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Articles by Wu Sun
Integrated transcriptomics identifies a high-glycolysis osteosarcoma phenotype and links SSR3 to stemness and chemoresistance
Abstract Osteosarcoma treatment is hampered by intratumoral metabolic heterogeneity. We analyzed single‑cell and spatial transcriptomic data from 27 patients and stratified malignant cells into high- (HGlyOS), medium-, and low-glycolysis groups. HGlyOS cells exhibited enhanced stemness and chemotherapy resistance features and occupied an early inferred transcriptional state.
Early Nrf2/HO-1 signaling activation following surgical decompression in a rat model of lumbar spinal stenosis-induced neurogenic intermittent claudication
Abstract Lumbar spinal stenosis is a prevalent degenerative disease globally. The hallmark symptom is neurogenic intermittent claudication, characterized by lower extremity pain during walking that is relieved by resting.Although mechanical constriction initiates the primary pathology, the precise molecular orchestration underlying this transient, rest-induced symptomatic resolution has not yet been fully characterized.
BMPR1B c.746A>G (p.Gln249Arg) polymorphism is associated with litter size in Tibetan Plateau sheep
Abstract The BMPR1B (FecB) c.746A>G (p.Gln249Arg) variant is a major fecundity locus in sheep, but its distribution and association with litter size require population-specific evaluation. We analysed archived genotype and reproductive records from 120 Tibetan Plateau ewes sampled from four flocks in Qinghai Province, China. Genotypes were assigned by PCR-RFLP, and three archived TIFF export panels labelled AA, AG and GG were retained.
Stress homogenization enabled by a layered composite electrolyte for high-performance all-solid-state lithium metal batteries
Abstract The growing demand for high-energy-density and high-safety batteries has spurred research interest in all-solid-state lithium metal batteries. As the core constituent, solid polymer electrolytes exhibit improved interfacial compatibility compared with their inorganic counterparts. However, their further applications are impeded by suboptimal ionic conductivity and stress-induced uncontrolled Li deposition.
Precipitation-mediated asymmetric fitness consequences of nectar robbing in distylous Primula florindae
1 INTRODUCTION Climate plays a pivotal role in shaping plant diversity by impacting plant reproductive success (Basnett et al., 2025; Borghi et al., 2019; Buonaiuto, 2024; Collins et al., 2025; Waser & Price, 2016).
Acute hypersensitivity reactions to paclitaxel polymeric micelles during malignant tumor treatment: a retrospective real-world study
Abstract Background and aims: Paclitaxel polymeric micelles (pm-Pac) are widely used for solid tumors, but real-world data on acute hypersensitivity reactions (HSRs) are limited. This exploratory study aimed to characterize the clinical features, risk factors, and dynamic laboratory changes in pm-Pac-associated acute HSRs. Methods: This retrospective study included 220 patients treated with pm-Pac from March 2023 to April 2026. Clinical data were extracted from electronic medical records.
Reply to: The size of tropical vegetation gross primary production
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replying to: Tian, J. et al. Nature https://doi.org/10.1038/s41586-026-10562-z (2026). In their Comment, Tian et al.1 argue that we overestimated tropical gross primary productivity (GPP)2. Here we address their concerns and demonstrate that the conclusions of our Article2 remain fully supported.
By Jiameng Lai, Wu Sun, Danica Lombardozzi, J. Campbell Verified, Lianhong Gu, Yiqi Luo, Le Kuai, Ying Sun, Linda M. J. Kooijmans
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Nature
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Human Breast Milk-Derived Lactiplantibacillus plantarum WLPL04 as a Functional Probiotic for Preventing Staphylococcus aureus -Induced in Periparturient Mice
1 Introduction Mastitis, one of the most serious diseases affecting the dairy industry, is closely associated with microbial homeostasis in its pathogenesis (Zhao et al. 2025). In humans, it affects 3%–33% of lactating women (Zanvit et al. 2015), often leading to premature cessation of breastfeeding and increased healthcare costs (Dener and Inan 2003; Gianni et al. 2019). In dairy animals, mastitis results in substantial economic losses due to reduced milk production and compromised milk quality.
