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Articles by Steven Hebert
Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
Abstract Posterior fossa type A (PFA) ependymoma is an unusual infantile brain tumour with few known somatic mutations, thought to be driven by epigenetic mechanisms1. PFA ependymoma has a markedly higher incidence and worse prognosis in male children than in female children2. The mechanisms that underlie these sex differences are at present unknown. Here we show that the cellular hierarchy of PFA ependymoma is less differentiated in male individuals than it is in female individuals.
Author Correction: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas - Nature Communications
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Correction to: Nature Communications https://doi.org/10.1038/s41467-025-61820-z, published online 31 July 2025 In the version of the article initially published, there were errors in the ninth paragraph of the Results, where in the text now reading “Within the DFCI and KiTZ cohorts, in which all tumors underwent review by a pediatric neuropathologist, 85% (17/20) of all FGFR1 rearrangements and/or ITDs occurred in the context of pLGGs, versus 15% (3/20) in the pHGGs,” 85% (17/20) was...
By April Apfelbaum, Dominik Sturm, Georges Ayoub, Bhavyaa Chandarana, Dana Novikov, Tania Jones, Jared Collins, Kelly Cai, Hyesung Jeon, Jinhua Wang, Patrick Rechter, Karthikeyan Murugesan, Meagan Montesion, Lee A. Albacker, Philipp Sievers, Felix Sahm, Kee Kiat Yeo, Tom Rosenberg, Susan N. Chi, Steven Hebert, Alberto Picca, Valérie Larouche, Sara J. Buhrlage, Mehdi Touat, Nada Jabado, Eric S. Fischer, Olaf Witt, Claudia L. Kleinman, Denise Sheer, Keith L. Ligon
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Nature
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A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas - Nature Communications
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Abstract Oncogenic alterations in fibroblast growth factor receptor (FGFR)-family proteins occur across cancers, including pediatric gliomas. Our genomic analysis of 11,635 gliomas across ages finds that 5.3% of all gliomas harbor FGFR alterations, with an incidence of almost 9% in pediatric gliomas. Alterations in FGFR proteins are differentially enriched by age, tumor grade, and histology, with FGFR1 alterations associated with glioneuronal histologies.
By April Apfelbaum, Dominik Sturm, Georges Ayoub, Bhavyaa Chandarana, Tania Jones, Jared Collins, Kelly Cai, Hyesung Jeon, Jinhua Wang, Karthikeyan Murugesan, Meagan Montesion, Lee A. Albacker, Philipp Sievers, Felix Sahm, Kee Kiat Yeo, Tom Rosenberg, Susan N. Chi, Steven Hebert, Alberto Picca, Valérie Larouche, Sara J. Buhrlage, Mehdi Touat, Nada Jabado, Eric S. Fischer, Olaf Witt, Claudia L. Kleinman, Keith L. Ligon, Dana Novikov, Patrick Rechter, Denise Sheer
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Nature
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Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function - Nature Communications
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Abstract Histone H3-mutant gliomas are deadly brain tumors characterized by a dysregulated epigenome and stalled differentiation. In contrast to the extensive datasets available on tumor cells, limited information exists on their tumor microenvironment (TME), particularly the immune infiltrate. Here, we characterize the immune TME of H3.3K27M and G34R/V-mutant gliomas, and multiple H3.3K27M mouse models, using transcriptomic, proteomic and spatial single-cell approaches.
By Augusto Faria Andrade, Alva Annett, Yitong Liu, Selin Jessa, Geoffroy Danieau, Steven Hebert, Valérie Larouche, Daniela F. Quail, Liza Konnikova, Logan A. Walsh, Manav Pathania, Claudia L. Kleinman, Danai Georgia Topouza, Arne Gehlhaar, Antonella De Cola, Bhavyaa Chandarana, Evan Puligandla, Nikoleta Juretic
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Nature
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Diagnostic Utility of Interleukin-6 in Early-Onset Sepsis among Term Newborns: Impact of Maternal Risk Factors and CRP Evaluation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Children | Free Full-Text | “Multisystem Inflammatory Syndrome in Children”-Like Disease after COVID-19 Vaccination (MIS-V) with Potential Significance of Functional Active Autoantibodies Targeting G-Protein-Coupled Receptors (GPCR-fAAb) for P
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Children | Free Full-Text | “Multisystem Inflammatory Syndrome in Children” (MIS-C) after COVID-19 Infection in the Metropolitan Area of Nuremberg-Erlangen, Germany-Expectations and Results of a Two-Year Period
Open AccessArticle by 1,*, 1, 2, 2, 2, 3, 3, 4, 4, 1, 1, 1, 1, 1, 1, 5 and 1 1 Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, 91054 Erlangen, Germany 2 Hospital for Children and Adolescents Furth, 90766 Furth, Germany 3 Pediatrics—Children’s Department Nuremberg Hospital South, 90471 Nuremberg, Germany 4 Cnopf Children’s Hospital, Diakoneo Klinikum Hallerwiese Nuremberg, 90419 Nuremberg, Germany 5 Department of Ophthalmology, University Hospital Erlangen,...
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas - Nature Genetics
Abstract Canonical (H3.1/H3.2) and noncanonical (H3.3) histone 3 K27M-mutant gliomas have unique spatiotemporal distributions, partner alterations and molecular profiles. The contribution of the cell of origin to these differences has been challenging to uncouple from the oncogenic reprogramming induced by the mutation.
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
Highlights • 50% of H3.3 G34R/V high-grade gliomas carry activating PDGFRA mutations • G34R/V gliomas originate in GSX2-expressing interneuron progenitors • PDGFRA co-opts GSX2 enhancer elements for aberrant expression • Mutant PDGFRA promotes astrogenesis and is a potent oncogenic driver, unlike G34R/V Summary Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive...
PRMT5 is essential for B cell development and germinal center dynamics
Abstract Mechanisms regulating B cell development, activation, education in the germinal center (GC) and differentiation, underpin the humoral immune response. Protein arginine methyltransferase 5 (Prmt5), which catalyzes most symmetric dimethyl arginine protein modifications, is overexpressed in B cell lymphomas but its function in normal B cells is poorly defined.
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