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Articles by Werner Held
The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer - Nature
Abstract Current cancer immunotherapy predominately focuses on eliciting type 1 immune responses fighting cancer; however, long-term complete remission remains uncommon1,2. A pivotal question arises as to whether type 2 immunity can be orchestrated alongside type 1-centric immunotherapy to achieve enduring response against cancer3,4.
Easy way to restore deleted variable collections
5 Hi there, we have the same issue here. Also restoring via file history does not work. Strange thing is, that we cannot even restore variable collection from open branches (so keeping the color-variables that are still in the branch)… while updating from master, Figma is removing the variables in the branch, too, although we defined “keep from branch” … I’ve also reached out to support, but unfortunately haven’t got a reply yet.
Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion - Nature Immunology
Abstract Persistent exposure to antigen during chronic infection or cancer renders T cells dysfunctional. The molecular mechanisms regulating this state of exhaustion are thought to be common in infection and cancer, despite obvious differences in their microenvironments.
Stem-cell-like T cells have a specific entry gate to the tumor
Tumor-infiltrated T cells with stem-cell-like properties are important for determining the immunotherapy response. In this issue of Cancer Cell, Asrir and colleagues show that their entry requires specialized tumor-associated endothelial cells that resemble immature and inflamed lymph node vessels and that immunotherapy enhances the recruitment capacity of these endothelial cells.
PD-1+ Tcf1+ CD8+ T cells from established chronic infection can form memory while retaining a stable imprint of persistent antigen exposure
(Cell Reports 36, 109672-1–109672-14.e1–e4; September 7, 2021) In the originally published version of this article, the title contained a typo, where “stable imprint” was inadvertently changed to one word during the production process. The title has now been corrected online. The production team regrets this error. Article Info Identification DOI: https://doi.org/10.1016/j.celrep.2021.110010 Copyright © 2021 The Author(s).
Not All Tumor-Infiltrating CD8+ T Cells Are Created Equal
Adoptive cell immunotherapy using in vitro expanded autologous tumor-infiltrating lymphocytes has the potential to mediate durable remission of certain types of cancer. A recent paper in Science shows that complete and durable control of metastatic melanoma requires the infusion of tumor-specific CD8 + T cells that have stem-cell-like properties.
Harnessing Stem Cell–Like T Cells to Better Fight Cancer | RealClearScience
Harnessing Stem Cell–Like T Cells to Better Fight Cancer Tumors are relatively easy to treat if they stay put, but cancer cells become more deadly when they disseminate to distant parts of the body. Read Full Article »
Intratumoral CD8+ T cells with stem cell-like properties: Implications for cancer immunotherapy
Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.
Defining ‘T cell exhaustion’ - Nature Reviews Immunology
Abstract ‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumours. Understanding the features of and pathways to exhaustion has crucial implications for the success of checkpoint blockade and adoptive T cell transfer therapies.
Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. PreviewFeeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells © 2017 Elsevier Inc.
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