Global variation in vegetation carbon use efficiency inferred from eddy covariance observations - Nature Ecology & Evolution
Abstract Terrestrial ecosystems have been serving as a strong carbon sink that offsets one-quarter of anthropogenic CO2 emissions. Carbon use efficiency (CUE), the percentage of photosynthesized carbon that is available for biomass production and other secondary carbon products, is one factor determining the carbon sink size.
Construction of clay-mediated nZVI composites to alleviate the decline in Cr(VI) removal during co-transport with humic acid and phosphate
Construction of clay-mediated nZVI composites to alleviate the decline in Cr(VI) removal during co-transport with humic acid and phosphate The natural presence of phosphate and humic acid (HA) may impact the removal of Cr(VI) by green synthesized clay-supported nano-zero-valent iron (nZVI@GT) composites. It triggers the investigation of Cr speciation transformation by M-nZVI@GT and K-nZVI@GT, prepared through nZVI@GT loaded on montmorillonite and kaolinite clays.
Elevated KIF2C Expression Drives Osteosarcoma Progression by Modulating the Wnt/β‐Catenin Signaling Pathway and Contributing to an Immunosuppressive Tumor Microenvironment
AUC area under the curve; CI, Confidence interval DEGs differentially expressed genes GEO Gene Expression Omnibus GSVA Gene set variation analysis KEGG Kyoto Encyclopedia of Genes and Genomes KIF2C Kinesin family member 2C OS osteosarcoma RGs related genes ROC receiver operating characteristic SMD standardized mean difference sROC summarized receiver operating characteristic TARGET Therapeutically Applicable Research To Generate Effective Treatments TCGA The Cancer Genome Atlas database 1...
Heterogeneous Engineered Solid Electrolyte for Seamless and Stable Integration of Anode and Cathode
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202501870-sup-0001-SuppMat.pdf3.1 MB Supporting Information References 1a) , , , , , , Chem. Soc. Rev. 2020, 49, 2701; b) , , , , , , , , , , , Energy Mater. Adv. 2021, 2021, 1205324; c) , , , , , , , eScience 2022, 2, 138; d) , , , , Chem. Bio. Engin. 2024, 1, 737; e) , , , , , , , , , , , , , , , , , , , Angew. Chem. Int. Ed. Engl. 2024, 63, 202404816.
Multiscale Engineered Bionic Solid‐State Electrolytes Breaking the Stiffness‐Damping Trade‐Off
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Terrestrial photosynthesis inferred from plant carbonyl sulfide uptake - Nature
Abstract Terrestrial photosynthesis, or gross primary production (GPP), is the largest carbon flux in the biosphere, but its global magnitude and spatiotemporal dynamics remain uncertain1. The global annual mean GPP is historically thought to be around 120 PgC yr−1 (refs. 2,3,4,5,6), which is about 30–50 PgC yr−1 lower than GPP inferred from the oxygen-18 (18O) isotope7 and soil respiration8. This disparity is a source of uncertainty in predicting climate–carbon cycle feedbacks9,10.
MFAM-AD: an anomaly detection model for multivariate time series using attention mechanism to fuse multi-scale features
Anomaly detection plays an important role in improving data accuracy, identifying potential threats, enhancing security protection capabilities, and achieving widespread applicability. Kong et al. (2024) identifies abnormal patterns or trajectories in urban environments by detecting abnormal movements of cars and providing timely warnings to drivers to avoid accidents, highlighting the importance of anomaly detection.
Inside Cover: Amorphous FeSnOx Nanosheets with Hierarchical Vacancies for Room‐Temperature Sodium‐Sulfur Batteries (Angew. Chem. Int. Ed. 38/2024)
Wu Sun State Key Laboratory of Molecular Engineering of Polymers, Department of Materials Science, Fudan University, Shanghai, 200438 P. R. China These authors contributed equally to this work. Search for more papers by this author
An anomaly detection model for multivariate time series with anomaly perception
In real-world scenarios, multiple sensors or agents continuously collect data from various system components for real-time monitoring (Kim et al., 2023). These sensors will generate a large amount of interrelated time series data. For example, in IT systems, performance monitoring software simultaneously gathers metrics like CPU utilization, memory usage, and user visits, among others, and stores them in a time series database. These metrics often exhibit complex correlations.
