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Articles by Timothy E. O’Sullivan
Stem-like memory-T maintenance and differentiation into tissue-resident T cells sustain chronic graft-versus-host disease in mice - Nature Communications
Abstract Pathogenic CD4+ memory T cells (Tm) sustain chronic inflammation, but mechanisms remain undefined. Here, we identify four donor-type CD4+ Tm subsets in the target tissues of autoimmune-like chronic graft-versus-host disease in mice: Ly108+CD69− stem-like memory T cells (Tsm), Ly108+CD69+ resident memory progenitor T cells (Trmp), Ly108−CD69+ terminally differentiated tissue-resident T cells (Trm), and Ly108−CD69− intermediate T cells (Tint).
The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors
Keywords natural killer cells unfolded protein response proteostasis dysfunction solid tumors Fli1 metabolism protein aggregate tumor interstitial fluid tumor microenvironment Get full text access Log in, subscribe or purchase for full access. References 1. Lanier, L.L. Evolutionary struggles between NK cells and viruses Nat. Rev. Immunol. 2008; 8:259-268 2. Li, J.H. ∙ O’Sullivan, T.E. Back to the Future: Spatiotemporal Determinants of NK Cell Antitumor Function Front. Immunol. 2022; 12, 816658 3.
Spectacular Award-Winning Photos from the Siena Drone Photo Awards 2025
Photo of the year: “The Lone Horseman” by Dennis Schmelz The Siena Drone Photo Awards 2025 elevate the magic of photography with breathtaking aerial visions. More than a contest, they embody Siena’s mission to prove that creativity still soars. From planes and UAVs to balloons and kites, the competition embraces every form of flight to capture unique perspectives. This year’s winning shots reveal deserts sculpted by wind, glowing cities, misty forests, and oceans that look otherworldly.
Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution - Nature Metabolism
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Abstract Adipose tissue (AT) is a complex connective tissue with a high relative proportion of adipocytes, which are specialized cells with the ability to store lipids in large droplets. AT is found in multiple discrete depots throughout the body, where it serves as the primary repository for excess calories. In addition, AT has an important role in functions as diverse as insulation, immunity and regulation of metabolic homeostasis.
By Anne Loft, Margo P. Emont, Ada Weinstock, Allon Wagner, Bart Deplancke, Boxiang Liu, Camilla Scheele, Chenkai Ma, Christian Wolfrum, Clarissa Strieder-Barboza, Congru Li, Elisabet Stener-Victorin, Esti Yeger-Lotem, Farnaz Shamsi, Jiawei Zhong, Joanna Kalucka, Jutta Jalkanen, Katie L Whytock, Kyle D. Dumont, Lauren M. Sparks, Lucas Massier, Luis R. Saraiva, Marc Beyer, Marcelo A. Mori, Mariana Boroni, Martin Walsh, Mary-Elizabeth Patti, Matthias Blüher, Mikael Rydén, Niklas Mejhert, Peng Gao, Rana K. Gupta, Rinki Murphy, Silvia Corvera, Swapan K. Das, Tao Zhang, Theodore Nelson, Timothy E. O’Sullivan, Yu-Hua Tseng, Susanne Mandrup, Erin E. Kershaw, Hannah X. Hui, Nicole L. Solimini
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Nature
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Amazing Winning Images Of The The 2024 Nature’s Best Photography Awards – Design You Trust — Design Daily Since 2007
Grand Prize: “Bengal Tigers” by Mangesh Ratnakar Desai, India The 2024 Nature’s Best Photography International Awards highlighted breathtaking moments from around the globe, celebrating photographers who captured the beauty and power of Earth’s diverse ecosystems. From sweeping landscapes to intimate wildlife portraits, the award-winning images showcase nature’s grandeur and fragility, inspiring deeper appreciation and awareness for conservation.
Cold versus hot snare endoscopic mucosal resection for large (≥15 mm) flat non-pedunculated colorectal polyps: a randomised controlled trial
Abstract Background and aims Conventional hot snare endoscopic mucosal resection (H-EMR) is effective for the management of large (≥20 mm) non-pedunculated colon polyps (LNPCPs) however, electrocautery-related complications may incur significant morbidity. With a superior safety profile, cold snare EMR (C-EMR) of LNPCPs is an attractive alternative however evidence is lacking. We conducted a randomised trial to compare the efficacy and safety of C-EMR to H-EMR.
Impact of margin thermal ablation after endoscopic mucosal resection of large (≥20 mm) non-pedunculated colonic polyps on long-term recurrence
Abstract Background and aims The efficacy of colorectal endoscopic mucosal resection (EMR) is limited by recurrence and the necessity for conservative surveillance. Margin thermal ablation (MTA) after EMR has reduced the incidence of recurrence at the first surveillance colonoscopy at 6 months (SC1). Whether this effect is durable to second surveillance colonoscopy (SC2) is unknown. We evaluated long-term surveillance outcomes in a cohort of LNPCPs that have undergone MTA.
