Sumit Rai
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Articles by Sumit Rai
Sensitivity to ATR–CHK1 pathway inhibition in MDS/AML is enhanced by SRSF2 mutations and reduced by RUNX1 loss
Abstract SRSF2 mutations occur in 5–15% of acute myeloid leukemia (AML) and ~15% of myelodysplastic neoplasms (MDS), are enriched in elderly/secondary AML, and lack mutation-directed therapy. We aimed to identify vulnerabilities in MDS/AML with SRSF2 mutations. Ex vivo drug-sensitivity testing of bone marrow cells from AML patients and controls showed that SRSF2-mutant cells are sensitive to CHK1 and WEE1 inhibitors.
US California Lifeguard Child Rescue
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US California Lifeguard Child Rescue
The father of a 10-year-old rescued from pounding surf off the California coast in a dramatic scene captured on video says he is beyond grateful to the teenage lifeguard who saved his son. Sumit Rai's son Nathaniel was standing in shallow water when he was pulled into the ocean Saturday by powerful swells that suddenly came ashore at Seabright Beach in Santa Cruz. Rai said Wednesday he heard about what happened when he spoke to his kids and his son told him he'd drowned.
US California Lifeguard Child Rescue
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This undated photo taken and provided by Sumit Rai shows his son, Nathaniel, 10, who was the one rescued Saturday, July 25, 2026, in Santa Cruz by the teen lifeguard.
US California Lifeguard Child Rescue
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US California Lifeguard Child Rescue
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US California Lifeguard Child Rescue
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US California Lifeguard Child Rescue
The father of a 10-year-old rescued from pounding surf off the California coast in a dramati…
Mutant SRSF2-associated impaired erythropoiesis is defined by increased mTORC1 signaling due to FYN missplicing - Leukemia
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Abstract Somatic mutations in RNA splicing regulators, including the serine/arginine-rich protein SRSF2, are frequently observed in myeloid malignancies. Using mouse models and primary human samples, we investigated the impact of SRSF2 mutations on erythropoiesis. We found reduced erythropoiesis in Srsf2P95H versus wild-type mice upon stress-induced erythropoiesis and identified that SRSF2 mutations correlate with reduced hemoglobin in JAK2-mutant patients with myeloproliferative neoplasms (MPN).
By Jonas S. Jutzi, Edie I. Crosse, Chulwoo Kim, Charles Laurore, Benjamin Rolles, Frederike Kramer, Azucena Rocha, Mohammed Wazir, Lachelle D. Weeks, Joan How, Maximilian Stahl, Marlise R. Luskin, R. Coleman Lindsley, Olga Pozdnyakova, Sumit Rai, Timothy A Graubert, Robert Bradley, Ann Mullally, Anna E. Marneth, Bob van Gasteren, Anastasia Tishena
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Nature
Verified
Design Starts in the Mind: Why the First Shift Is Always Mental
Exploring how mindset shapes design, product psychology, and performance — in work and in life. Before a wireframe is drawn, a logo designed, or a product launched — something else must change: your mindset. In my journey through design, product, and storytelling, one truth has remained consistent: The biggest leaps — creative, strategic, personal — don’t begin with better tools. They begin with better thinking. Design is often seen as output. Visual. Tactical. Executional.
Webinar: Indian Insolvency And Bankruptcy - A Medley Of Rights
AA Agama Law Associates More ALA is a boutique commercial law practice offering end-to-end corporate-commercial legal solutions to Indian and foreign businesses. We offer a wide range of services tailored across sectors for private clients, startups and mature businesses. We have a cost-effective technology based model supported by a large network of associates. Commercial transactions and advisory is our forte, which includes contract management and standardization.
Indian Insolvency and Bankruptcy - A Medley of Rights
Is your business facing financial challenges? Are you a creditor unsure of your rights? This informative webinar unpacks the evolving world of Indian Insolvency and Bankruptcy Code (IBC). Join Agama Law Associates and a distinguished expert panel for a deep dive into critical topics: The IBC's Impact on Indian Markets: How is the IBC transforming the business landscape? A Balanced View: IBC's Implementation - Boon or Bane for Creditors and Debtors?
