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Articles by Xia Guo
Association between household coal use duration and upper gastrointestinal cancer and precancerous lesions: a cross-sectional study
Abstract Background: To explore the association between household coal use duration and upper gastrointestinal cancer and precancerous lesions. Methods: This study is a cross-sectional study. The research subjects were selected from those in Lucheng District and Pingshun County of Shanxi Province who participated in the upper gastrointestinal cancer screening and had complete data.
Association between METS-VF and hypertension in U.S.: a cross-sectional analysis of NHANES data
Abstract Visceral fat accumulation is a key factor in the onset of cardiometabolic diseases, including hypertension. Metabolic Score for Visceral Fat (METS-VF) is an innovative, non-invasive metric developed to estimate visceral fat based on commonly accessible clinical parameters. A total of 13,822 participants were included in this cross-sectional analysis. METS-VF was calculated using a validated formula incorporating age, sex, metabolic score for insulin resistance, waist-to-height ratio.
Management of persistent soft tissue residuals exhibiting an imaging paradox (^123I-MIBG-negative/^68Ga-DOTA-NOC-positive) in high-risk neuroblastoma following immunotherapy: a case report
Abstract Managing persistent soft tissue residual disease in high-risk neuroblastoma (HR-NB) remains a clinical challenge, particularly when conventional response assessments suggest remission but residual lesions persist. Determining whether such lesions represent inactive treatment-related changes or viable tumor has important implications for subsequent management.
Case Report: DICER1 mutation-associated anaplastic sarcoma of the kidney in a child
Abstract DICER1 syndrome is a hereditary tumor predisposition syndrome caused by pathogenic germline variants in DICER1 and is characterized by multi-organ susceptibility; sarcomas remain uncommon within this spectrum. We report a 2-year-old girl with anaplastic sarcoma of the kidney (ASK). Molecular testing identified a germline DICER1 c.3300dupA frameshift variant (p.S1101Ifs*3), inherited from her father, and a tumor-associated c.5125G>A missense variant (p.D1709N).
Clinical heterogeneity of Pisa syndrome across Lewy body disorders: a multicenter comparison of Parkinson’s disease and dementia with Lewy bodies
Abstract Background: Pisa syndrome (PS) is well recognized in Parkinson’s disease (PD) but has been less studied in dementia with Lewy bodies (DLB), and direct comparisons are scarce. The aim of this study is to compare the clinical expression of PS across PD and DLB. Methods: In this multicenter cross-sectional study, patients were classified as PD without PS (n = 50), PD with PS (n = 41), DLB without PS (n = 45), or DLB with PS (n = 35).
Exogenous Epstein–Barr virus nuclear antigen 1 induces ADAR1-driven tumor resistance against immunotherapy - Signal Transduction and Targeted Therapy
Abstract Immune checkpoint blockade (ICB) therapy continues to face limitations due to tumor resistance linked to suppressed interferon (IFN) signaling. This suppression can be attributed to multiple mechanisms, among which viral pathogens represent a compelling though not yet fully elucidated factor. Here, we demonstrate that exogenous Epstein–Barr virus-encoded EBNA1 drives immunosuppression via enhanced RNA-editing enzyme ADAR1-mediated RNA editing.
The fragile equilibrium of cancer latency: lessons from spontaneous remission in congenital leukemia - Leukemia
We read with interest the insightful perspective by Abecasis et al. on cancer latency [1]. The authors pointed out that, as our understanding of cancer evolution grows, defining latency solely as the time from an initiating event to clinical diagnosis is increasingly insufficient.
Dissecting neuroblastoma heterogeneity through single-cell multi-omics: insights into development, immunity, and therapeutic resistance - Oncogene
Abstract Neuroblastoma (NB), the most common extracranial solid tumor in children, is characterized by remarkable cellular heterogeneity and clinical variability ranging from spontaneous regression to aggressive progression and relapse. Despite advances in multimodal therapies, including surgery, chemotherapy, radiotherapy, differentiation therapy, and immunotherapy—treatment resistance remains the principal barrier to improving survival in high-risk patients.