Horticulturae | Free Full-Text | Transcriptomic Analyses Reveal the Mechanism by Which Different Light Qualities and Light Duration Induce Anthocyanin Biosynthesis in ‘Kyoho’ Grapes
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Multiple self-mixing interference with the Faraday effect for detecting magnetic fields
Detection of magnetic fields is widely used in magnetic materials, electronic devices, medical imaging, and navigation systems. We conducted the experiments using a TGG crystal in different magnetic fields to observe multiple laser self-mixing interference in the frequency domain for experimentation.
Identifying Meat from Grazing or Feedlot Yaks Using Visible and Near-infrared Spectroscopy with Chemometrics
Article Dans Une Revue Journal of Food Protection Année : 2024 Identifying Meat from Grazing or Feedlot Yaks Using Visible and Near-infrared Spectroscopy with Chemometrics Mots clés Farming system Partial least squares discriminant analysis (PLS-DA) Product traceability Quality of yak meat Soft independent modeling of class analogies (SIMCA) Domaines Sciences de l'environnement Alimentation et Nutrition Médecine vétérinaire et santé animale Sciences et techniques de l'agriculture Fichier...
Amorphous FeSnOx Nanosheets with Hierarchical Vacancies for Room‐Temperature Sodium‐Sulfur Batteries
Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Restricted internal diffusion weakens transpiration-photosynthesis coupling during heatwaves: Evidence from leaf carbonyl sulphide exchange
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description pce14840-sup-0001-supporting-information.pdf5.1 MB Supplementary information. REFERENCES , , , , , et al. (2009) Temperature sensitivity of drought-induced tree mortality portends increased regional die-off under global-change-type drought. Proceedings of the National Academy of Sciences, 106(17), 7063–7066.
Equivalent radius of atmosphere aerosol in haze weather based on laser scattering
The investigation of atmospheric aerosols holds paramount importance within the environmental realm. This significance arises from the intricate nature of aerosol distribution and size in real-life hazy weather conditions. In this work, we have employed the equivalent radius of the aerosols in haze weather obtained from the volume spectrum, and then the scattering characteristics of these aerosols are obtained using the equivalent radius.
Dynamic Tensile Failure Characteristics and Energy Dissipation of Red Sandstone under Dry-Wet Cycles
Abstract : Studying the dynamic properties of rocks in complex environments is of great significance to the sustainable development of deep-sea metal mineral resource extraction. To investigate the influence of dry–wet cycles on the dynamic tensile properties and energy dissipation of red sandstone, a series of dynamic Brazilian disc tests was carried out through the split Hopkinson pressure bar (SHPB) apparatus.
Biome-scale temperature sensitivity of ecosystem respiration revealed by atmospheric CO2 observations - Nature Ecology & Evolution
Abstract The temperature sensitivity of ecosystem respiration regulates how the terrestrial carbon sink responds to a warming climate but has been difficult to constrain observationally beyond the plot scale.
Analysis of the pachychoroid phenotype in an Asian population: methodology and baseline study population characteristics
http://orcid.org/0000-0002-4514-250XWendy Meihua Wong1, http://orcid.org/0000-0002-1638-9861Wu Sun2, Chinmayi Vyas2, Angie Hon Chi Fong3, Caroline K Chee1, Xin Yi Su1, Kelvin YC Teo2,4,5, http://orcid.org/0000-0003-3358-3516Chui Ming Gemmy Cheung2,4,5 1 Ophthalmology, National University Hospital, Singapore 2 Retina Research Group, Singapore Eye Research Institute, Singapore 3 Ophthalmology, Hong Kong Eye Hospital, Hong Kong, Hong Kong 4 Medical Retina, Singapore National Eye Centre,...
