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Articles by Weiwei Han
Valorization of yak bone collagen byproducts: computational screening and experimental validation of anti-aging peptides targeting MMP-1
Abstract Valorization of yak collagen byproducts offers a sustainable route to food-derived bioactive peptides. To prioritize candidate peptides from yak collagen-derived sequences, we developed AgeAttnMLP, an ESM-2-based screening model that achieved an AUC of 0.891 under conventional five-fold cross-validation and 0.879 under an additional cluster-aware grouped evaluation.
AI-guided discovery of fungal-derived salty and saltiness-enhancing peptides for sodium-reduced foods
Abstract Natural salty and saltiness-enhancing peptides are promising candidates for sodium reduction in food systems. This study established an integrated AI-guided workflow combining in silico hydrolysis, embedding-based machine learning, electronic tongue validation, cellular evaluation, molecular docking, and molecular dynamics simulation to identify fungal-derived saltiness-modulating peptides.
Spectral analysis of astragalus based on laser-induced breakdown spectroscopy
Abstract As a classic Chinese medicinal herb with prominent clinical efficacy, Astragalus is widely used for disease prevention and health care, and its elemental composition and contents directly affect the quality and therapeutic effect of herbal materials. This work adopts laser-induced breakdown spectroscopy (LIBS) to carry out elemental analysis on 3-year-old Astragalus herb from Longxi, a representative authentic producing area in China.
Improvement of residual dizziness associated with a low-dose vitamin D-calcium combination (Caltrate D) supplementation in female patients with benign paroxysmal positional vertigo after successful repositioning: an 8-week retrospective study
Abstract Background: Residual dizziness (RD) is a common and debilitating symptom following successful canalith repositioning procedure (CRP) for benign paroxysmal positional vertigo (BPPV). Currently, no effective pharmacological treatment exists for this condition. Our previous work identified low serum 25-hydroxyvitamin D [25(OH)D] as an independent risk factor for RD. This study therefore evaluated whether 8-week supplementation with Caltrate D was associated with improvement in RD.
SRMMP-CharQM, Physics-Informed Deep Learning for Toxicity Prediction: Quantum Mechanical Descriptors Enable Scaffold Hopping in Mitochondrial Membrane Potential Assays Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Disruption of mitochondrial membrane potential (SR-MMP, Stress Response─Mitochondrial Membrane Potential) is a critical toxicity end point in early drug safety assessment.
Exploring the interaction of obesity and allergy and the potential roles of gut microbiota in the development of this comorbidity in male mice
Abstract Plenty of epidemiological studies have focused on obesity and allergic diseases, less is known about the interaction of the comorbidity. The present study was conducted to identify the relationship between obesity and allergy and to clarify the potential regulatory roles of gut microbiota in the development of comorbidity. Four-week-old male BALB/c mice were used to establish the comorbidity model.
EPL
EPL articles are available online as soon as the production process is complete. The currently opened issue will be updated regularly until it is complete. To keep abreast of new articles, you may either visit this page regularly or subscribe to our E-mail alert Volume 152 / No 3 (November 2025) (in progress) Export the citation of the selected articles Export Select all Statistical physics and networks
Stable Isotopic Study on Horse Feeding Strategies in the Zhou Dynasty of Ancient China
References , , and . 2020. “Horse Raising Management and Breeding Techniques.” Heilongjiang Animal Breeding 28, no. 6: 37–40. 1990. “Preparation and Characterization of Bone and Tooth Collagen for Isotopic Analysis.” Journal of Archaeological Science 17, no. 4: 431–451. , and . 1993. “ Experimental Evidence for the Relationship of the Carbon Isotope Ratios of Whole Diet and Dietary Protein to Those of Bone Collagen and Carbonate.” In Prehistoric Human Bone, edited by J. B. Lambert and G. G. Joseph, 1–37.
Network Pharmacology and Bioinformatics Study of Six Medicinal Food Homologous Plants Against Colorectal Cancer
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Hierarchical FeCo LDH/NiSe heterostructure electrocatalysts with rich heterointerfaces for robust water splitting at an industrial-level current density
Hierarchical FeCo LDH/NiSe heterostructure electrocatalysts with rich heterointerfaces for robust water splitting at an industrial-level current density† Sustainable hydrogen production by electrocatalytic water splitting is a promising energy storage technology yet challenging due to the sluggish kinetics of the oxygen evolution reaction (OER).
Thermodynamic study on the phase assemblage of MPC exposed to natural and accelerated carbonation conditions
REFERENCES 1, . Magnesia-based cements: a journey of 150 years, and cements for the future?. Chem Rev. 2016; 116(7): 4170–4204. 2, , , , , , et al. MgO-based cements—current status and opportunities. RILEM Tech Lett. 2023; 8: 65–78. 3, , , , . Magnesia cements. Amsterdam: Elsevier; 2020. p. 334. 4, , , . Hydration behavior of magnesium potassium phosphate cement and stability analysis of its hydration products through thermodynamic modeling. Cem Concr Res. 2017; 98: 101–110. 5, , .
