Man-Wah Tan

Abstract : Antibiotics found in and inspired by nature are life-saving cures for bacterial infections and have enabled modern medicine. However, the rise in resistance necessitates the discovery and development of novel antibiotics and alternative treatment strategies to prevent the return to a pre-antibiotic era. Once again, nature can serve as a source for new therapies in the form of natural product antibiotics and microbiota-based therapies.

The Acknowledgments section was not published in the article. The Acknowledgments section is: Acknowledgments This work was supported by the European Union’s Horizon 2020 research and innovation program (Grant Agreement No 742720 ). Article Info Publication History Published online: July 20, 2020 Publication stage In Press Corrected Proof Identification DOI: https://doi.org/10.1016/j.tcb.2020.07.001 Copyright © 2020 The Author(s). Published by Elsevier Ltd. All rights reserved.

Highlights Bacteria and viruses have evolved specific ways of targeting mitochondria to perturb mitochondrial function that can prove to be beneficial for these microbes. Many bacteria and viruses use specific virulence mechanisms to modulate mitochondrial dynamics, leading to either mitochondrial fusion or fission. Mitochondrial metabolism can also be impacted by bacterial and viral infections.