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Articles by Simon Keely
A microbiome meta-transcriptomics pipeline identifies a neutrophil elastase inhibitor that protects the colonic epithelial barrier
Abstract Inflammatory Bowel Diseases (IBD) are lifelong conditions. Current therapeutic approaches target inflammatory signalling rather than improving barrier permeability or repair. The gut microbiome provides an exciting opportunity for novel drug discovery to leverage its role in healthy gut homeostasis. There is a clear need to identify bioactive molecules within the microbiota that could protect the intestinal barrier.
Functional dyspepsia and gastroparesis: are they distinct disorders, a spectrum of diseases or one disease?
Introduction Overlapping symptoms between gastrointestinal (GI) conditions complicate diagnosis, treatment and management. This is particularly challenging for clinicians when the management of conditions differs substantially.
Coeliac disease is a strong risk factor for Gastro-oesophageal reflux disease while a gluten free diet is protective: a systematic review and meta-analysis
Keywords Gastroesophageal reflux disease Coeliac disease Oesophagitis Gluten Gluten-free diet Evidence before this study A systematic search of databases (pubmed and embase) yielded no previous systematic reviews or meta-analyses on the association of Coeliac disease and gastro-esophageal reflux disease (GORD).
Hypoxia alters the effects of hypomethylating agents in acute myeloid leukaemia cells.
Abstract Background Acute myeloid leukaemia (AML) is a deadly haematological malignancy that originates from mutated myeloid progenitor cells that lie quiescent in the hypoxic bone marrow. Elderly patients who cannot tolerate standard chemotherapies are administered low-dose hypomethylating agents (HMA) which act in a replication-dependent manner to reprogram the epigenome. Relapse is common following HMA treatment and may arise from quiescent leukaemia cells in the hypoxic bone marrow.
Beyond Eosinophilic Esophagitis: Eosinophils in Gastrointestinal Disease-New Insights, “New” Diseases
Disorders of gut–brain interactions (DGBIs) are highly prevalent, unexplained conditions that can markedly impact on quality of life.
Beyond Eosinophilic Esophagitis: Eosinophils in Gastrointestinal Disease-New Insights, “New” Diseases
Disorders of gut–brain interactions (DGBIs) are highly prevalent, unexplained conditions that can markedly impact on quality of life.
Enteric nervous system and intestinal epithelial regulation of the gut-brain axis
Black C.J. Drossman D.A. Talley N.J. Ruddy J. Ford A.C. Functional gastrointestinal disorders: advances in understanding and management. Lancet. 2020; 396: 1664-1674 Jones M.P. Tack J. Van Oudenhove L. Walker M.M. Holtmann G. Koloski N.A. et al. Mood and anxiety disorders precede development of functional gastrointestinal disorders in patients but not in the population. Clin Gastroenterol Hepatol. 2017; 15: 1014-1020.e4 Jones R. Latinovic R. Charlton J. Gulliford M.
Sleep disturbances in the irritable bowel syndrome and functional dyspepsia are independent of psychological distress: a population‐based study of 1322 Australians
ORIGINAL SCIENTIFIC PAPER Natasha A.
Mechanisms of Food-Induced Symptom Induction and Dietary Management in Functional Dyspepsia
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
What’s in a name? ‘Non-coeliac gluten or wheat sensitivity’: controversies and mechanisms related to wheat and gluten causing gastrointestinal symptoms or disease
The global population has more than doubled over the past 40 years, supported by the ‘green revolution’ in agriculture producing high-yield grain varieties, including wheat, that are central to the modern diet.1 Wheat covers more than 200 million hectares of land,2 is the third most produced cereal behind rice and maize,3 and is responsible for one-fifth of the world’s calorific input.2 Wheat contains gluten proteins, predominantly made of equal parts of glutenins and gliadins, which are...
What’s in a name? ‘Non-coeliac gluten or wheat sensitivity’: controversies and mechanisms related to wheat and gluten causing gastrointestinal symptoms or disease
The global population has more than doubled over the past 40 years, supported by the ‘green revolution’ in agriculture producing high-yield grain varieties, including wheat, that are central to the modern diet.1 Wheat covers more than 200 million hectares of land,2 is the third most produced cereal behind rice and maize,3 and is responsible for one-fifth of the world’s calorific input.2 Wheat contains gluten proteins, predominantly made of equal parts of glutenins and gliadins, which are...
The Bile Acids, Deoxycholic Acid and Ursodeoxycholic Acid, Regulate Colonic Epithelial Wound Healing
The intestinal epithelium constitutes an innate barrier which, upon injury, undergoes self-repair processes known as restitution. Although, bile acids are known as important regulators of epithelial function in health and disease, their effects on wound healing processes are not yet clear. Here we set out to investigate the effects of the colonic bile acids, deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) on epithelial restitution.
Towards an Integrated Understanding of the Therapeutic Utility of Exclusive Enteral Nutrition in the Treatment of Crohn’s Disease
Crohn’s disease (CD) is a chronic disease characterized by episodic and disabling inflammation of the gastrointestinal tract in genetically susceptible individuals. The incidence and prevalence of CD is rising rapidly across the world emphasising that disease risk is also influenced by environmental and lifestyle factors, as well as the microbial community resident in the gut.
Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
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