ∙ He, X. ∙ Wu, J.
Rapid concerted switching of the neural code in the inferotemporal cortex
Abstract A fundamental paradigm in neuroscience is that neurons represent the world through fixed tuning functions, with stable mappings from stimulus features to firing rates1. Here, we report that tuning can instead shift rapidly and coherently across a neural population, enabling a dynamic transition from detecting a broad category to discriminating individual exemplars.
Structural Elucidation and Engineering of the ( S )-scoulerine 2- O -Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis
1 Introduction Medicinal plants have served as crucial components of traditional Chinese medicine (TCM) for millennia due to their abundant natural products (Boy et al. 2018). With advances in modern analytical chemistry and biotechnology, numerous bioactive natural compounds have been discovered and identified, revealing the key material foundation for the therapeutic efficacy of medicinal herbs (Sun and Shahrajabian 2023).
Familial Atrial Fibrillation with Short QT Syndrome and Left Atrial Appendage Agenesis: A KCNQ1 Mutation Triad?
Key words familial atrial fibrillation left atrial appendage short QT syndrome KCNQ1 gene Get full text access Log in, subscribe or purchase for full access. Reference: 1. Wang, Y. ∙ Eldstrom, J. ∙ Fedida, D. Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel Complexes Front Physiol. 2020; 11:504 2. Sarquella-Brugada, G. ∙ Campuzano, O. ∙ Iglesias, A. ... Short QT and atrial fibrillation: A KCNQ1 mutation-specific disease. Late follow-up in three unrelated children HeartRhythm Case Rep.
Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma - Nature Communications
Abstract Glioblastoma (GBM) is an incurable brain tumor characterized by high heterogeneity. Oncolytic viruses (OVs) are an approved therapy, but their efficacy is often limited by poor cellular permissiveness to infection. Here we screen bioactive compounds to identify enhancers of oncolytic herpes simplex virus (oHSV) in GBM and discover a brain-penetrant leucine-rich repeat kinase 2 (LRRK2) inhibitor as the strongest sensitizer.
Progressive multifocal leukoencephalopathy as the initial manifestation of relapsed lymphoma: a case report
Abstract Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal demyelinating disease of the central nervous system (CNS) caused by the reactivation of the JC polyomavirus (JCPyV). While PML is a known complication of hematological malignancies, it is exceedingly rare for it to manifest as the initial neurological symptom of a relapsed lymphoma, occurring even before the start of new systemic chemotherapy.
Ultra-performance Liquid Chromatography-mass Spectrometry-based metabolic profiling of prepubertal children with Turner syndrome - Pediatric Research
Abstract This research aims to characterize the metabolic profiles of prepubertal patients with TS to elucidate the potential impact of X chromosome haploinsufficiency on glycolipid metabolism. Fouty-nine prepuberty TS and 50 age-, sex- and BMI standard deviations scores (SDS)-matched healthy children (HC) were enrolled. Untargeted ultra-performance liquid chromatography–coupled mass spectroscopy was performed in all participants.
Understanding Nursing Students' Job Preferences: Insights From a Global Systematic Review With Implications for Healthcare System Recruitment
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analysed during the current study. Supporting Information Filename Description wvn70083-sup-0001-Supinfo1.docxWord 2007 document , 104 KB Data S1: Supporting Information. References , , and . 2022.
Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy
1 Introduction Chronic allograft vasculopathy (CAV) represents a form of immune-mediated allograft injury that occurs in transplanted kidneys during chronic rejection. CAV represents a localized manifestation of chronic rejection that affects the arteries of transplanted kidneys and serves as a hallmark histopathological feature of chronic rejection in all vascularized transplants.
Institutional Openness and Corporate Uncertainty Perception-Insights From Free Trade Zones in China
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. References , , and . 2019. “Performance of the Firms in a Free-Trade Zone: The Role of Institutional Factors and Resources.” European Management Review 16, no. 2: 363–378. https://doi.org/10.1111/emre.12163. 1999.
