Wondong Kim on Muck Rack

Wondong Kim

As seen in: Cell Press
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Articles

Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney

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By Petra Simic, Wondong Kim, Wen Zhou, Kerry A. Pierce
| The Journal of Clinical Investigation
Research ArticleBone biologyNephrology Free access | 10.1172/JCI131190 Petra Simic,1,2 Wondong Kim,1,2 Wen Zhou,1,2 Kerry A. Pierce,3 Wenhan Chang,4 David B. Sykes,5 Najihah B. Aziz,5 Sammy Elmariah,6 Debby Ngo,7 Paola Divieti Pajevic,8 Nicolas Govea,2 Bryan R. Kestenbaum,9 Ian H. de Boer,9 Zhiqiang Cheng,4 Marta Christov,10 Jerold Chun,11 David E. Leaf,12 Sushrut S. Waikar,13 Andrew M. Tager,14 Robert E. Gerszten,3,7 Ravi I. Thadhani,1 Clary B. Clish,3 Harald Jüppner,2,15 Marc N. Wein,2 and Eugene P.
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Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD+ Recycling

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By Wondong Kim, Amy Deik, Metabolite Profiling, Clicerio Gonzalez
| Cell Press Verified
Highlights • Blocking ETC or lactate production reduces cytosolic NAD +/NADH and increases HUFAs • HUFA synthesis by D5D and D6D is a mechanism for glycolytic NAD + recycling • D5D- and D6D-mediated NAD + regeneration can be acutely adaptive in vivo • SLC16A11 and FADS1-3 may influence metabolic risk via impact on cytosolic NAD +/NADH Summary The reactions catalyzed by the delta-5 and delta-6 desaturases (D5D/D6D), key enzymes responsible for highly unsaturated fatty acid (HUFA) synthesis,...
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