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Articles by Tunan Chen
Pharmacological activation of WASp potentiates macrophage phagocytosis and enhances ibrutinib efficacy against mouse models of brain tumors
Editor’s summary Penetrating the blood-brain barrier and activating the immune system are two main barriers of current therapies to treat primary and metastatic brain malignancies. Here, Cheng et al. evaluate repurposing ibrutinib, a blood-brain barrier penetrating the tyrosine kinase inhibitor (TKI) to target and activate its effect on tumor-associated macrophages (TAMs).
Long-range cholinergic input promotes glioblastoma progression
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Keywords glioblastoma rabies virus neuro-glioma interaction diagonal band of Broca cholinergic input glutamatergic input neural circuit manipulation CHRM3 scopolamine donepezil Get full text access Log in, subscribe or purchase for full access. References 1. Mancusi, R. ∙ Monje, M. The neuroscience of cancer Nature. 2023; 618:467-479 2. Winkler, F. ∙ Venkatesh, H.S. ∙ Amit, M. ... Cancer neuroscience: State of the field, emerging directions Cell. 2023; 186:1689-1707 3.
By Chuanyan Yang, Xuezhu Chen, Yibin Jiang, Xuejiao Lei, Kang Ma, Yulian Quan, Tianran Li, Chenfu Guo, Yijing Meng, Lin Kang, Xinyu Zhang, Long Jin, Jiafeng Huang, Ning Mu, Zexuan Yan, Qinghua Ma, Shuai Wang, Yanxia Wang, Yong-Ning Shang, Cong Chen, Yu Shi, Shukun Hu, Likun Yang, Chuan Lan, Rong Hu, Ying Zhang, Xia Li, Yunqing Li, Chong Liu, Yu-Hai Wang, Hua Feng, Xiu-Wu Bian, Tunan Chen
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Cell Press
Verified
Pan-cancer human brain metastases atlas at single-cell resolution
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1Biomedical Pioneering Innovation Center (BIOPIC), Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Peking University (PKU), Beijing, China 2Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China 3Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China 4Guangdong Provincial Key...
By Xudong Xing, Jian Zhong, Jana Biermann, Hao Duan, Xinyu Zhang, Yu Shi, Yixin Gao, Kejun He, Duanyang Zhai, Feng Luo, Yanxing Lai, Feizhe Xiao, Wenying Wang, Mengru Wang, Jianguo Xu, Hao Liu, Jiaze Tang, Liangzhao Chu, Tunan Chen, Edridge D’Souza, Lindsay A. Caprio, Leon Ebel, Devanik Biswas, Azzurra Cottarelli, Yonggao Mou, Benjamin Izar, Nu Zhang, Fan Bai
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Cell Press
Verified
Probing Phosphorylation-Induced Vibrational Couplings in CFTR by 2D IR Spectra Simulations
Abstract Phosphorylation of the regulator (R) domain underlies the basis for gating in the human cystic fibrosis transmembrane conductance regulator (CFTR), malfunction or down regulation of CFTR leads to defective apical chloride transport. The biophysical mechanism that underlies the regulatory effect of R domain is still unclear.
In Situ Photoacoustic Detection System for SO2 in High-Pressure SF6 Buffer Gas Using UV LED
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Application of Excimer Lamp in Quantitative Detection of SF6 Decomposition Component SO2
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