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Articles by Timothy Olson
High-resolution single-cell mapping of clonal hematopoiesis and structural variation in aplastic anemia
Abstract Aplastic anemia (AA) results from T-cell-mediated destruction of hematopoietic stem and progenitor cells (HSPCs), driving clonal hematopoiesis via loss of human leukocyte antigen (HLA) risk alleles (HLA loss-of-function mutations or uniparental disomy 6p, UPD6p), paroxysmal nocturnal hemoglobinuria and clonal hematopoiesis of indeterminate potential (CHIP) mutations.
Development and validation of the predictive aplastic score system (PASS): a simplified tool to diagnose acquired aplastic anemia in adults
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Abstract Acquired aplastic anemia (AA) can present similarly to inherited bone marrow failure syndromes (IBMFS) but treatment differs. AA diagnosis relies on excluding IBMFS; however, genetic testing is not always available, may delay care or be inconclusive. We developed the Predictive Aplastic Score System (PASS), a clinical tool using readily available data to distinguish AA from IBMFS in adults. The training cohort included 212 adults (162 AA, 50 IBMFS).
By Gabriel Aleixo, Jiayin Zheng, Jimmy Lee, Eleonore Kaphan, Wei-Ying Jen, Mia Djulbegovic, Jairo Matthews, Tapan M Kadia, Timothy Olson, Regis de Latour, Flore Sicre de Fontbrune, Taha Bat, Courtney DiNardo, Daria V. Babushok, HeeJin Cheon, Stephanie Soewito, Neha Kalakuntla, Sumasri Kotha, Alex Rupsee
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Nature
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Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip
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Keywords hematopoiesis bone marrow immune cells organ-on-a-chip microphysiological systems in vitro models drug testing lung-on-a-chip hematopoietic stem cells myelosuppresion Get full text access Log in, subscribe or purchase for full access. References 1. Kiel, M.J. ∙ Radice, G.L. ∙ Morrison, S.J. Lack of Evidence that Hematopoietic Stem Cells Depend on N-Cadherin-Mediated Adhesion to Osteoblasts for Their Maintenance Cell Stem Cell. 2007; 1:204-217 2. Dagher, R.N. ∙ Hiatt, K. ∙ Traycoff, C. ...
By Andrei Georgescu, Jonathan H. Galarraga, Thomas Marion Cantrell, Samira K. Mehta, Timothy Olson, Pouria Fattahi, Anni Wang, Pelin Candarlioglu, Michele M. Kim, Jeongyun Seo, Eric S. Diffenderfer, Anthony Lynch, Dan Dongeun Huh, Joseph Hai Oved, Brian M. Dulmovits, Asli Muvaffak, Sezin Aday Aydin, G. Scott Worthen
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Cell Stem Cell
Verified
What women can do when most abortions are banned in Iowa Original
Dr. Timothy Olson is a psychiatrist practicing in Des Moines and a lifelong Iowa resident. The Iowa Supreme Court ruled June 28 that the state can hijack a woman’s body if it has a reason (“rational basis”). This means that the "fetal heartbeat" law, passed last year by the Republican-controlled Legislature and signed by the governor, can soon take effect. The law is intended to force a woman (or girl) to bear a child. Pregnancy and childbirth threaten the health of the woman.
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation | Nature Genetics
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Abstract Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD.
By David Adlam, Takiy-Eddine Berrandou, Adrien Georges, Christopher Nelson, Chris Finan, Siiri E. Iismaa, Xiang Zhou, Stephen Hamby, Liam R. Brunham, Stéphanie Debette, Philippe Amouyel, Jeffrey W. Olin, Stephanie E. Hesselson, Stavroula Kanoni, Krishna G. Aragam, Adam S. Butterworth, Nicolas Combaret, Diane Fatkin, Aroon Hingorani, Jacqueline Saw, Tom Webb, Sharonne N. Hayes, Xia Yang, Timothy Olson, Jason C. Kovacic, Robert Graham, Peter S. Braund
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Nature
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Whole Genome Sequencing in Hypoplastic Left Heart Syndrome
Open AccessPerspective by Jeanne L. Theis 1 and Timothy M. Olson 1,2,3,* 1 Cardiovascular Genetics Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA 2 Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN 55905, USA 3 Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA * Author to whom correspondence should be addressed.
Opinion: Why Mom asks if I remembered the kids' mittens
“Did you clip the kids’ fingernails?” my wife, Toni, asked. “Yes,” I replied. “Thumbs, too?” What an odd question! Toni and I shared parenting chores for our two toddlers, and when I clipped fingernails, I never skipped the thumbs. I considered a smart aleck retort, “Do you mean the stubby, fat ones on the end?” or “Whoa, I didn’t sign up for thumbs!” but settled on the safe, “Yes, thumbs, too.” But I was puzzled. Were thumbnails known to be particularly gnarly to trim?
