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Articles by Sunil Singhal
A fluorescent choline kinase alpha inhibitor for intraoperative molecular imaging during resection of canine NSCLC tumors
Reference #1 Abstract Supplementary Materials REFERENCES AND NOTES eLetters (0) Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Abstract Choline kinase α (ChoKα) is a biomarker of lung cancer, is overexpressed in 60% of human pulmonary malignancies, and is associated with an aggressive phenotype and poor clinical outcome.
Sunil Singhal, MD
Articles by Sunil Singhal, MD Sunil Singhal, MD, explained how a fluorescent dye technology helps surgeons see and remove tumors more completely.
A single-chip, dual-gain color–NIR camera for fluorescence-guided lung and breast cancer surgery
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Abstract Near infrared (NIR) fluorescence guided surgery can highlight tumors and sentinel lymph nodes, but most clinical fluorescence imaging systems use multi-camera architectures in which residual color–NIR misregistration can mislocalize fluorescence relative to anatomy, and weak signals often require dimming operating room lights.
By Zhongmin Zhu, Yifei Jin, Anamarija Jankulovska, Goran Kondov, Shuming Nie, Sunil Singhal, Viktor Gruev, Brianna Hajek, Sinisha Stojanovski, Darko Angjushev, Igor Djikovski, Nexhati Jakupi, Risto Colanceski, Imran Ferati, Borce Antevski, Ilir Vela, Despot Despotovski, Natasha Tolevska Dimitrovska, Magdalena Bogdanovska Todorovska, Borislav Kondov
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Nature
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Fibroblast activation protein-targeted near-infrared labeling of cancer-associated fibroblasts in a non-small-cell lung cancer tumor microenvironment
Abstract Intraoperative molecular imaging (IMI) has emerged as a valuable tool for the surgical management of non-small cell lung cancer (NSCLC), enabling detection of otherwise imperceptible pulmonary nodules. However, current IMI tracers target tumor-specific receptors that are heterogeneously expressed across different NSCLC subtypes, limiting their universal applicability.
Clarifying validation terminologies in healthcare - npj Digital Medicine
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Abstract Validation is a cornerstone of reliability and trust in diagnostics, yet discipline-specific assumptions and unspoken contextual differences often lead to miscommunication, misalignment, and avoidable delays. As AI/ML becomes more integrated into healthcare, there is a growing necessity to re-examine how the term validation is used and understood.
By Monika Saini, Fabienne Lucas, Shannon Bennett, Sunil Singhal, Matthew G. Hanna, Norman Zerbe, Roberto Salgado, Jansen N. Seheult, David McClintock, Jochen K. Lennerz, Amanda Dy, Sandra M. Buetow, Andrew J. Bredemeyer, Kim R. M. Blenman, Keith Wharton Jr., M. E. de Baca, Kevin Schap, Staci J. Kearney, Jithesh Veetil, April Khademi
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Nature
Verified
A fibroblast activation protein targeted optical tracer for identifying primary and metastatic sarcoma during resection - EJNMMI Research
All in vitro experiments were performed in triplicate to ensure reproducibility. No samples or animals were excluded from data analysis. Under a University of Pennsylvania Institutional Review Board-approved protocol, histologic specimens from 75 consecutive sarcoma patients were obtained from the Hospital University of Pennsylvania’s Biobank. Samples were prepared and immunostained for FAP using anti-FAP antibody (Abcam, ab53066) [20, 31].
Targeted detection of cancer at the cellular level during biopsy by near-infrared confocal laser endomicroscopy - Nature Communications
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Abstract Suspicious nodules detected by radiography are often investigated by biopsy, but the diagnostic yield of biopsies of small nodules is poor. Here we report a method—NIR-nCLE—to detect cancer at the cellular level in real-time during biopsy. This technology integrates a cancer-targeted near-infrared (NIR) tracer with a needle-based confocal laser endomicroscopy (nCLE) system modified to detect NIR signal.
By Gregory Kennedy, Elizabeth Bernstein Verified, Bilal Nadeem, Ashley Chang, Philip S. Low, Sunil Singhal
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Nature
Verified
Multimodality imaging of Surgicel®, an important mimic of post-operative complication in the thorax | BJR|Open
Mechanism of action of Surgicel Surgicel® is a cellulose-based product that is placed at the site of bleeding intraoperatively to promote hemostasis. This serves as a hemostatic adjunct in the control of local hemorrhage, although the exact mechanism of action is uncertain. When this material saturates with blood, it swells into a brownish or black gelatinous mass, which aids in the formation of a clot (Figure 1). Figure 1. Intraoperative placement of Surgicel.
Techniques for intraoperative evaluation of bowel viability in mesenteric ischemia: A review
Tilsed J.V.T. Casamassima A. Kurihara H. et al. ESTES guidelines: acute mesenteric ischaemia. Eur J Trauma Emerg Surg. 2016; 42: 253-270https://doi.org/10.1007/s00068-016-0634-0 Kougias P. Lau D. El Sayed H.F. Zhou W. Huynh T.T. Lin P.H. Determinants of mortality and treatment outcome following surgical interventions for acute mesenteric ischemia. J Vasc Surg. 2007; 46: 467-474https://doi.org/10.1016/j.jvs.2007.04.045 Lehtimäki T.T. Kärkkäinen J.M. Saari P. Manninen H. Paajanen H. Vanninen R.
Near‐infrared imaging and optical coherence tomography for intraoperative visualization of tumors
INVITED REVIEW David Holt BVSc, DACVS Corresponding Author E-mail address: dholt@vet.upenn.edu Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania Correspondence David Holt, Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania.
Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer
Although preclinical models using implanted tumors in mice are valuable, they cannot completely recapitulate the early stages of natural tumor development in humans. To better understand how monocytes and macrophages influence developing tumor immunity, Singhal et al. studied samples from patients with early-stage lung cancer. They phenotyped monocytes and macrophages in tumors and adjacent tissue, as well as samples from control subjects without cancer.
Don't Hesitate... Amputate! The Surgical Legacy of Robert Liston
When it came to the art of amputation, few mastered this practice better than 19th century Scottish surgeon Dr. Robert Liston. Dubbed "The Fastest Knife in the West End," Liston was reputed to have been able to complete operations in mere seconds. Unfortunately the recipients of these surgical flurries generally died minutes to hours later....... but at least they caught a heck of a show!
Mouse versus Human Neutrophils in Cancer: A Major Knowledge Gap
Complexities in Understanding the Granulocytes in Human Cancer and Mouse Tumor Models Caveats in Translating Findings from Mouse Tumor Models to Human Cancers Challenges in the Study of Human TANs The power of mouse models has allowed us to generate many fundamental concepts in tumor immunology. However, it is important to keep an open mind about how closely these findings actually translate to human cancers.
Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer
FiguresFigure 1A Subset of TANs with Hybrid Characteristics of Neutrophils and APCs(A) A single-cell suspension was obtained from fresh tumor and the expression of the indicated granulocytic markers was analyzed by flow cytometry on gated live CD11b cells. Total TANs are shown in blue boxes.(B) Flow cytometric analysis of the expression of APC markers on gated CD11b+CD15hiCD66b+ TANs. The representative cytomorphology of canonical (green boxes) and APC-like hybrid TANs (red boxes) in NSCLC.
The Future of Surgical Oncology: Image-Guided Cancer Surgery
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
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