UPCOMING WEBINAR: Indian Insolvency And Bankruptcy - A Medley Of Rights
AA Agama Law Associates More ALA is a boutique commercial law practice offering end-to-end corporate-commercial legal solutions to Indian and foreign businesses. We offer a wide range of services tailored across sectors for private clients, startups and mature businesses. We have a cost-effective technology based model supported by a large network of associates. Commercial transactions and advisory is our forte, which includes contract management and standardization.
Indian Insolvency and Bankruptcy - A Medley of Rights
Please join Agama Law Associates and an esteemed panel for an informative session covering Indian Insolvency and Bankruptcy. Topics covered: How IBC is evolving the Indian Markets. IBC implementation till date, whether curse or boon creditors and debtors perspective. The expanding nature of IBC. Perspective of the operational creditor - is his cause a lost cause? The debtor - can he expect a new lease of life. The resolution professional and limits they operate in.
New Year 2024: Economic resilience, industry reforms keep insurance sector buoyant
Indian economy continued to show remarkable strength in 2023 amid an evident global slowdown. This strength was largely driven by robust consumption, strong investment activity, and a burgeoning, aspirational consumer class. The country’s focus in recent years on bringing progressive policy reforms, and digital transformation has also supported this growth trajectory, enabling India to outperform its peers globally, particularly those in the Asian Pacific region.
Nitish Kumar को पटना HC से बड़ी राहत, जारी रहेगी जातीय जनगणना; रोक की अर्जी खारिज
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टेक कंपनी के CEO ने ली कैब और फिर हो गया अचानक गायब, 18 महीने बाद हुआ खौफनाक खुलासा
Tech CEO Found Dead: एक टेक कंपनी के सीईओ ने करीब 18 महीने पहले उबर कैब ली और राइड के दौरान अचानक गायब हो गए. अब इस मामले में पुलिस ने बड़ा खुलासा किया और उसके अवशेष बरामद किए हैं. Written By Sumit Rai|Last Updated: May 10, 2023, 04:17 PM IST एक टेक कंपनी के सीईओ ने अपनी कंपनी के पास से ही उबर कैब ली और फिर राइड के दौरान ही अचानक गायब हो गए. बताया जा रहा है कि 18 महीने पहले वो उबर कैब से निकले थे और उसके बाद उनकी कोई जानकारी नहीं मिली.
इन 2 राजकुमारियों को देख दुनिया हुई दीवानी, सादगी ऐसी कि फोटो देख लोग हार बैठे दिल
नीदरलैंड्स के रॉटरडैम में किंग्स डे के मौके पर राजा विलियम एलेक्जेंडर की पत्नी और महारानी मैक्सिमा के अलावा राजकुमारी एरियन (Ariane) और राजकुमारी कैथरीना-अमलिया (Catharina-Amalia) समेत परिवार के अधिकांश लोग शामिल हुए. Written By Sumit Rai|Last Updated: Apr 27, 2023, 11:17 PM IST नीदरलैंड में गुरुवार को किंग विलियम एलेक्जेंडर (Willem-Alexander) का जन्मदिन मनाया गया. इस दौरान नीदरलैंड्स के रॉटरडैम में किंग्स डे का जश्न भी मनाया गया.
Tarek Fatah Dies: मशहूर लेखक तारेक फतेह का निधन, बेटी ने बताया- हिंदुस्तान का बेटा
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Career opportunity in air transport and logistics in India
The Indian aviation industry is expected to become the third-largest aviation market globally by 2025. By Sumit Rai The air transport and logistics industry in India has been growing exponentially in the last few years. With an increase in globalization and economic growth, industry has become an essential component of the country's infrastructure.
Food Crisis: भारत में खाने को लेकर आने वाला है गंभीर संकट! UN ने दी चेतावनी
Global Warming: संयुक्त राष्ट्र (UN) के विशेषज्ञों के एक पैनल ने चेतावनी देते हुए कहा है कि ग्लोबल वार्मिंग की वजह से भारत के खाद्य उत्पादन (Food Production) में भारी गिरावट आ सकती है. Written By Sumit Rai|Last Updated: Mar 21, 2023, 02:33 PM IST संयुक्त राष्ट्र (United Nation) ने भारत को लेकर चेतावनी दी है और कहा है कि अगर ग्लोबल वार्मिंग (Global Warming) पर काबू नहीं पाया गया तो देश में खाने को लेकर गंभीर संकट आ सकता है.