Hierarchical FeCo LDH/NiSe heterostructure electrocatalysts with rich heterointerfaces for robust water splitting at industrial-level current density
Hierarchical FeCo LDH/NiSe heterostructure electrocatalysts with rich heterointerfaces for robust water splitting at industrial-level current density Sustainable hydrogen production by electrocatalytic water splitting is a promising energy storage technology yet challenging due to the sluggish kinetics of the oxygen evolution reaction (OER).
Specific Substrate Activity of Lotus Root Polyphenol Oxidase: Insights from Gaussian-Accelerated Molecular Dynamics and Markov State Models
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Molecules | Free Full-Text | Molecular Dynamics Simulation Combined with Neural Relationship Inference and Markov Model to Reveal the Relationship between Conformational Regulation and Bioluminescence Properties of Gaussia Luciferase
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Synergistically optimizing electrocatalytic performance of IrO2 with double doping and bi-directional strains for acidic oxygen evolution reaction
Synergistically optimizing electrocatalytic performance of IrO2 with double doping and bi-directional strains for acidic oxygen evolution reaction Because of the strong acidic environment and oxidative conditions, realizing the highly active and stable iridium (Ir)-based electrocatalysts toward oxygen evolution reaction (OER) in a proton exchange membrane (PEM) electrolyzer is still a big problem to overcome.
Exploring Bitter and Sweet: The Application of Large Language Models in Molecular Taste Prediction
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Chem. Inf. Model. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Fluorescence color change of supramolecular polymer networks controlled by crown ether‐cation recognition
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Visible Light Mediated Cyclization of Ynones for the Synthesis of 3‐Alkyl N‐Fused Indoles via Csp3−H Bond Functionalization
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Study of the Mechanical Properties and Microstructure of Alkali-Activated Fly Ash–Slag Composite Cementitious Materials
Abstract : Composites that use fly ash and slag as alkali-activated materials instead of cement can overcome the defects and negative effects of alkali-activated cementitious materials prepared with the use of an alkali-activated material. In this study, fly ash and slag were used as raw materials to prepare alkali-activated composite cementitious materials.
Long-Term Prestress Loss Calculation Considering the Interaction of Concrete Shrinkage, Concrete Creep, and Stress Relaxation
Abstract : In order to accurately calculate the long-term prestress losses of prestressed tendons, a time-varying model of long-term prestress loss considering the interaction between concrete shrinkage, creep, and the stress relaxation of prestressed tendons was constructed. Then, a method for calculating the long-term prestress losses of concrete structures was developed. A long-term prestress loss test of a prestressed concrete T-beam in a long-term field test environment was carried out.
Modification Effect of Ca(OH)2 on the Carbonation Resistance of Fly Ash-Metakaolin-Based Geopolymer
2. Experiment Design 2.1. Test Materials and Parameters In this experiment, fly ash and metakaolin were used to prepare composite cementing material geopolymer. Among them, metakaolin a KAOOPOZZ series of highly active metakaolin produced by China Inner Mongolia Chaobrand Building Materials Technology Co., Ltd., fly ash from China Henan Gongyi City Yuanheng water purification materials factory.
Effects of Al/Na and Si/Na Molar Ratios on the Alkalinity of Metakaolin-Based Geopolymer Pore Solutions
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Probing the Mechanisms of Inhibitors Binding to Presenilin Homologue Using Molecular Dynamics Simulations
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Min Wang †, Kaifeng Liu †, Yingying Ma and Weiwei Han * Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China * Author to whom correspondence should be addressed. † These authors contributed equally to this work.
Computer-Aided Screening and Revealing Action Mechanism of Green Tea Polyphenols Intervention in Alzheimer’s Disease
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The Synergistic Activation of Ce‐Doping and CoP/Ni3P Hybrid Interaction for Efficient Water Splitting at Large‐Current‐Density
Abstract The high intermediate (H*, OH*) energy barriers and slow mass/charge transfer increase the overpotential of alkaline water electrolysis at large-current-density. Engineering the electronic structure with the morphology of the catalyst to reduce energy barriers and improve mass/charge transportation is effective but remains challenging.
RL-MLZerD: Multimeric protein docking using reinforcement learning
Introduction Proteins interact with other proteins when they perform biological functions in a cell. Therefore, knowing how proteins physically interact with each other is an essential step toward molecular- and atomic-level understanding of functional mechanisms of proteins. A three-dimensional (3D) picture of individual proteins and protein complexes can be determined by biophysical experiments such as X-ray crystallography and cryogenic electron microscopy.
Neural relational inference to learn long-range allosteric interactions in proteins from molecular dynamics simulations - Nature Communications
Abstract Protein allostery is a biological process facilitated by spatially long-range intra-protein communication, whereby ligand binding or amino acid change at a distant site affects the active site remotely. Molecular dynamics (MD) simulation provides a powerful computational approach to probe the allosteric effect. However, current MD simulations cannot reach the time scales of whole allosteric processes.
