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Articles by Son Le
Air pollution and rice crop health: evidence from Vietnam’s Mekong Delta
Abstract Ambient air pollution is a growing concern in Southeast Asia, yet its effects on crop performance remain less understood than its effects on human health. Here, we examine whether fine particulate matter (PM2.5) exposure is associated with rice crop health in Vietnam’s Mekong Delta, a major global rice-producing region.
Direction-resolved nanoscale optical imaging with near-nanometer resolution by emerging infrared torsional force microscopy
Abstract Resolving nanoscale light-matter interactions requires both high spatial resolution and anisotropic sensitivity to in-plane and out-of-plane optical responses. We introduce torsional force microscopy-infrared microscopy, a new optical imaging technique that combines cantilever torsional dynamics with a nonlinear frequency-mixing scheme to map both in-plane and out-of-plane photothermal signals.
Reusable Agents Meet Generative UIs: Announcing Open Agent Specification support for A2UI through CopilotKit AG-UI
Agent frameworks have become great at reasoning, orchestration, and tool execution. But the moment you want to ship a real product experience, such as interactive UI, mid-run progress, state that stays in sync, you often end up rebuilding the same “middle layer” in every stack.
Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial - Nature Communications
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Abstract Immune checkpoint inhibitors (ICIs) show minimal efficacy in recurrent high-grade astrocytoma (rHGA). Laser interstitial thermal therapy (LITT), a minimally invasive cytoreductive approach, may prime rHGA for ICI response. A phase 1/randomized phase 2b trial (ClinicalTrials.gov: NCT02311582) was designed to test pembrolizumab in combination with LITT in patients with rHGA. Nine patients were enrolled in the phase I dose-escalation lead-in study.
By Jian L. Campian, Son Le, Sơn Lê, Ashley Ghiaseddin, Omar Butt, Dongjiang Chen, Yifei Xu, Jingxia Liu, Maryam Rahman, William A. Leidig, George Ansstas, Alice Zhou, Sangami Pugazenthi, Gavin P. Dunn, Jiayi Huang, Milan G. Chheda, Albert Kim, Eric C. Leuthardt, David Tran, David Trần, Harshit Manektalia, Nathan Thai, Tanner Johanns
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Nature
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Understanding Human-Computer Interaction with Shared Autonomous Shuttles through Twin Experience: A Hybrid Choice Modeling Approach
?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. Abstract This study investigates future mobility with the introduction of shared autonomous shuttles (SASs), focusing on how human–computer interaction (HCI) influences travel decisions, using a twin experience survey approach.
The System Isn’t Broken. It Was Built This Way.
The System Isn’t Broken. It Was Built This Way. It’s Time We Built One That Works for Us. Why is it easier to buy a latte than get a doctor’s appointment? Why can you order a couch from your phone, but not vote for a park in your neighborhood? Why are we told we live in a democracy—yet have no say in the things that shape our everyday lives? The truth is, our economy wasn’t designed for us.
Filling the Holes on 3D Heritage Object Surface Based on Automatic Segmentation Algorithm
Conflicts of Interest The authors declare no conflicts of interest. References 2013. “Computer Graphics and Geometric Modelling—A Hybrid Approach.” International Journal of Pure and Applied Mathematics 85, no. 4: 781–811. , and . 2021. Laser Point Cloud Segmentation in MATLAB, 1–20. London, UK: IntechOpen. 2013. “Efficient Computation of Bezier Curves From Their Bernstein-Fourier Representation.” Journal of Applied Mathematics and Computation 220: 235–238. , , , and . 2023.
[2409.05532] Revisiting Accurate Geometry for Morse-Smale Complexes
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Exploratory Educational Initiatives Enhancing Primary School Teachers' Ability to Guide and Assist Students in Learning Activities
DOI: https://doi.org/10.24857/rgsa.v18n9-102 Keywords: Primary School Teachers, Student Support, Educational Activities, Pedagogical Experiments Download data is not yet available. References Alsadi, M. M., Momani, K. S. A., Daradkah, A. M., Alomari, M. A., & Awais, B. E. (2024). The Impact of E-Learning on Learnlng Out Comes at the Jordanian Universities.