Russia-Ukraine War को लेकर आया बड़ा अपडेट, पुतिन ने कह दी ये बड़ी बात
Vladimir Putin-Xi Jinping Meeting: व्लादिमीर पुतिन ने क्रेमलिन में अपने चीनी राष्ट्रपति शी जिंगपिंग (Xi Jinping) के साथ मुलाकात के दौरान कहा कि रूस हर समय बातचीत के लिए तैयार है. Written By Sumit Rai|Last Updated: Mar 21, 2023, 02:05 PM IST रूस और यूक्रेन के बीच एक साल से ज्यादा हो गया है और रूसी सेना लगातार यूक्रेन के अलग-अलग शहरों पर हमला कर रही है.
Rahul Gandhi ने मिस्र के मुस्लिम ब्रदरहुड से की RSS की तुलना, भारत-चीन रिश्ते को बताया रूस-यूक्रेन युद्ध जैसा
Rahul Gandhi on China: राहुल गांधी (Rahul Gandhi) ने राष्ट्रीय स्वयं संघ (RSS) पर निशाना साधा और भारत-चीन रिश्ते (India China Relation) को लेकर भी अपनी बात रखी. इसके साथ ही राहुल गांधी ने भारतीय जनता पार्टी (BJP) पर भी प्रहार किया और कहा कि कि सत्तारूढ़ दल 'नफरत और हिंसा की विचारधारा' का अनुसरण कर रहा है.
Scholarships' Opportunities In Air Transport & Logistics In Germany
Germany has long been a popular destination for international students looking to further their education. With its strong economy, world-class universities and excellent standard of living, it's no surprise that students from all over the world come to Germany to pursue higher education. For those interested in air transport and logistics, there are many scholarship opportunities available in Germany.
Nepal के PM प्रचंड ने अचानक रद्द की कतर की यात्रा, जानें क्या है वजह
Pushpa Kamal Dahal Prachanda: नेपाल के प्रधानमंत्री पुष्प कमल दहल 'प्रचंड' की कतर यात्रा रद्द कर दी गई है. प्रचंड की सरकार पर मंडरा रहे खतरे और आगामी राष्ट्रपति चुनाव के बीच यह फैसला किया गया है. Written By Sumit Rai|Last Updated: Feb 27, 2023, 02:25 PM IST नेपाल के प्रधानमंत्री पुष्प कमल दहल 'प्रचंड' (Pushpa Kamal Dahal 'Prachanda') की कतर यात्रा रद्द कर दी गई है.
New era of customer centricity awaits as IRDAI lays the groundwork Original
In recent memory, 2022 is perhaps the most significant year as far as insurance regulatory reforms are concerned. Aligned with its vision of ‘Insurance for All by 2047’, the regulator has announced many progressive measures to facilitate wider access to insurance and strengthen customer experience. These changes will herald a new era of customer centricity and play a vital role in bringing the sector into the same orbit as its global peers.
New era of customer centricity awaits as IRDAI lays the groundwork
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Is year 2022 a pre-cursor to long-term insurance industry growth?
The Indian economy continued to show remarkable resilience amid challenging few years, driven by a triad of factors – progressive policy reforms, strong macroeconomic fundamentals, and an aggressive digital push. This display of economic strength has prompted financial pundits to estimate that India will become the 3rd largest economy by 2030. As India sprints towards this aspiration, the insurance sector will play a vital role in fueling its global ambitions.
How InsurTech is redefining insurance - ET BFSI
Over the past two decades, regulatory changes, emergence of technology, and evolving customer expectations have effected widespread changes in the insurance sector. More recently, catastrophes like cyclones and the pandemic have bolstered the need for effective financial risk management at the individual level. These moving variables have offered a fertile playground for budding Insurtech companies to leverage AI, Internet of Things (IoT), Predictive Analytics, etc.
