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Articles by Weike Li
Modulation of microbiota by traditional Chinese medicine in chronic inflammatory airway disease: a systematic review and meta-analysis of animal studies
Abstract Background: A growing number of studies have indicated that traditional Chinese medicine (TCM) can regulate microbiota in chronic inflammatory airway disease (CIAD). Nevertheless, no systematic review or integrated analysis has summarized relevant evidence to date, limiting the clinical application of TCM in this field. Methods: This study followed the PRISMA reporting guidelines.
Author Correction: Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins
Correction to: Nature Communications https://doi.org/10.1038/s41467-025-64748-6, published online 4 November 2025 In the version of this article initially published, in Fig. 7j and associated Source Data, due to a copy/paste error, data for mouse 12 were inadvertently overwritten by data from mouse 6. The figure and Source Data are now amended in the HTML and PDF versions of the article. For comparison, the original figure is available as Supplementary Information accompanying this amendment.
Longer leukocyte telomere length increases the odds of premature rupture of membranes: a cross-sectional study based on UK Biobank
Abstract This study aimed to explore the association between leukocyte telomere length (LTL) and premature rupture of membranes (PROM). This cross-sectional study included a total of 170,841 participants from the UK Biobank. Restricted cubic spline model (RCS) and logistic regression were used to evaluate the relationship between LTL and PROM. Subgroup analysis and interaction tests were conducted to test the stability of the results.
Association between chronic neck pain and chronic respiratory diseases
Back to Journals » Journal of Pain Research » Volume 18 Original Research Musculoskeletal Pain/Rehabilitation and Neuropathic Pain Authors Yi M, Zhang Z, Li H, Sai J, Li W, Wang Z Received 31 August 2025 Accepted for publication 18 December 2025 Published 30 December 2025 Volume 2025:18 Pages 7275—7286 DOI https://doi.org/10.2147/JPR.S564354 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Alaa Abd-Elsayed Mingyang...
Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins
Abstract Base editing stands at the forefront of genetic engineering, heralding precise genetic modifications with broad implications. While CRISPR-based DNA and RNA base editing systems capitalize on sgRNA-guided specificity and diverse deaminase functionalities, the pursuit of efficient C-to-U RNA editing has been hampered by the inherent constraints of cytidine deaminases.
Tachykinin signaling in the right parabrachial nucleus mediates early-phase neuropathic pain development
Keywords neuropathic pain parabrachial nucleus PBN lateralization tachykinin NK1R early phase hyperalgesia Introduction Neuropathic pain, affecting over 30% of the global population, is notably resistant to treatments.1 Noxious stimuli are detected by the skin and transmitted through afferent nerve fibers to the spinal cord,2 spinal projection neurons are primarily responsible for transmitting this sensory information to the brain.3 Behavior studies have identified several brain regions that...
Cannes Dispatch
The claim that 2024 is a lackluster year for the Cannes Film Festival has been heard throughout the two weeks of the festival, even with body–horror freakout like The Substance or emphatically political thriller The Seed of the Sacred Fig, the latter of which gained a nearly 15–minute emotional standing ovation after its premiere. Most main competition films, according to my fellow journalists, are dull and horribly nostalgic.
Penn 10: Vicki de la Rosa
During the summer of 2020, on a whim, Vicki de la Rosa (C '24) drove 20 hours with her friends from north New Jersey to Florida. Along the journey, they stopped in North Carolina and Savannah, Ga., eventually reaching her grandma’s house in Florida. They drove back after a few days. According to Vicki, this was one of “those spontaneous things” that characterized so much of her college experience.
Art in the Gaza Solidarity Encampment
Art has been an act of resistance throughout the ongoing war in Gaza. As the war has martyred poets, scholars, and artists, there is an exigence to preserve Palestine’s rich cultural legacy of art and scholarship in order to bear testament to its existence. A rallying cry, seared in the public consciousness, came in Refaat Alareer’s poem “If I Must Die,” published after he was killed on December 7th by an Israeli airstrike.
A Conversation on 'The Boy and the Heron'
Review Hayao Miyazaki begs the fundamental question of our existence in his final swan song. Weike: Hayao Miyazaki’s newest entry to his glorious filmography bears every hint of a final swan song. It’s a film with a culmination of everything that fascinates Miyazaki: a young boy’s adventure, a parallel reality, and even planes and his obsession with flying.
Behind the Glamour of a Summer Film Festival
The Cannes Film Festival is addicting. Not just because of the luxurious assemblage of the grandest and most star–studded films of the year, all demanding one's attention, but because it's combined with the frantic atmosphere of a carnival. Covering the festivity for a Chinese media outlet, I attended the 76th Cannes Film Festival this May.
A Strainer-Based Platform for the Collection and Immunolabeling of Mouse Intestinal Organoids
1. Introduction Researchers have accumulated an abundant body of knowledge concerning the challenges posed by different diseases [1,2,3,4], including viral infections, cancers, metabolic disorders, and neurodegenerative diseases. However, there remains deficiencies in both cell and animal research methodologies. Cell research normally focuses on one or several cellular components [5,6] and, thus, cannot well describe biological processes occurring in vivo.
The Impact of ESG Rating on Stock Price Synchronization of Listed Companies: Evidence from China
E3S Web of Conferences 409, 01002 (2023) The Impact of ESG Rating on Stock Price Synchronization of Listed Companies: Evidence from China 1, 1*, 1 and 2 1 School of Business, Sichuan University, Chengdu, 610064, People’s Republic of China 2 School of Economics, Sapienza University of Rome, Rome, Italy * e-mail: zhimin1005@foxmail.com Abstract To explore the latest feedback from the Chinese capital market on listed companies’ ESG evaluation, we construct a two-way fixed-effects model with a...