Disentangling Hardness from Noise: An Uncertainty-Driven Model-Agnostic Framework for Long-Tailed Remote Sensing Classification
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
The Ppl protein senses 3′-hydroxyl DNA overhangs and NTP depletion to halt phage infection
Keywords antiphagy defense system Ppl abortive infection exonuclease endonuclease NTP pool cell dormancy Get full text access Log in, subscribe or purchase for full access. References 1. Hampton, H.G. ∙ Watson, B.N.J. ∙ Fineran, P.C. The arms race between bacteria and their phage foes Nature. 2020; 577:327-336 2. Xiong, X. ∙ Wu, G. ∙ Wei, Y. ... SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities Nat. Microbiol. 2020; 5:917-928 3. Xiong, L. ∙ Liu, S.
The Ppl protein senses 3′-hydroxyl DNA overhangs and NTP depletion to halt phage infection
Keywords antiphagy defense system Ppl abortive infection exonuclease endonuclease NTP pool cell dormancy Get full text access Log in, subscribe or purchase for full access. References 1. Hampton, H.G. ∙ Watson, B.N.J. ∙ Fineran, P.C. The arms race between bacteria and their phage foes Nature. 2020; 577:327-336 2. Xiong, X. ∙ Wu, G. ∙ Wei, Y. ... SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities Nat. Microbiol. 2020; 5:917-928 3. Xiong, L. ∙ Liu, S.
Parents' Perspective on Fertility Preservation of Adolescent Cancer Patients: A Meta‐Synthesis of Qualitative Studies
Objective This study aims to integrate existing qualitative research, consolidate the dynamic experiences of parents of adolescent cancer patients regarding fertility preservation (FP), and highlight the influencing factors of parents' decisions on FP. Methods The following 11 databases, namely PubMed, Web of Science, Embase, PsycINFO, CINAHL, The Cochrane Library, WanFang, VIP, SinoMed, CNKI and OpenGrey, were searched for materials published up to November 2024.
Green path without waste: zero-waste city pilot construction and corporate green innovation - Humanities and Social Sciences Communications
Abstract Using the Zero-Waste City Pilot (ZWCP) as a quasi-natural experiment, this paper applies a standard Difference-in-Differences (DID) approach to evaluate its effect on corporate green innovation (CGI), drawing on the panel data from Chinese A-share listed manufacturing firms between 2012 and 2022. The findings show that the ZWCP significantly promotes green innovation, mainly by improving firms’ internal capabilities and external incentives.
Nursing Students' Perceptions and Attitudes on the Application of Artificial Intelligence in Nursing Education: A Mixed‐Methods Systematic Review
Background The utilisation of artificial intelligence in the context of nursing education has become increasingly extensive. However, various studies show differing perspectives and attitudes among nursing students, and the findings have not been systematically synthesised. Aim To systematically review the perceptions and attitudes of nursing students on the application of artificial intelligence in nursing education. Design Mixed-methods systematic review.
SPHK1-mediated M2 macrophage polarization drives TGF-β1-dependent thrombus fibrosis
ORIGINAL RESEARCH article Volume 16 - 2025 | https://doi.org/10.3389/fimmu.2025.1681485 Introduction Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a major global cause of morbidity and mortality (1).
Evolution in Epidemiology and Antimicrobial Resistance Patterns of Bacteria Among Dermatology Patients: A Retrospective Study in a Tertiary Dermatology Hospital in China (2018–2023)
Back to Journals » Infection and Drug Resistance » Volume 19 Authors Chen S , Li X, Tian J Received 9 November 2025 Accepted for publication 25 February 2026 Published 12 March 2026 Volume 2026:19 580159 DOI https://doi.org/10.2147/IDR.S580159 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Hazrat Bilal Shi Chen,1 Xinzheng Li,2 Jiyun Tian1 1Department of Microbiology Laboratory, Hangzhou Third People’s Hospital,...
International Nursing Review | ICN Health Policy Journal | Wiley Online Library
Conflicts of Interest All authors declare no conflicts of interest.