ET-Insights
Digitization has proven to be a significant boon to the insurance industry; here's a quick rundown of how modern-day tech solutions have helped with fraud detection. A geographically diverse and complex country like India makes the business of insurance interesting. Its cultural multiplicity, disparity in standards of living, and the vast variance in opportunities across geographies offers layers of insights into how each customer perceives financial risks.
Govt’s focus on ‘Digital’ paves way for new India - ET BFSI
Sumit Rai, MD & CEO, Edelweiss Tokio Life Insurance Union Budget 2022 is an illustration of the government’s bifocal vision. It has proposed several growth-enabling measures for the near term and announced a blueprint for a future-ready India over the next 25 years. Emphasizing that digital will be fundamental to India’s Amrit Kaal, this Budget has showed a decisive focus on digital initiatives to put India at the center of the global technological revolution.
VEGAS Creative Software Team About Its Beliefs, Prices & Roadmap
Sumit Rai, Chief Product Officer for VEGAS Creative Software, told us about the company's goals, talked about VEGAS pricing policy, and shared the plans for the future. VEGAS Creative Software released VEGAS Pro 19 back in August, providing improved video and audio editing, color grading, effects, live streaming, and cloud-integrated content management and acquisition.
Career With Transportation Economics
Transportation Economics can open up various opportunities for students if they know where to look. India is undergoing rapid urbanization. This has created an influential impact on the way urban transportation evolves in the country. According to the estimates, the Indian economy is expected to grow by 12 per cent in 2021 following a 7.1 per cent contraction in 2020. This creates a huge demand for a robust transport infrastructure and services to promote urban mobility in the country.
Insurance in the time of the pandemic
Greater digital adoption has increased the risk of fraud. Without personal interactions, assessing the risk profile of customers has become an arduous task Topics Insurance | Life Insurance Sumit Rai Last Updated at May 23, 2021 22:10 IST https://mybs.in/2ZeRJ7l The life insurance business is at an inflection point. Recognising its need for financial protection in combatting future risks, people have a better understanding of the value of life insurance in the middle of a pandemic.
LIFE INSURANCE: Fund value of Ulip is amount invested plus returns earned
Ulip , Thinkstock Share Updated: Mar 5, 2019, 06:35 AM IST In a life insurance policy how is fund value different from sum assured? – Akash Gopalakrishnan Fund value is applicable to Unit Linked Insurance Plans. Under these plans, the premiums paid by a customer is invested as per their choice of funds. This invested amount along with the returns earned are referred to as fund value and is represented through number of units.
Information not declared while buying the policy could lead to claim denial
Life Insurance , Istock Share Updated: Feb 20, 2019, 06:35 AM IST I am working in the power sector. Will a life insurance plan cover nuclear risk? Do I have to state my profession while buying the policy? - Gireesh Kumar It is very important to reveal one's profession and related details at the time of purchasing a policy, as crucial information not declared at the onset of the policy could lead to denial of the claim.
LIFE INSURANCE: Premium will depend on how overweight/obese individual is
Insurance Share Updated: Feb 12, 2019, 06:35 AM IST I wanted to buy a money back plan. Since I am overweight the agent told me that my insurance premium may increase after the medical test. But I have no sugar or BP. So why should the premium increase? – Alok Panchal The premium would depend upon the how overweight/obese an individual is. However, if all the other health parameters are normal, favourable terms can be offered basis the underwriting norms of the company.
Postal life insurance currently offers only traditional policies
Is post office insurance different from life insurance? Is it a good idea to invest in post office insurance? – Ankita Roy Postal life Insurance extend their services only to government employees, defence personnel, etc. Furthermore, postal life insurance offers traditional plans currently. Since there are limited options available with postal life insurance you can also explore other life insurance options available in the market for larger spectrum of cover.
Submit earlier medical reports while buying new policy
Life Insurance , Thinkstock Share Updated: Jan 17, 2019, 06:35 AM IST I am 45 years old and I want to buy term life insurance policy. I have undergone treatment for cancer and am completely cured now. Will I get a life insurance policy? For how much amount should I buy? My annual income is Rs 25 lakh. – Tushar Meghraj I will recommend you apply with a life insurance company.
