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Sizun Jiang on Muck Rack

Sizun Jiang

Oakland, Vancouver
As seen in: Nature, Flipboard, BioRxiv, Cell Press, Cell Reports Medicine, The Journal of Biological Chemistry
Mac administrator, Network Analyst II
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Articles

Spatial transcriptomics identifies immune-stromal niches associated with cancer in adult dermatomyositis

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By Ksenia S. Anufrieva, Neda Shahriari, Ce Gao, Shideh Kazerounian, Rochelle Castillo, Jessica Liu, Sean A. Prell, Kartik Bhamidipati, Khashayar Afshari, Lindsay K. Parmelee, Anastasia Kazakova, Erin M Theisen, Teresa Bowman, Avery LaChance, William J. Crisler, Kimberly B. Hashemi, Ilya Korsunsky, Sizun Jiang, Mehdi Rashighi, Ruth Ann Vleugels, Kevin Choi Wei
| Nature Verified
Abstract Adult-onset dermatomyositis (DM) is an autoimmune inflammatory myopathy with distinct cutaneous manifestations and a strong association with malignancy. Through comparative analysis with cutaneous lupus erythematosus (CLE), our integrated spatial and single-cell transcriptomics analysis reveals unique immune and stromal niches associated with DM subtypes.
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Epstein-Barr virus orchestrates spatial reorganization and immunomodulation in the classic Hodgkin lymphoma tumor microenvironment

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By Yao Yu Yeo, Huaying Qiu, Yunhao Bai, Bokai Zhu, Yuzhou Chang, Fabio Iannelli, Jason Yeung, Hendrik A Michel, Yuchen Wang, Yang Wang, Wenrui Wu, Kyle Wright, Muhammad Shaban, Sam Sadigh, Dingani Nkosi, Vignesh Shanmugam, Philip Rock, Julia Paczkowska, Pierre Stéphan, Guanrui Liao, Amy Huang, Hongbo Wang, Han Chen, Leonie Frauenfeld, Louisa Kaufmann, Stefano A Pileri, Bidisha Mitra Verified, Benjamin E. Gewurz, Bo Zhao, Garry P. Nolan, Baochun Zhang, Alex K. Shalek, Michael Angelo, Christian M. Schürch, Faisal Mahmood, Roberto Chiarle, Qin Ma, W. Richard Burack, Margaret A. Shipp, Scott J. Rodig, Sizun Jiang, Precious Cramer
| Cell Reports Medicine Verified
Keywords multiplexed imaging spatial proteomics spatial transcriptomics EBV tumor virus tumor microenvironment Hodgkin lymphoma systems immunology Introduction Classic Hodgkin lymphoma (cHL) is a B cell lymphoid malignancy that most frequently occurs in young adults and less commonly in the elderly.1 The cHL tumor microenvironment (TME) has unique features, including rare malignant Hodgkin and Reed-Sternberg (HRS) multinucleated cells (comprising 1%–5% of the cHL TME cell composition) nested...
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Counteracting FOX proteins epigenetically control the herpesvirus lytic-latent balance - Nature Communications

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By Hyung Suk Oh, Zeyu Sun, Biswajit das, Yao Yu Yeo, Sizun Jiang, David Knipe, Donald M. Coen
| Nature Verified
Abstract The lytic-latent balance is a major viral persistence strategy and obstacle to curing viral diseases, yet its mechanisms remain poorly understood. Following lytic infection in non-neuronal cells, herpes simplex virus (HSV) establishes latency specifically in neurons and is reactivated by stresses.
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