Skip To Main Content
Tristen Wright on Muck Rack

Tristen Wright

As seen in: Nature, Cell Press
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile
Back to Tristen Wright’s profile

Articles by Tristen Wright

Mitochondrial integrated stress response activation creates a therapeutic vulnerability to MCL-1 inhibition in acute myeloid leukemia

|
By Amit Budhraja, Peter Hall, Yonghui Ni, Dennis Voronin, Oliver Grant-Chapman, Tresor Mukiza, Tristen Wright, Yong-Dong Wang, Sandi Radko-Juettner, Shondra M. Pruett-Miller, Stanley Pounds, Peter Vogel, Joseph T. Opferman, Lauren Brakefield-Laird, Dixie Brewington, Jamila Moore, Josi Lott
| Nature Verified
Abstract MCL-1 (myeloid cell leukemia-1) promotes survival and confers therapeutic resistance in acute myeloid leukemia (AML), particularly in high-risk subtypes harboring KMT2A rearrangements (KMT2A-r). Clinical trials involving patients with hematological malignancies treated with MCL-1 inhibitor monotherapy have been hampered by dose-limiting toxicity and poor response rates.
Open in Who Shared Issue with article?

Dominant clones leverage developmental epigenomic states to drive ependymoma

|
By Alisha Kardian, Hua Sun, Siri Ippagunta, Nicholas Laboe, Srinidhi Varadharajan, Kwanha Yu, Hsiao-Chi Chen, Tuyu Zheng, Jon P. Connelly, Yong-Dong Wang, Jiangshan Zhan, Hengxi Liu, Kimberley Lowe, Taylor Bugbee, Rakesh Pathak, Amanda Bland, Sanya Mehta, Amir Arabzade, Blake Holcomb, Tristen Wright, David S. Gee, Yi Xiao, Samuel K. McBrayer, Thomas E. Merchant, Jun Qi, Adam D. Durbin Verified, Lindsay A. Schwarz, Li Wang, Andrew M Donson, Nicholas Foreman, Sameer Agnihotri, Alfonso Lavado, Suzanne Baker, David Ellison, Hyun Lee, Shondra M. Pruett-Miller, Kelsey C. Bertrand, Benjamin Deneen, Stephen Mack, Erik Emanus, Riley M. Deneen, Sophie Cochiolo, Kaitlin M. Budd, Gabriele Kembuan, Emma Caesar, Amelia Hancock, Joel Murdoch
| Nature Verified
Abstract ZFTA–RELA is the most recurrent genetic alteration seen in paediatric supratentorial ependymoma (EPN) and is sufficient to initiate tumours in mice1. Despite its oncogenic potential, ZFTA–RELA (ZR) is observed nearly exclusively in childhood EPN, with tumours located distinctly in the supratentorial brain of the central nervous system1.
Open in Who Shared Issue with article?

Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1

|
By Tristen Wright, Christy R. Grace, XIAO LI
| Cell Press Verified
Anti-apoptotic BCL-2 family members in development. Cell Death Differ. 2018; 25: 37-45 Non-apoptotic functions of BCL-2 family proteins. Cell Death Differ. 2017; 24: 1348-1358 Nijhawan D. Fang M. Traer E. Zhong Q. Gao W. Du F. Wang X. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev. 2003; 17: 1475-1486 Zhong Q. Gao W. Du F. Wang X. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell.
Open in Who Shared Issue with article?
Show More