Modelling and Multi-Objective Optimisation of Finger Joints: Improving Flexural Performance and Minimising Wood Waste
Abstract : The wood industry faces the dual requirements of improving the quality of timber products and minimising waste during the manufacturing process. The finger joint, which is an end-to-end joining method for timber boards, is one of the most important aspects of engineering wood products. This study presents a numerical and optimisation investigation of the effects of finger-joint design parameters on the flexural behaviour of finger-jointed timber beams.
Chine-Des écoles ferment à Pékin face au regain de contaminations au COVID-19
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DEEP C Industrial Zones set up for sustainable future
After 25 years of constant development, the DEEP C Industrial Zones cluster has proved to be one of the most successful models of its kind in the country. After 25 years of constant development, the DEEP C Industrial Zones cluster has proved to be one of the most successful models of its kind in the country, contributing to the socioeconomic development of the northern city of Haiphong and playing a compelling role in the Hanoi-Haiphong-Quang Ninh economic triangle in northern Vietnam.
High-Throughput Screening and Literature Data Driven Machine Learning Assisting Investigation of Multi-component La2O3-based Catalysts for Oxidative Coupling of Methane
High-Throughput Screening and Literature Data Driven Machine Learning Assisting Investigation of Multi-component La2O3-based Catalysts for Oxidative Coupling of Methane Multi-component La2O3-based catalysts for oxidative coupling of methane (OCM) were designed based on high-throughput screening (HTS) and literature datasets with multi-output machine learning (ML) approaches including random forest regression (RFR), support vector regression (SVR), Gaussian process regression (Bayesian), and...
Selective hydrogenation of succinic acid to gamma-butyrolactone with PVP-capped CuPd catalysts
Selective hydrogenation of succinic acid to gamma-butyrolactone with PVP-capped CuPd catalysts† Selective hydrogenation of succinic acid (SA) is not an easy task especially toward γ-butyrolactone (GBL) which readily undergoes further hydrogenation. Herein, poly(N-vinyl-2-pyrrolidone)-capped CuPd catalysts have been studied for the production of highly selective GBL from SA.
Selective hydrogenation of succinic acid to gamma-butyrolactone with PVP-capped CuPd catal
Selective hydrogenation of succinic acid to gamma-butyrolactone with PVP-capped CuPd catal Selective hydrogenation of succinic acid (SA) is not an easy task especially toward γ-butyrolactone (GBL) which readily undergoes further hydrogenation. Herein, poly(N-vinyl-2-pyrrolidone)-capped CuPd catalysts have been studied for the production of highly selective GBL from SA.
An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation
Highlights • TMEM16A possesses a third high-affinity Ca2+ binding site between TM2 and TM10 • Binding of Ca2+ to the third Ca2+ site allosterically promotes channel opening • Neutralizing coordinating residues abolishes Ca2+ binding to the third site • An engineered Cd2+ metal bridge at the third Ca2+ site inhibits channel activation Summary Calcium (Ca2+) is the primary stimulus for transmembrane protein 16 (TMEM16) Ca2+-activated chloride channels and phospholipid scramblases, which...
Evidence that polyphenols do not inhibit the phospholipid scramblase TMEM16F
Trieu Le1, Son C. Le1, Yang Zhang1, Pengfei Liang1 and Huanghe Yang1,2* 1Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, USA 2Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA ↵*For correspondence: Huanghe Yang, huanghe.yang{at}duke.edu.
Evidence that polyphenols do not inhibit the phospholipid scramblase TMEM16F
Abstract TMEM16 Ca2+-activated phospholipid scramblases (CaPLSases) mediate rapid trans-membrane phospholipid flip-flop and as such play essential roles in various physiological and pathological processes such as blood coagulation, skeletal development, viral infection, cell-cell fusion and ataxia. Pharmacological tools specifically targeting TMEM16 CaPLSases are urgently needed to understand these novel membrane transporters and their contributions to health and disease.
