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ArticleOnline nowOpen access Affiliations & Notes 1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, 94158, United States of America 2UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA, 94158, United States of America 3Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, United States of America 4Department of Electrical Engineering and...
Keywords neurodegeneration proteostasis protein aggregation tau CRISPR screen CUL5 SOCS4 Introduction Tauopathies, which include Alzheimer’s disease (AD), are neurodegenerative diseases that are defined by aggregation of the protein tau and that are lacking effective therapeutics. Tau is an intrinsically disordered protein, and its canonical function is to regulate the stability and dynamics of microtubules.
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