Insurer may ask for basic income documents for high value coverage
Life Insurance , Thinkstock Share Updated: Jan 9, 2019, 06:35 AM IST While buying a life insurance policy do I have to show the rental income from my property along with my salary income as proof? – Parag Keswani Insurance is a contract of utmost good faith. Hence most of the companies allow issuance of insurance coverage basis declaration (for example income, health, etc) and KYC documents. No income documents are required up to specified sum assured.
LIFE INSURANCE: Insurance Act does not restrict nomination of siblings in policy
Life Insurance , Thinkstock Share Updated: Jan 2, 2019, 06:15 AM IST I have a life insurance policy in my name. I am a bachelor and I want nominate my younger brother as legal heir. In event of my death the policy monies should be paid to my brother. I have every right to nominate in my blood relations. My parents are very old. But the insurance company is asking me why I am not nominating my parents instead of brother? They also said that I cannot nominate my brother as long as my parents are alive.
Update nomination after insured's death using succession certificate
Life Insurance , Thinkstock Share Updated: Dec 26, 2018, 06:35 AM IST My sister passed away without a will. She was in USA with her son. The cremation was also done there. She had an LIC policy in her name. But since there is no nominee LIC is not giving the money. Her son is not interested in coming to India since he is a US citizen. I was the joint holder in her bank accounts since till she shifted to USA and I was helping her with all her finances.
LIFE INSURANCE: Double benefit policy, accident benefit rider have similar advantages
Is it better to buy a double benefit life insurance policy or a life insurance policy with accident benefit rider? – Manan Khanna The benefit offered under the double benefit insurance policy or opting for an accidental benefit rider is same. The major difference between the two is that taking an in-built benefit provides a hassle free approach towards buying an additional benefit.
LIFE INSURANCE: Stay invested with policy unless there is an emergency
I have an endowment policy. The premium paying term was seven years and it is over now. But the maturity of the policy is after 15 years. Can I withdraw the money now? How much will I lose if I withdraw now? – Krishna Bangera As I understand you are left with a few years for your policy to mature and you intend to withdraw the money now. I would answer this question in splits. Firstly, yes you do have an option to withdraw the money by surrendering your policy, however it will attract some deductions.
LIFE INSURANCE: Premium may fall if medical test shows you are healthy
Is medical test mandatory while buying life insurance policy? Will my premium increase after I undergo the medical test? – Sajit Menon The medical test requirement is dependent on the size of the insurance cover, and the product, and can differ from one insurer to the other. The outcome of the medical test does have a bearing on the premium rate, but does not necessarily mean you will have to pay more. If you are in good health, the premium payable is likely to be lower.
Buy life insurance when you start earning, review it later
How much insurance should I buy? I am 28 years old and earning Rs 8 lakh. I am not married and living with my parents. Should I buy now or wait till I am married? – Kushal Dogra One should consider buying life insurance as soon as he or she starts earning or has a financial dependency on them. It would be advisable to consider buying a term cover.
Provide nomination while buying policy to ensure smooth payouts
If I want to change the nominee in my insurance policy do I have to inform the nominee and get his signature? My elder brother who is in Chennai is the nominee in my policy. Now I want to make my wife the nominee – Prateek Kashyap Insurance is a legal contract wherein the nominee is provided the benefits under the policy after the demise of insured. So, it is important that the policyholder provides nomination to avoid any hassles at the pay-out stage.
LIFE INSURANCE: Be extremely prudent while surrendering a policy
The surrender value is different in ULIPs and traditional plans. In ULIPs, the surrender value equals fund value minus surrender charge. The surrender charge reduces every year and after five years, it becomes nil. The product brochure or policy document will have the details of the surrender charges. The surrender charges are decided by IRDAI and don't vary from insurer to insurer.
LIFE INSURANCE: Advisor not legally liable for policy renewal reminder
It is the duty of any life insurance advisor to ensure a smooth and transparent communication with his or her customer regarding all aspects of their insurance policy. As a part of his or her duty, an agent is required to ensure that the customer continues to stay insured through renewals and is expected to exercise due diligence in communication of such renewals. However, in case the advisor is unable to communicate renewal related information, he or she is not legally liable.
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