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Abstract Cancer cells show highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour1,2,3,4,5. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here we generated a deep single-cell and spatial multi-omic atlas of human glioblastoma that pairs transcriptomic, epigenomic and genomic profiling of 12 tumours across many regions.
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Communication Clemens Kaminski Corresponding Author E-mail address: cfk23@cam.ac.uk UNITED KINGDOM Search for more papers by this author Abstract We report the use of DNA origami nanostructures, functionalized with aptamers, as a vehicle for delivering the antibacterial peptide lysozyme in a specific and efficient manner. We test the system against Gram positive ( Bacillus subtilis ) and Gram negative ( Escherichia coli ) targets.
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