Microorganisms | Free Full-Text | Lumpy Skin Disease Virus Infection Activates Autophagy and Endoplasmic Reticulum Stress-Related Cell Apoptosis in Primary Bovine Embryonic Fibroblast Cells
Open AccessArticle by Jinlong Tan †, Yinju Liu †, Weike Li , Yongzhi Zhang , Guohua Chen , Yongxiang Fang , Xiaobing He and Zhizhong Jing * State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Veterinary Public Health of Agriculture Ministry Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China * Author to whom correspondence should be addressed. † These authors contributed equally to this work.
What could Possibly be Wrong about Netflix?
Glass Onion: A Knives Out Mystery, The Gray Man, or earlier, Red Notice—these are what Netflix co–chief Ted Sarandos termed as “big event films” and supposedly represent the company’s (I hate to call it a film studio) path forward under a “bigger, better, fewer” refrain after its shocking earnings disclosure last April that resulted in a significant stock value loss.
"A New Old Play": Clown Spirit and Handmade Craftsmanship
The film A New Old Play opens with its protagonist’s death. The audiences follow a rickshaw operated by two demons, Ox–Head and Horse–Face, who are subordinates to the king of Hell (“yanluo wang") and escort the now–dead Qiu Fu into the underworld in Chinese mythology. They find Qiu Fu in a dense fog; he immediately recognizes them as messengers from Fengdu, the capital of Hell, and realizes that he has already passed away.
The newest crime thriller ‘Decision to Leave’ will leave its audience emotionally shattered
The frenzied buzz over Bong Joon–ho’s phenomenal Parasite (2019) seems to have just been yesterday, with both a sweeping victory at the Oscars and the box office (the fourth highest grossing foreign film in the United States).Decision to Leave (2022), a crime thriller from the celebrated Korean auteur Park Chan–wook, was recently released in the United States, and the film has been often described by the press in tandem with Parasite.
2022 New York Film Festival: Full of Under-the-Radar Gems
On Oct. 16, the 60th New York Film Festival (NYFF), presented by Film at Lincoln Center, came to an end after a 17–day cinematic marathon. Featuring a wide range of quirky, subversive, and most importantly, inherently different films from across the world, the festival is a potent testament to the youth of cinematic art and its everlasting appeal, even after the severe effects from the COVID–19 pandemic.
‘Blonde’ Is Anything but an Authentic Representation of Marilyn Monroe
Ten years after his bizarre, stylized neo–noir crime story, Killing Them Softly, Andrew Dominik returns with his newest, almost three–hour long feature film: Blonde. The film, which premiered at the 79th Venice International Film Festival and arrived on Netflix on Sept. 28, has faced heavy criticism over its extreme exploitation and overt simplification of Marilyn Monroe’s tragic life events. The runtime may seem to promise an in–depth, holistic rediscovery of Monroe’s life.
For bitter 'Game of Thrones' fans, 'House of the Dragon' is a thrilling welcome back to Westeros
Imagine Disney+ or Kevin Feige doing a Game of Thrones prequel about House Targaryen. There would be more dragons, for sure. An amusing tour of the dragon pit with a flippant guide is warranted in the first ten minutes of the pilot, including several self–referential jokes. They might even have two dragons spew fire at each other, although no one would be harmed by the end of the episode. Luckily, that’s not the case.
Exposure to ethylparaben and propylparaben interfere with embryo implantation by compromising endometrial decidualization in early pregnant mice
RESEARCH ARTICLE Dan Wang, Laboratory of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing, China Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China Search for more papers by this author Weike Li, Laboratory of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing, China Joint International Research Laboratory of Reproduction & Development, Chongqing Medical...
Constraints of Viral RNA Synthesis on Codon Usage of Negative-Strand RNA Virus
Structure and Assembly Ryan H. Gumpper, Weike Li, Ming Luo Rebecca Ellis Dutch, Editor DOI: 10.1128/JVI.01775-18 ABSTRACT Negative-strand RNA viruses (NSVs) include some of the most pathogenic human viruses known. NSVs completely rely on the host cell for protein translation, but their codon usage bias is often different from that of the host.
Complementary Mutations in the N and L Proteins for Restoration of Viral RNA Synthesis
ABSTRACTDuring viral RNA synthesis by the viral RNA-dependent RNA polymerase (vRdRp) of vesicular stomatitis virus, the sequestered RNA genome must be released from the nucleocapsid in order to serve as the template. Unveiling the sequestered RNA by interactions of vRdRp proteins, the large subunit (L) and the phosphoprotein (P), with the nucleocapsid protein (N) must not disrupt the nucleocapsid assembly.
One-pot synthesis of redox-triggered biodegradable hybrid nanocapsules with a disulfide-bridged silsesquioxane framework for promising drug delivery
Biodegradability is very critical for biomaterials to be nanocarriers. Ideal nanocarriers should be stable enough to execute their functions, but then can be efficiently got rid of, by either biodegradation or excretion. In this work, we report the design and one-pot fabrication of a series of uniform organic–inorganic hybrid nanocapsules with a disulfide-bridged silsesquioxane framework and a particle size smaller than 100 nm for redox-triggered biodegradation.
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