Single-Atom-Based Catalysts for Photoelectrocatalysis: Challenges and Opportunities
Single-Atom-Based Catalysts for Photoelectrocatalysis: Challenges and Opportunities Photoelectrocatalysis (PEC) has recently emerged as a promising strategy for utilizing solar energy due to its unique features in combining the merits of electrocatalysis and photocatalysis in solar energy harvesting, charge kinetics and catalytic reactions. However, it still encounters bottlenecks of scarce reaction sites and low product selectivity, restricting its development toward practical application.
Water compatible supramolecular polymers: recent progress
Water compatible supramolecular polymers: recent progress Weiwei Han, *a Wei Xiang,a Qingyun Li,b Hanwei Zhang,b Yabi Yang,b Jun Shi,a Yue Ji,a Sichang Wang,a Xiaofan Ji, *b Niveen M. Khashab c and Jonathan L.
Introduction on Biosafety Law of the People's Republic of China and Linkage Thereof with International and Domestic Regulations
I. Introduction on the Biosafety Law of the People's Republic of China The Biosafety Law of the People's Republic of China (hereinafter referred to as the “Biosafety Law”) was deliberated and approved on October 17, 2020, and will come into effect as of April 15, 2021.
Erratum for Townsend et al., “A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor”
Erratum for Townsend et al., “A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor” Guy E. Townsend II, Weiwei Han, Nathan D. Schwalm III, Xinyu Hong, Natasha A. Bencivenga-Barry, Andrew L. Goodman, Eduardo A. Groisman mBio Mar 2020, 11 (2) e00301-20; DOI: 10.1128/mBio.00301-20
A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor
Research Article | Molecular Biology and Physiology Guy E. Townsend, II, Weiwei Han, Nathan D. Schwalm, III, Xinyu Hong, Natasha A. Bencivenga-Barry, Andrew L. Goodman, Eduardo A. Groisman Laurie E. Comstock, Editor DOI: 10.1128/mBio.03221-19 ABSTRACT Microbial colonization of the mammalian gut is largely ascribed to the ability to utilize nutrients available in that environment.
Formation mechanism of a sea cucumber ovum derived heptapeptide-calcium nanocomposite and its digestion/absorption behavior
Formation mechanism of a sea cucumber ovum derived heptapeptide–calcium nanocomposite and its digestion/absorption behavior Pengbo Cui, Songyi Lin, Weiwei Han, Pengfei Jiang, Bei-Wei Zhu and Na Sun Abstract Asn-Asp-Glu-Glu-Leu-Asn-Lys (NDEELNK), derived from sea cucumber ovum, has shown a prominent calcium-binding ability. In this study, the formation mechanism of NDEELNK-calcium nanocomposite as well as its digestion and absorption behavior were investigated.
Ultra-small Mo2C Nanodots Encapsulated in Nitrogen Doped Porous Carbon for pH-universal Hydrogen Evolution: Insights into the Synergetic Enhancement by Nitrogen Doping and Structure Defects
Ultra-small Mo2C Nanodots Encapsulated in Nitrogen Doped Porous Carbon for pH-universal Hydrogen Evolution: Insights into the Synergetic Enhancement by Nitrogen Doping and Structure Defects Weiwei Han, Lulu Chen, Biao Ma, Jun Wang, Weiyu Song, Xiaobin Fan, Yang Li, Fengbao Zhang and Wenchao Peng Abstract Ultra-small Molybdenum carbide nanodots encapsulated in nitrogen doped porous carbon (Mo2C/N-PC) were synthesized by a facile one-pot method.
Dietary sugar silences a colonization factor in a mammalian gut symbiont
Studies reveal the mechanisms behind tumor metastasis and how to stymie it. But primary tumors still get the lion’s share of researchers’ attention.
Patenting Regenerative Medicine in China | Lexology
Regenerative medicine, which aims at the process of replacing, engineering or regenerating human cells, tissues or organs, so as to restore or establish the normal function of a living organism, is a prospective branch of medicine. Regenerative medicine is popular worldwide in the recent decade, and has broad applications. Many biological companies, research institutions and universities are conducting research in this field.
Intellectual Property in China - No. 36, Dec. 2016
To view this article you need a PDF viewer such as Adobe Reader. If you can't read this PDF, you can view its text here. Go back to the PDF . China's applications for evaluation report of patent for design exceed 20,000....................................................4 The China Trademark Office approved the registration of the first sound trademark filed by a foreign applicant... 4 JEEP vs.
Frontiers | Immunogenicity and safety of an Escherichia coli-produced 9-valent human papillomavirus vaccine (types 6/11/16/18/31/33/45/52/58) in healthy Chinese women aged 20-45 years: a single-center, randomized, observer-blinded, positive controlled pha
CLINICAL TRIAL article Volume 16 - 2025 | https://doi.org/10.3389/fimmu.2025.1706662 1 Introduction The human papillomavirus (HPV) causes premalignant and malignant lesions of the cervix, vagina, vulva, anus, penis, and oropharynx as well as genital warts, which has imposed a substantial disease burden worldwide, especially in developing countries (1, 2). Cervical cancer is the fourth most common cancer among women.
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