Warrison A. Andrade

Highlights • Leishmania infection triggers the non-canonical activation of the NLRP3 inflammasome • Leishmania lipophosphoglycan (LPG) triggers caspase-11 activation • LPG-deficient Leishmania shows impaired caspase-11 and caspase-1 activation • Caspase-11 is important for restriction of Leishmania infection in macrophages and in vivo Summary Activation of the NLRP3 inflammasome by Leishmania parasites is critical for the outcome of leishmaniasis, a disease that affects millions of people...

Cyclic GMP–AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria Carolina Gallego-Marin, Jacob E. Schrum, Warrison A. Andrade, Scott A. Shaffer, Lina F. Giraldo, Alvaro M. Lasso, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, Douglas T. Golenbock The Journal of Immunology January 15, 2018, 200 (2) 768-774; DOI: 10.4049/jimmunol.1701048

Cyclic GMP–AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria Carolina Gallego-Marin, Jacob E. Schrum, Warrison A. Andrade, Scott A. Shaffer, Lina F. Giraldo, Alvaro M. Lasso, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, Douglas T. Golenbock The Journal of Immunology December 27, 2017, ji1701048; DOI: 10.4049/jimmunol.1701048