A Novel Method for Detecting Fe2+ at a Micromolar Concentration Based on Multiple Self-Mixing Interference Using a Fiber Laser
Open AccessCommunication by Wu Sun *, Zhuo Yang , Guo Feng , Zhou Chen , Qiaoyun Chang , Lan Hai and Zeqing Guo Key Laboratory of Functional Materials and Devices for Informatics of Anhui Educational Institutions, Fuyang Normal University, Fuyang 236037, China * Author to whom correspondence should be addressed.
Analysis of the pachychoroid phenotype in an Asian population: methodology and baseline study population characteristics
http://orcid.org/0000-0002-4514-250XWendy Meihua Wong1, http://orcid.org/0000-0002-1638-9861Wu Sun2, Chinmayi Vyas2, Angie Hon Chi Fong3, Caroline K Chee1, Xin Yi Su1, Kelvin YC Teo2,4,5, http://orcid.org/0000-0003-3358-3516Chui Ming Gemmy Cheung2,4,5 1Ophthalmology, National University Hospital, Singapore 2Retina Research Group, Singapore Eye Research Institute, Singapore 3Ophthalmology, Hong Kong Eye Hospital, Hong Kong, Hong Kong 4Medical Retina, Singapore National Eye Centre, Singapore...
Soil Compaction and Maize Root Distribution under Subsoiling Tillage in a Wheat–Maize Double Cropping System
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Increasing sensitivity of dryland vegetation greenness to precipitation due to rising atmospheric CO2 - Nature Communications
Abstract Water availability plays a critical role in shaping terrestrial ecosystems, particularly in low- and mid-latitude regions. The sensitivity of vegetation growth to precipitation strongly regulates global vegetation dynamics and their responses to drought, yet sensitivity changes in response to climate change remain poorly understood.
Epidemiology and risk factors of scrub typhus in Taiwan: A nationwide database study from 1996 to 2014
ORIGINAL ARTICLE Yi-Chin Chang, orcid.org/0000-0002-0078-2052 Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan Search for more papers by this author Wu Sun, Infection Control Department, Pao-Chien Hospital, Pingtung County, Taiwan Search for more papers by this author Jiun-Nong Lin, orcid.org/0000-0002-4417-5350 Division of Infectious Diseases, Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan...
The epidemiology, characteristics and outbreaks of human leptospirosis and the association with animals in Taiwan, 2007-2014: A nationwide database study - Tsai - 2020 - Zoonoses and Public Health - Wiley Online Library
ORIGINAL ARTICLE Chia‐Ta Tsai Division of Infectious Diseases, Department of Internal Medicine, E‐Da Hospital, I‐Shou University, Kaohsiung, Taiwan Department of Infection Control, E‐Da Hospital, I‐Shou University, Kaohsiung, Taiwan Search for more papers by this author Jiun‐Nong Lin Division of Infectious Diseases, Department of Internal Medicine, E‐Da Hospital, I‐Shou University, Kaohsiung, Taiwan School of Medicine, College of Medicine, I‐Shou University, Kaohsiung, Taiwan Department of...
The epidemiology, characteristics and outbreaks of human leptospirosis and the association with animals in Taiwan, 2007-2014: A nationwide database study - Tsai - - Zoonoses and Public Health - Wiley Online Library
ORIGINAL ARTICLE Chia‐Ta Tsai Division of Infectious Diseases, Department of Internal Medicine, E‐Da Hospital, I‐Shou University, Kaohsiung, Taiwan Department of Infection Control, E‐Da Hospital, I‐Shou University, Kaohsiung, Taiwan Search for more papers by this author Jiun‐Nong Lin Division of Infectious Diseases, Department of Internal Medicine, E‐Da Hospital, I‐Shou University, Kaohsiung, Taiwan School of Medicine, College of Medicine, I‐Shou University, Kaohsiung, Taiwan Department of...
Deregulation of the miR-16-KRAS axis promotes colorectal cancer
We first determined the expression patterns of the KRAS protein in human CRC tissues. We found that the KRAS protein expression levels were significantly higher in the CRC tissues than in the normal adjacent tissue (NAT) samples (Fig. 1A and B). The mean expression levels of KRAS protein in the CRC and NAT samples are shown in Supplementary Fig. 1A.
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