Rapid, Quantitative Therapeutic Screening for Alzheimer’s Enzymes Enabled by Optimal Signal Transduction with Transistors
Rapid, Quantitative Therapeutic Screening for Alzheimer’s Enzymes Enabled by Optimal Signal Transduction with Transistors We show that simple, commercially sourced n-channel silicon field-effect transistors (nFETs) operating under closed loop feedback to maintain a constant channel current exhibit an ~3-fold improvement in pH readout resolution to (7.2+/10.3)x10^-3 at a bandwidth of 10 Hz when compared with the open loop operation commonly employed by integrated ion-sensitive field-effect...
An inner activation gate controls TMEM16F phospholipid scrambling
Abstract Transmembrane protein 16F (TMEM16F) is an enigmatic Ca2+-activated phospholipid scramblase (CaPLSase) that passively transports phospholipids down their chemical gradients and mediates blood coagulation, bone development and viral infection. Despite recent advances in the structure and function understanding of TMEM16 proteins, how mammalian TMEM16 CaPLSases open and close, or gate their phospholipid permeation pathways remains unclear.
Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids
Trieu Le‡1, Son C. Le‡1 and Huanghe Yang‡,§2 From the Departments of ‡Biochemistry and §Neurobiology, Duke University Medical Center, Durham, North Carolina 27710 ↵2 To whom correspondence should be addressed: Box 3711, DUMC, Durham, NC 27710. Tel.: 919-684-1406; Fax: 919-684-8885; E-mail: huanghe.yang{at}duke.edu. ↵1 These authors contribute equally to this work.
Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel
Cool mechanism for sensing cool In humans, cold is primarily sensed by transient receptor potential melastatin member 8 (TRPM8), a calcium channel. Yin et al. present cryo–electron microscopy structures of TRPM8 with cooling agents, membrane lipid phosphatidylinositol-4,5-bisphosphate (PIP2), and calcium. Structural and functional analyses showed that the PIP2 binding site in TRPM8 is completely different from PIP2 sites in other TRP channels.
Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel
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Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids
Trieu Le1, Son C Le1 and Huanghe Yang2* 1Duke University School of Medicine, United States 2Biochemistry, Duke University School of Medicine, United States ↵* Corresponding author; email: huanghe.yang{at}duke.edu Author contributions: T.L. and S.C.L. formal analysis; T.L. and S.C.L. investigation; T.L., S.C.L., and H.Y. methodology; T.L., S.C.L., and H.Y. writing-original draft; H.Y. conceptualization; H.Y. resources; H.Y. supervision; H.Y. funding acquisition; H.Y. project administration.
Conformational plasticity in the selectivity filter of the TRPV2 ion channel
a,b, Representative whole-cell recordings from HEK293T cells expressing TRPV2 (n = 14), miTRPV2 (n = 9) and miTRPV2 (n = 3) in response to RTx (repeated voltage ramps from −60 mV to +60 mV at 5 s intervals). The blue bar indicates application of 50 nM RTx, and the red bar 200 μM ruthenium red. a stands for basal currents, b for stationary RTx-evoked currents, and c for RuR-inhibited currents.
Hướng dẫn cách bảo quản hành tăm dùng quanh năm
Hành t?m có tên g?i khác là c? nén là ??c s?n c?a vùng x? Ngh?. Nó ???c dùng nh? c? hành khô ngoài b?c nh?ng b? th?m h?n nên s? t?o nên h??ng v? r?t riêng cho các món nh?: Cháo l??n, Cháo ngao, trai, canh gà, cá ??ng… Sau ?ây mình xin chia s? cách b?o qu?n c? nén( hành t?m) ??n gi?n tai nhà mà b?t c? ai c?ng có th? làm ???c ?? ?n trong 1 vài tháng các b?n có th? chia vào các túi nh? ho?c cho vào h?p nh?a có n?p ??y l?i và tr? trong ng?n mát t? l?nh. M?t thêm chút th?i gian các b?n có th? b?c hành vào trong các t?
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