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Simone Mosole

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Articles by Simone Mosole

Commensal Nakaseomyces glabratus migrates into prostate tumors to accelerate cancer progression

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By Ping Lai, Lei Liu, Nicolò Pernigoni, Daniele Braga, Martina Troiani, Giuseppe Attanasio, Yuxin Li, Pan Song, Emiliano Pasquini, Tanja Rezzonico Jost, Xiaowen Huang, Martino Maddalena, Simone Mosole, Andrea Rinaldi, Giovanna Pecoraro, Martino Pedrani, Aurora Valdata, Nicolò Bancaro, Alessandra De Giani, Wei Yuan, Lewis Gallagher, Khobe Chandran, Penny Flohr, Pasquale Rescigno, Giuseppe Reitano, Alessandro Morlacco, Fabrizio Dal Moro, Isabella Giacomini, Monica Montopoli, Matteo Brunelli, Ricardo Mestre, Raad Z Gharaibeh, Christian Jobin, Johann De Bono, Andrea Alimonti, Yingxi Du, Luisa Maraccani, Serena Pedron, Silke Gillessen Sommer
| Nature Verified
Abstract Recent studies demonstrate that the gut mycobiota plays a key role in several tumors. However, the contribution of commensal fungi to prostate cancer initiation and progression remains understudied. Here we find that Nakaseomyces glabratus is enriched in fecal, blood and tumor samples of patients with castration-resistant prostate cancer, correlating with patients’ poor overall survival. Oral administration of N.
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Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis

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By Jessica Guerra, Maria Serena Merli, Pedro Ventura, Daniele Cavalli, Francesca Molinari, Andrea Rinaldi, Simone Moro, Ivo Kwee, Diego Morone, Simone Mosole, David Jarrossay, Luca Simonelli, Luca Varani, Egle Radice, Marcus Thelen, Clelia Di Serio, Margaret A. Shipp, Ryan D. Morin, David Scott Verified, Milo Frattini, Jessica Barizzi, Luciano Cascione, Francesco Bertoni, Davide F. Robbiani, Davide Rossi, Greta Guarda, Berenice A. Fischer, Hanif J. Khameneh, Alessandro Zenobi, Jasmine Ciorciari, Irene Buzzago, Alessandra Pfister, Lara Mattei, Chiara Montanino, Eleonora Calabretta, Kostantyn Dreval, Federico Jauk
| Nature Verified
Abstract Regulatory factor X 7 (RFX7) nonsense mutations have been found in different human B cell malignancies. We therefore set out to study the role of RFX7 in B cell activation and lymphomagenesis. Here we show that RFX7 truncations cause loss-of-function and dominant-negative effects. Moreover, low RFX7 mRNA levels correlate with worse diffuse large B cell lymphoma prognosis.
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Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability

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By Mariantonietta D’Ambrosio, Matthew White, Efthymios S. Gavriil, Laura Bousset, Jodie Birch, Aleksandra Gruevska, Emiliano Pasquini, Manuel Colucci, Winnie Fong, Simone Mosole, Aurora Valdata, Dimitris Veroutis, Katie Tyson, Vikas Ranvir, Joaquim Pombo, Sanjay Khadayate, George Young, àlex Montoya, Georgia Roumelioti, Jack Houghton Verified, Jianan Lu, Pavel V. Shliaha, Elena De Vita, Santiago Vernia, Vassilis G. Gorgoulis, Suchira Gallage, Mathias Heikenwalder, Zoe Dare Hall, Andrea Alimonti, Iain A. McNeish, Edward Tate, Jesús Gil, Sandra Prokosch, Aoki Ardisson
| Nature Verified
Abstract Senescent cells drive ageing and age-related pathologies, including cancer. Consequently, senolytics, drugs that selectively kill senescent cells, have broad therapeutic appeal. Here we report a senolytic screen of a library of 10,480 electrophilic compounds. Among 38 identified hits, we found a subset of chloroacetamides with broad senolytic activity. Activity-based protein profiling, coupled with functional assays, identified the glutathione peroxidase GPX4 as a target.
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Integrated control of cancer stemness by σ1 receptor in advanced prostate cancer - Oncogene

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By Gianluca Civenni, Giada Sandrini, Simone Mosole, Dheeraj A. Shinde, Matteo Pecoraro, Andrea Rinaldi, Marco Bolis, Roger L. Geiger, Sabrina Pricl, Giuseppina M. Carbone, Bernhard Wünsch, Carola Musumeci, Elisa Federici, Arianna Vallegra, Elisa Sorrenti, Riccardo Valzelli, Domenico Albino
| Nature Verified
Abstract Cancer stem cells (CSCs) are pervasively present in human cancers and have a fundamental role in treatment failure and disease recurrence. Identifying critical elements that sustain the CSC phenotype may lead to novel strategies for cancer treatment.
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An integrated proteomic portrait of prostate cancer progression

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By Jichang Zhang, Keith Rivera, Daniela Bossi, Federico Gianfanti, Simone Nicastri, Diana Gomes, Milos Matkovic, Marco Coazzoli, Simone Mosole, Federico Costanzo, Arianna Vallerga, Valentina Ceserani, Manuela Cavalli, Maya Virshup, Rajan Burt, Marco Bolis, Dorothea Ruthishauser, Anastasios Stathis, Holger Moch, Lukas Bubendorf, Andrea Cavalli, Eva Corey, Yuzhuo Wang, D.R. Mani, Steven Carr, Namrata D. Udeshi, Jean-Philippe Theurillat
| Cell Reports Verified
Keywords prostate cancer disease progression resistance to androgen receptor inhibition lineage plasticity protein phosphorylation ubiquitylation acetylation castration-resistant prostate cancer MAPK pathway Research topic(s) CP: Cancer Introduction Cancer follows a common disease trajectory in which transformed normal cells start to proliferate, form a local tumor, and metastasize to other organs.1 The latter is typically associated with fatal outcomes.
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