Association of white matter hyperintensity with systemic inflammation markers and cognitive assessments: a cross-sectional study via SHAP analysis
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ORIGINAL RESEARCH article Volume 17 - 2025 | https://doi.org/10.3389/fnagi.2025.1667025 1 Introduction White matter hyperintensity (WMH) is a significant neuroimaging marker on brain magnetic resonance imaging (MRI), appearing as characteristic hyperintensities on T2-weighted and fluid-attenuated inversion recovery (FLAIR) sequences. Its underlying pathology includes demyelination, axonal degeneration, and gliosis (Karvelas and Elahi, 2023).
By Jiayu Lv, Xinhui Li, Wenlong Yu, Lu Wang Verified, Hua Li, Shuaiqiang Zhang, Zi Ao Guo, Yiming Liu, Xia Guo, Lie Wu, Dewang Gao, Wen Yong, Shangjia Ma, Zhipeng Ju
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Frontiers
Direct Sequencing of DNA 5-Methylcytosine by Engineered Dioxygenase NTET-assisted eNAPS
Direct Sequencing of DNA 5-Methylcytosine by Engineered Dioxygenase NTET-assisted eNAPS DNA methylation (5-methylcytosine, 5mC) represents the most prevalent modification in mammals, which is closely linked to disease pathogenesis and cancer development. Single-base resolution sequencing and quantitative analysis of 5mC are essential for elucidating its biological functions. However, current methods are still limited by resolution, sequencing bias, and false positives.
Robust Graphene Oxide Composite Films via Covalent Cross-linking and Applicable to Solar Water Evaporators
Robust Graphene Oxide Composite Films via Covalent Cross-linking and Applicable to Solar Water Evaporators Hydrophilic graphene oxide (GO) films have been extensively researched in the fields of water purification such as oil-water separation and seawater desalination. However, the GO films always possess inferior mechanical performance since the structural defects leading from oxidation.
Direct Single-Nucleotide Resolution Sequencing of DNA 5-Methylcytosine Using Engineered DNA Methyltransferase-Mediated CMD-seq
Direct Single-Nucleotide Resolution Sequencing of DNA 5-Methylcytosine Using Engineered DNA Methyltransferase-Mediated CMD-seq 5-Methylcytosine (5mC) is a crucial epigenetic modification in the mammalian genome, primarily occurring at CG dinucleotides. Accurate localization of 5mC is essential for understanding its functional significance. In this study, we discovered a novel DNA methyltransferase, designated M.MedI, from the bacterium Mycoplasmopsis edwardii.
Deaminase-Driven Random Mutation Enables Efficient DNA Mutagenesis for Protein Evolution
Deaminase-Driven Random Mutation Enables Efficient DNA Mutagenesis for Protein Evolution Protein evolution has emerged as a crucial tool for generating proteins with novel characteristics. A key step in protein evolution is the mutagenesis of protein-coding DNA. Error-prone PCR (epPCR) is a frequently used technique, but its low mutation efficiency often requires multiple rounds of mutagenesis, which can be time-consuming.
A Simulation-Optimization Approach of Geothermal Well-Doublet Placement in North China Using Back Propagation Neural Network and Genetic Algorithm
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Orthologous Mammalian A3A-Mediated Single-Nucleotide Resolution Sequencing of DNA Epigenetic Modification 5-Hydroxymethylcytosine
Orthologous Mammalian A3A-Mediated Single-Nucleotide Resolution Sequencing of DNA Epigenetic Modification 5-Hydroxymethylcytosine Epigenetic modifications in genomes play a crucial role in regulating gene expression in mammals. Among these modifications, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are recognized as the fifth and sixth nucleobases in genomes, respectively, and are the two most significant epigenetic marks in mammals.
