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Simon Wilkinson

Adelaide
As seen in: Color Research & Application, Wiley, NBC News, News.com.au, Archives of Disease in Childhood, Euronews, MDPI, Sydney Morning Herald, TODAY, The Daily Telegraph and
Food, restaurants and travel. Writing for The Advertiser in South Aus and beyond.

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Articles

ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology

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By Natalia Jiménez-Moreno, Katie Winnington-Ingram, Jimi Wills, Chinmayi Pednekar, Melina Overhoff, Katherine M Paine, Matthew Pearson, Lukas Gerasimavicius, Ann Wheeler, Natalia L. Kononenko, Joseph A. Marsh, Paul Verkade, Alex von Kriegsheim, Jon Lane, Simon Wilkinson, Arianna Karageorgiou
| Cell Press Verified
Keywords cytoskeleton cancer ER-phagy autophagy liquid-like condensate LLPS cAMP RHO GTPase lysosome cell invasion Introduction The endoplasmic reticulum (ER) is an extensive endomembrane network.1 While functioning in biosynthesis and calcium storage, the ER also provides a cellular organizing scaffold. Interorganellar contacts with the ER control mitochondrial, lysosomal, peroxisomal, and endosomal behavior.1 However, knowledge of cytoplasmic roles of ER remains incomplete.
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Use it or lose it: A ubiquitin-mediated autophagy pathway for degradation of MHC-I in pancreatic cancer

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By Simon Wilkinson
| Cell Press Verified
Get full text access Log in, subscribe or purchase for full access. References 1. Berquez, M. ∙ Li, A.L. ∙ Luy, M.A. ... A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer Mol. Cell. 2026; 86 2. Yamamoto, K. ∙ Venida, A. ∙ Yano, J. ... Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I Nature. 2020; 581:100-105 3. Dersh, D. ∙ Hollý, J.
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By Simon Wilkinson
| thecrag.com
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