Cold versus hot snare endoscopic mucosal resection for large (≥15 mm) flat non-pedunculated colorectal polyps: a randomised controlled trial
Abstract Background and aims Conventional hot snare endoscopic mucosal resection (H-EMR) is effective for the management of large (≥20 mm) non-pedunculated colon polyps (LNPCPs) however, electrocautery-related complications may incur significant morbidity. With a superior safety profile, cold snare EMR (C-EMR) of LNPCPs is an attractive alternative however evidence is lacking. We conducted a randomised trial to compare the efficacy and safety of C-EMR to H-EMR.
Regulation of systemic metabolism by tissue-resident immune cell circuits
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The Rhino: An Inventor’s Visionary Solution for Off-Road and Highway Transportation From The 1950s – Design You Trust
Rhino’s tilting hemispheroidal wheels adjust to variable heights on uneven terrain. Back in 1954, inventor Elie Aghnides was struck by an idea that would revolutionize the way we think about off-road vehicles. As he watched a caterpillar tractor muscling dirt around in New York City’s Central Park, he couldn’t help but wonder why such a powerful machine was limited to a maximum speed of 25 mph and plagued by frequent tread breaks.
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences - Nature Immunology
NK sexual dimorphism is independent of gonadal sex hormones A recent investigation examining spleens of C57BL/6 mice reported increased numbers of NK cells in males versus females19. Consistent with these data, we observed that splenic NK cells (identified as CD3−TCRβ−NK1.1+; Extended Data Fig. 1a) are increased in frequency (Fig. 1a,b) and absolute numbers (Fig. 1c) in male C57BL/6 mice compared to females.
Unusual Japanese Sunglasses of 1966 – Design You Trust
In 1966, Japan introduced some unique and unusual sunglasses that caught the attention of fashion enthusiasts worldwide. These sunglasses were unlike anything seen before and included designs such as “lime glasses” and “feet glasses.” h/t: vintag.es Despite their unconventional appearance, these sunglasses were still able to make the wearer look polished and put-together.
Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes
Highlights • Activated liver ILC1s have a protective role in acute liver injury • DNAM-1 is required for activation and IFN-γ production of liver ILC1s • ATP accelerates IL-12-driven IFN-γ production by liver ILC1s • ILC1-derived IFN-γ helps the survival of hepatocytes through upregulation of Bcl-xL Summary Although type 1 innate lymphoid cells (ILC1s) have been originally found as liver-resident ILCs, their pathophysiological role in the liver remains poorly investigated.
4 Major Military Events That Happened On Christmas
On Christmas Day every year, many Americans relax and enjoy time with their families. For many of our troops, though, it can be a day of sacrifice and hardship. Over the history of the U.S., several big military actions have taken place on December 25. Here are four noteworthy ones. 1776: Washington’s Famous Crossing of the Delaware The winter of 1776 didn’t start as a good one for Gen. George Washington’s Continental Army.
Stuning Entries For The 2018 Nat Geo Travel Photographer Of The Year Contest
“Coordillera”. “After this shot, I have been traveling the same route several times. I could not see the landscape I saw when I shot this picture again. That morning the light and shadows over the coordillera were just perfect. The moment I had to shoot this series will remain in my memory as a special gift from nature”. (Photo by Karsten Hoenack/National Geographic Travel Photographer of the Year Contest) “Nakameguro Cherry Blossoms”.
Fantastic Baroque-Style Underwater Photos By Christy Lee Rogers
Hawaii-based artist Christy Lee Rogers uses water as a medium to produce amazing photographs that resemble Baroque paintings. Boisterous in color and complexity, Rogers applies her cunning technique to a barrage of bodies submerged in water during the night, and creates her effects using the refraction of light.
These Powerful Images Capture The Spear-Wielding Tribes Of Papua New Guinea Who Believe They Are Possessed With The Spirit Of The Crocodile
These powerful images capture the spear-wielding tribes of Papua new Guinea who believe they are possessed with the spirit of the crocodile. They show how the Kangunaman clansmen scar their backs to resemble reptile scales while the Huli Wigmen wear elaborate headdresses to signal they are ready for battle. The Kunai men – armed with spears, bows and axes – are pictured with striking red, black and yellow paint on their faces.
NK Cell Responses Redefine Immunological Memory
Immunological memory has traditionally been regarded as a unique trait of the adaptive immune system. Nevertheless, there is evidence of immunological memory in lower organisms and invertebrates, which lack an adaptive immune system.
Atg5 Is Essential for the Development and Survival of Innate Lymphocytes
Autophagy Is Required for Lymphocyte Survival following Homeostatic Proliferation but Is Dispensable in Lymphoreplete Mice Induction of Autophagy by Metformin Enhances Lymphocyte Survival following Homeostatic Proliferation To study the functional relevance of increased autophagic activity in lymphocytes during lymphopenia without the confounding developmental defects, we utilized mice with either inducible deletion of the essential autophagosome machinery component Atg5 (UbcCre-ERT2 ×...
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