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Articles by Thomas Quertermous
Vascular smooth muscle cell state trajectories mediate molecular mechanisms of coronary disease risk
Abstract Vascular smooth muscle cells contribute to heritable coronary artery disease risk and undergo complex transitions to multiple disease-related phenotypes. To investigate the genetic basis of these trajectories, we develop a dense timecourse single-cell transcriptomic and epigenetic map of atherosclerosis in a murine disease model accompanied by high-plex in situ spatial data.
Decoding human cardiovascular development and disease through single-cell transcriptomic and epigenomic profiling
Keywords single cell cardiovascular transcriptomics epigenomics cell state congenital heart disease coronary artery disease Get full text access Log in, subscribe or purchase for full access. References 1. Han, X. ... Mapping human pluripotent stem cell differentiation pathways using high throughput single-cell RNA-sequencing Genome Biol. 2018; 19:47 2. Picelli, S. Single-cell RNA-sequencing: the future of genome biology is now RNA Biol. 2017; 14:637-650 3. Shalek, A.K. ...
von Willebrand Factor Is Produced Exclusively by Endothelium, Not Neointima, in Occlusive Vascular Lesions in Both Pulmonary Hypertension and Atherosclerosis
Originally publishedhttps://doi.org/10.1161/CIRCULATIONAHA.121.058427Circulation. 2022;146:429–431 Footnotes References 1. Wagner DD . Cell biology of von Willebrand factor.Annu Rev Cell Biol. 1990; 6:217–246. doi: 10.1146/annurev.cb.06.110190.001245CrossrefMedlineGoogle Scholar 2. Lip G, Blann A . von Willebrand factor: a marker of endothelial dysfunction in vascular disorders?Cardiovasc Res. 1997; 34:255–265. doi: 10.1016/s0008-6363(97)00039-4CrossrefMedlineGoogle Scholar 3.
Author Correction: Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk - Nature Genetics
Correction to: Nature Genetics https://doi.org/10.1038/s41588-022-01069-0, published online 19 May 2022. In the version of this article initially published, Johan L. M. Björkegren’s surname was misspelled as Björkgren. The error has been corrected in the HTML and PDF versions of the article. Author information Author notes These authors contributed equally: Adam W.
Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk - Nature Genetics
Abstract Coronary artery disease (CAD) is a complex inflammatory disease involving genetic influences across cell types. Genome-wide association studies have identified over 200 loci associated with CAD, where the majority of risk variants reside in noncoding DNA sequences impacting cis-regulatory elements.
1,2 na1, Brunilda Balliu3 na1, Daniel Nachun4,5, Theresia M. Schnurr6, Matthew G. Durrant4, Erik Ingelsson6, Martin Wabitsch7, Thomas Quertermous6,8, 2,4, Joshua W.
Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping
Quanyi Zhao1, Michael Dacre2, Trieu Nguyen1, Milos Pjanic1, Boxiang Liu1,2, Dharini Iyer1, Paul Cheng1, Robert Wirka1, Juyong Brian Kim1, Hunter B.
Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis
Abstract In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation. However, the phenotype of modulated SMCs in vivo during atherosclerosis and the influence of this process on coronary artery disease (CAD) risk have not been clearly established.
IGF1 Gene Is Associated With Triglyceride Levels In Subjects With Family History Of Hypertension From The SAPPHIRe And TWB Projects
IGF1 Gene Is Associated With Triglyceride Levels In Subjects With Family History Of Hypertension From The SAPPHIRe And TWB Projects 1. The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. 2. Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Taiwan. 3.
Advances in Transcriptomics
Whole-genome transcriptional profiling has become a standard genomic approach to investigate biological processes. RNA sequencing (RNAseq) in particular has witnessed myriad applications in genetics and various biomedical fields. RNAseq involves a relatively simple experimental protocol of RNA extraction and cDNA library preparation and, because of decreasing next-generation sequencing cost and lower computational burden for data processing, has obtained a central role in the modern biology.
Circulating peptide prevents preeclampsia
Preeclampsia (PE) is a devastating complication of pregnancy that puts both mother and child at risk for clinical complications. In severe cases, PE can progress to multi-organ dysfunction and death. Characterized by hypertension (high blood pressure) and proteinuria (protein in the urine), the syndrome occurs in up to 8% of pregnancies.
Clinical Interpretation and Implications of Whole-Genome Sequencing
Importance Whole-genome sequencing (WGS) is increasingly applied in clinical medicine and is expected to uncover clinically significant findings regardless of sequencing indication. Objectives To examine coverage and concordance of clinically relevant genetic variation provided by WGS technologies; to quantitate inherited disease risk and pharmacogenomic findings in WGS data and resources required for their discovery and interpretation; and to evaluate clinical action prompted by WGS findings.
Coronary Artery Disease and Its Risk Factors
Coronary artery disease (CAD) is the world-wide leading cause of death not only in high-income countries but also increasingly in developing countries.1 Although death rates from CAD have decreased in most high- and middle-income countries in the past 2 decades, there are worrying signs of a lessening trend in the United States,2 and the dramatic increases of world-wide obesity3 and diabetes mellitus1 prevalences emphasize the need for improved preventive and therapeutic strategies to battle...
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