Pro-life and pro-choice advocates can work together to reduce abortion
Timothy Olson, Guest columnist Published 10:47 a.m. CT April 23, 2019 Iowa Supreme Court rejects 72 hour abortion waiting period Des Moines Register Is it time for pro-life and pro-choice advocates to work together to reduce abortion? I grew up Catholic, attending Catholic schools for 12 years. I grew up believing abortion was murder because at conception, God endowed every zygote with an immortal soul. Later I had doubts. Why was the Bible so vague on abortion? Why did Jesus say nothing about it?
Fetal heartbeat bill disregards religious freedom
With their fetal heartbeat bill, Republican lawmakers aim to force their religious beliefs on the women of Iowa [Senate OKs abortion ban if heartbeat is detected, March 1]. These Republicans are the same folks who claim to value religious freedom. The heartbeat is just another milestone of embryonic development, distinguished mainly by making noise. A heartbeat does not make an embryo a person. Mammals, birds, reptiles and fish all have heartbeats.
Letter: Murder victim wouldn't advocate for the death penalty
Unlike Mr. Moser, I knew the victim. Sam Traut isn't remembered as vengeful or vindictive. He is remembered as caring, compassionate and always concerned with the good of others. First and foremost, Sam is remembered as a man of God.Sam was no "snowflake" as Mr. Moser accuses those with "misplaced compassion." Sam was a man deeply concerned with helping people come to know the living God.Sam would not be insulted that Ashley Hunter lives.
In a fire, do you save zygote or baby first?
Joel Kurtinitis reminds us that a zygote is a living entity with a full set of chromosomes [On abortion, liberals cite science fiction, April 9]. So far, so good. He then commits the usual pro-life error of conflating life with personhood. Suppose a fire breaks out in a fertility clinic. Who (or what) do you save first, a baby or a zygote? A baby or a cooler full of zygotes? We all know the difference between a baby and a zygote. One thinks and feels, the other divides and grows.
Clinton's gender is at the heart of 2016 election
“Why aren’t I 50 points ahead?” wonders Hillary Clinton. She might as well wonder why a woman has never been president. This election pits a very strong Democratic candidate, a woman, against a very weak Republican candidate, a man. And it’s still close. Hillary Clinton offers a lifetime of public service as a children’s advocate, first lady of Arkansas and the country, U.S. senator, and secretary of state.
Abortion is a safe procedure
A woman’s chances of dying from an abortion are about 1 in 150,000. Abortion is an extremely safe procedure. Maggie DeWitte of Iowans for Life disagrees [Access to abortion trumps women’s health, July 8]. She defends the onerous Texas restrictions on abortion providers recently condemned by the Supreme Court. DeWitte says she is concerned about women’s safety, but Texas averages only 0.5 abortion deaths per year. Texas averages 17 dentistry deaths per year. Where is her outrage over dentistry?
Rep. Young knew better than to change his vote on LGBT
Timothy Olson, West Des Moines, Letter to the Editor 12:03 a.m. CDT May 26, 2016Buy PhotoCongressman David Young talks about the U.S. flag representing freedom Saturday, March 12, 2016, as he speaks to delegates and party supporters at the Polk County Republican convention at Valley Southwoods Freshman High School in West Des Moines.(Photo: Michael Zamora/The Register)Buy PhotoU.S. Rep. David Young voted against banning LGBT discrimination by federal contractors.
Donald Trump is 'new' to pro-life movement
Poor Donald Trump. New to the pro-life movement, he mistakenly told the truth [Trump flips on abortion remark that women face punishment, USA Today, March 31]. Pro-life leaders quickly corrected him. Before the correction, Trump said that if abortion is outlawed, guilty women should be punished. This is the truth. How can they not be considered culpable? Pro-life groups understand that Americans would not tolerate seeing their mothers, wives, sisters, and daughters sent to prison.
States with assisted suicide don't have highest rates
The Rev. Msgr. Frank E. Bognanno asks how physician-assisted suicide changed Oregon’s culture and answers that the Oregon suicide rate is now 41 percent higher than the U.S. rate [Assisted suicide bill raises hard questions, March 10]. He fails to mention that when assisted suicide was legalized in 1994, the rate was 42 percent higher. Bognanno also fails to mention that states with assisted suicide do not have the highest suicide rates.
The North Face Endurance Challenge
If you're new here, you may want to subscribe to this blog via email. Thanks for visiting! To describe the emotions that coursed through my body on this past weekend’s run is not an easy task. I needed to work through some things and crack open my heart to find the joy in running again. I have been on numerous runs this past year and this past weekend brought back something that was missing from previous runs. I guess I like to run hard, push my limits and get the best out of myself.
There's no humor in pigs squealing
With her political ad "Squeal," Joni Ernst forever linked herself with hog castration, one of the most brutal practices in animal agriculture ("Ernst, Strategist Dish on Making of "Squeal," Nov. 16). The ad was supposed to be funny. Male hogs are castrated to keep their meat from smelling bad. The procedure is carried out by non-veterinarians in non-sterile conditions without anesthesia. It is painful. If this shoddy procedure is not OK for a cat or dog, why is it okay for a hog?
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