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Tsutomu Sawai

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Articles

A binding ban, and its limits: Japan legislates on heritable human genome editing

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By Tsutomu Sawai
| Nature Verified
On 17 July 2026, Japan enacted the Act on Regulation of Handling of Human Genome-Edited Embryos, etc., promulgated a week later as Act No. 70 of 2026 (ref. 1). The 2018 announcement of gene-edited births in China2 brought the issue to global attention. Some 70 countries prohibit heritable (germline) human genome editing outright, although scope and enforceability vary widely3.
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Drawing lines: how the public defines “Serious” genetic conditions for reproductive testing

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By Shizuko Takahashi, Serene Ong, Tianxiang Lan, Tsutomu Sawai, Rie Iizuka
| Nature Verified
Abstract Prior normative and empirical research has identified a gap between how patients and the public conceptualize “serious” conditions eligible for preimplantation genetic testing for monogenic disorders (PGT-M) and how seriousness is defined. Japan represents a highly restrictive regulatory context shaped by its historical experience with eugenics.
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Ethics must keep pace with embryo research

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By Tsutomu Sawai
| Nature Verified
CORRESPONDENCE 28 October 2025 In August, Japan’s bioethics panel backed producing embryos from sperm and eggs derived from stem cells, in anticipation of formal approval. The approach is not yet feasible with human cells — but these embryos could eventually be studied for up to 14 days in the laboratory. The research could advance understanding of fertilization, improve assisted reproduction and support genetic research.
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