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Articles by Thomas Ulas
Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence
Abstract Aging-associated loss of chromatin compaction is linked to derepression of retrotransposable elements (RTEs) in mouse and human tissues. Whether such RTE transcription contributes to the microglia activation that is common in aged brains is unknown. Here, we show that DAXX, a histone chaperone and RTE repressor, is downregulated during aging, preserves microglia homeostasis and inhibits cellular senescence.
TGF-β and IL-2 differentially shape T follicular regulatory cell differentiation and stability in vitro
Abstract T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells play critical roles in regulating the activity of the germinal center (GC), which is essential for the generation of high-affinity antibodies. In the GC, Tfh cells help B cells to proliferate and to differentiate into memory B cells and long-lived plasma cells.
Semantic alignment of the German Human Genome-Phenome Archive metadata model in Europe’s genomics field - Scientific Data
Abstract Legal and technical developments drive data sharing via federated infrastructures, especially in the field of human omics. This requires interoperability across technical, syntactic, organizational, and semantic layers. The German Human Genome-Phenome Archive (GHGA) has been building a national, federated infrastructure for secure sharing of human omics data.
S100-alarmins, antenatal corticosteroids and the risk of late-onset sepsis in preterm infants: A prospective cohort study
Loading metrics Open Access Peer-reviewed Research Article Citation: Kessler G, Ulas T, Vogl T, Roth J, Albrecht F, Hansen G, et al. (2026) S100-alarmins, antenatal corticosteroids and the risk of late-onset sepsis in preterm infants: A prospective cohort study. PLoS One 21(1): e0341544.
Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature
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Abstract Kupffer cells (KCs) are tissue-resident macrophages that colonize the liver early during embryogenesis1. Upon liver colonization, KCs rapidly acquire a tissue-specific transcriptional signature, mature alongside the developing liver and adapt to its functions1,2,3.
By Hao Huang, Lea Seep, Maria Viola, Eliana Franco Taveras, Nikola Makdissi, Jelena Zurkovic, Amir H Kayvanjoo, Klaus Wunderling, Malin Jessen, Lukas Kenner, Thomas Ulas, Stephan Grein, Charlotte Scott, Zhaoyuan Liu, Florent Ginhoux, Marc Beyer, Christoph Thiele, Felix Meissner, Dagmar Wachten, Kerim Acil, Diana Fink, Seyhmus Bayar, Katharina Mauel, Carolin Radwaniak
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Nature
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IL-17A-producing NKp44(−) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue - Nature Communications
Abstract Familial adenomatous polyposis (FAP) is an inherited gastrointestinal syndrome associated with duodenal adenoma formation. Even among carriers of the same genetic variant, duodenal phenotypes vary, indicating that additional factors, such as the local immune system, play a role. We observe an increase in duodenal IL-17A(+)NKp44(−) innate lymphoid type 3 cell (ILC3) in FAP, localized near the epithelium and enriched in adenomas and carcinomas.
Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition
1 Introduction V delta 2 (Vδ2) T cells are the predominant population of unconventional γδ T cells in human peripheral blood. The T cell receptor (TCR) of Vδ2 T cells is composed of Vδ2 and Vγ9 chains and recognises non-peptide molecules such as isopentenyl pyrophosphate IPP [1, 2] and microbe-derived (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) in the context of butyrophilins in an MHC molecule unrestricted manner [3-5].
Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial - Nature Medicine
Abstract African heritage diets are increasingly being replaced by Western-style dietary patterns because of urbanization, economic development, increased access to processed foods, globalization and changing social norms. The health consequences of this nutrition transition are not well understood.
LLM4GRN: Discovering Causal Gene Regulatory Networks with LLMs -- Evaluation through Synthetic Data Generation
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A guide to systems-level immunomics - Nature Immunology
Human immunology has already benefited substantially from omics technologies, such as the large endeavors of the Human Immunology Project Consortium48, the ImmVar study49, the Human Functional Genomics Project40,50 and the Milieu Intérieur study51, to study the variability of the human immune system and to better characterize genotype-phenotype associations.
Swarm Learning for decentralized and confidential clinical machine learning - Nature
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Abstract Fast and reliable detection of patients with severe and heterogeneous illnesses is a major goal of precision medicine1,2. Patients with leukaemia can be identified using machine learning on the basis of their blood transcriptomes3. However, there is an increasing divide between what is technically possible and what is allowed, because of privacy legislation4,5.
By Stefanie Warnat-Herresthal, Hartmut Schultze, Sathyanarayanan Manamohan, N. Ahmad Aziz, Florian Tran, Nicolas Casadei, Christian Herr, Fabian Kern, Tobias Fehlmann, Max Augustin, Lorenzo Bonaguro, Elena De Domenico, Andreas Keller, Mihai G. Netea, Fabian J. Theis, Anna C. Aschenbrenner, Thomas Ulas, Evangelos J. Giamarellos-Bourboulis, Matthijs Kox, Joachim L. Schultze, Vishesh Garg, Christian Siever, Heidi Theis, Ingo Kurth, Becker Matthias
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Nature
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Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
1,2,3,4 na1, Maria Mouktaroudi5 na1, Benjamin Krämer6 na1, Marie Oestreich3 na1, Nikolaos Antonakos5 na1, 3 na1, Konstantina Gkizeli5 na1, Lorenzo Bonaguro3 na1, Nico Reusch3 na1, Kevin Baßler3 na1, Maria Saridaki5 na1, Rainer Knoll3 na1, Tal Pecht3 na1, Theodore S. Kapellos3 na1, Sarandia Doulou3 na1, Charlotte Kröger3 na1, Miriam Herbert3 na1, Lisa Holsten3 na1, Arik Horne3 na1, Ioanna D.
S100A8 and S100A9 are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants
This paper is only available as a PDF. To read, Please Download here. Abstract BACKGROUND & AIMS After birth, the immune system matures via interactions with microbes in the gut. The S100 calcium binding proteins S100A8 and S100A9, and their extracellular complex form, S100A8–A9, are found in high amounts in human breast milk.
Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
We systematically investigated the regulatory effects of the microbiota on the transcriptome and the genome-wide DNA methylation status of IECs from the small intestine of infant, juvenile, and adult mice which were raised in either the presence or absence of a microbiota. This analysis revealed that both the IEC ontogeny and the microbiota affect the epithelial transcriptome signature along with the DNA methylation status and that the microbial effect increases during postnatal development.
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