The Responses of Extracellular Enzyme Activities to Saline Conditions: A Data Synthesis
Supporting Information Filename Description ldr70247-sup-0001-TableS1-S4-FigureS1.docxWord 2007 document , 452.8 KB Table S1a: Statistical information of the original enzyme activities in saline soils. Table S1b: Statistical information of the enzyme activities in saline soils excluding outliers. Table S2: Differences between enzyme activities measured by spectrophotometric (X) and fluorometric (Y) methods.
A Variational Theorem-Based Uncertain Initialization SOC Estimation Technique in Li-Ion Battery Applications
1. Introduction Click to copy section linkSection link copied! With the carbon neutrality goal reached in the middle of the 21st century, the serious environmental problems caused by the inevitable depletion of fossil fuels and carbon dioxide emissions compel humans to give up using fossil fuels as the main global energy source.
Frontiers | Case Report: A case of severe viral pneumonia complicated by pulmonary embolism treated with extracorporeal membrane oxygenation combined with interventional thrombectomy
Introduction H1N1 influenza is a well-established cause of severe viral pneumonia and acute respiratory distress syndrome (ARDS) (1). Its association with intermediate- to high-risk PE has been less frequently documented in the literature. The significant overlap in clinical manifestations often results in the under-recognition of PE in these patients, potentially delaying life-saving interventions.
Randomized, double‐blind phase III trial of a dexamethasone‐free regimen for managing highly emetogenic chemotherapy‐induced nausea and vomiting
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description ijc70069-sup-0001-Supinfo.pdfPDF document, 465.8 KB Data S1. Supporting Information. REFERENCES 1, , . Chemotherapy-induced nausea and vomiting: time for more emphasis on nausea? Oncologist. 2015; 20: 576-583. 2, , , , . Delayed nausea and vomiting continue to reduce patients' quality of life after highly and moderately emetogenic chemotherapy despite antiemetic treatment.
Flexibility meets rigidity: a self-assembled monolayer materials strategy for perovskite solar cells - Nature Communications
Abstract Self-assembled monolayer (SAM) materials have emerged as promising materials for interface engineering in perovskite solar cells. However, achieving an optimal balance between molecular packing density, charge transport efficiency, and defect passivation remains a challenge. In this work, we propose a SAM material design strategy that synergizes flexible head groups with rigid linking groups.
Deep learning-based prediction of mine water inflow: insights for mitigating water resource scarcity risks
Predicting mine water inflow is a complex challenge where traditional models often fail to accurately capture intricate temporal patterns. In this study, we introduce the Self-Attention mechanism into the prediction model. This model effectively captures long-term dependencies in time series, leading to more accurate predictions, particularly at data change peaks.
Asymmetric interfacial Ru single-atom sites and nanoparticles for promoting hydrogen evolution reaction in a wide pH range
Asymmetric interfacial Ru single-atom sites and nanoparticles for promoting hydrogen evolution reaction in a wide pH range Herein, the achieved asymmetric interfacial Ru single-atom sites and nanoparticles in Ru1+NPs/NPC through the coordination-pyrolysis strategy exhibits remarkable HER activities with small ovepotential and low Tafel slope in a wide pH range. You have access to this article This article has not yet been cited.
A Nd@C82-polymer interface for efficient and stable perovskite solar cells - Nature
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Abstract A critical challenge in the commercialization of perovskite solar cells (PSCs) is the simultaneous attainment of high power conversion efficiency (PCE) and high stability. Employing polymers interfaces in PSCs can enhance durability by blocking water and oxygen, and by suppressing ions interdiffusion, but their electronic shielding poses a challenge for efficient and stable PSCs1–3.
By Yuexin Rachel Lin, Zhichao Lin, Zuhong Zhang, Wenhan Yang, Jinbo Zhao, Hao Gu, Nan Zhang Verified, Shi Chen, Wei Ma, Guojia Fang, Guichuan Xing, Shengchun Yang, Tao Yang, Wenting Cai, Wei Huang, Annan Zhu
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