Temozolomide‐Promoted MGMT Transcription Contributes to Chemoresistance by Activating the ERK Signalling Pathway in Malignant Melanoma
1 Introduction Malignant melanoma results from the malignant transformation of melanocytes, which are of neural crest origin [1-3]. Melanoma mostly occurs in the skin, but can also be seen in mucous membranes and internal organs. Melanoma at early stages can be cured by the surgical resection of the primary lesion. Advanced melanomas undergo systemic therapy, which includes chemotherapy, targeted therapy and immunotherapy.
Targeting the STAT3 pathway with STAT3 degraders
Highlights Signal transducer and activator of transcription 3 (STAT3), as an important transcription factor, is frequently aberrantly activated in multiple tumor types. STAT3 has been widely identified as a therapeutic target for various diseases, especially tumors. A variety of STAT3 inhibitors have been disclosed, while their development is seriously hindered by numerous dilemmas. Targeted protein degradation strategies have trigged a new revolution for drug development.
Simultaneous Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine at Specific Genomic Loci by Engineered Deaminase-Assisted Sequencing
Simultaneous Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine at Specific Genomic Loci by Engineered Deaminase-Assisted Sequencing Cytosine modifications, particularly 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), play crucial roles in numerous biological processes. Current analytical methods are often constrained to the separate detection of either 5mC or 5hmC, or the combination of both modifications.
Non‐Fully Conjugated Photovoltaic Materials with Y‐Series Acceptor Backbone for High‐Performance Organic Solar Cells†
References 1 ; ; ; ; ; ; ; ; ; ; A Simple Nonfused Ring Electron Acceptor with a Power Conversion Efficiency Over 16%. Chin. J. Chem. 2023, 41, 665–671. 2 ; ; ; ; ; ; ; ; Synergetic alkoxy side-chain and chlorine-contained end group strategy toward high performance ultra-narrow bandgap small molecule acceptors. Chin. J. Chem. 2023, 41, 2664–2670. 3 ; ; ; ; ; ; ; ; ; Regioregular Non-Fused Polymerized Small Molecular Acceptors Enabling Efficient All-Polymer Solar Cells. Chin. J. Chem. 2023, 41, 790–796.
Reducing PD-L1 Expression by Degraders and Downregulators as a Novel Strategy to Target the PD-1/PD-L1 Pathway
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Reducing PD-L1 Expression by Degraders and Downregulators as a Novel Strategy to Target the PD-1/PD-L1 Pathway
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Med. Chem. 2024, XXXX, XXX This article has not yet been cited by other publications.
Eugenol reduces the proliferation and migration of HVSMCs
Back to Journals » Journal of Inflammation Research » Volume 17 Authors He JH, Li XJ, Wang SP, Guo X, Chu HX, Xu HC, Wang YS Received 27 October 2023 Accepted for publication 20 January 2024 Published 2 February 2024 Volume 2024:17 Pages 641—653 DOI https://doi.org/10.2147/JIR.S446960 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Adam D Bachstetter Jia-Huan He,1,* Xiang-Jun Li,2,* Shi-Peng Wang,1 Xia...
Ecological environment value assessment and ecological civilization in the Changjiang River basin
REFERENCES , , & (2017) Remotely-sensed early warning signals of a critical transition in a wetland ecosystem. Remote Sensing, 9(4), 352. Available from: https://doi.org/10.3390/rs9040352 , & (2012) Application of artificial neural network to predict TDS in Talkheh Rud River. Journal of Irrigation and Drainage Engineering, 138(4), 363–370.
AlkB-Facilitated Demethylation Enables Quantitative and Site-Specific Detection of Dual Methylation of Adenosine in RNA
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AlkB-Facilitated Demethylation Enables Quantitative and Site-Specific Detection of Dual Methylation of Adenosine in RNA
RNA molecules undergo various chemical modifications that play critical roles in a wide range of biological processes. N6,N6-Dimethyladenosine (m6,6A) is a conserved RNA modification and is essential for the processing of rRNA. To gain a deeper understanding of the functions of m6,6A, site-specific and accurate quantification of this modification in RNA is indispensable.
Fine-Tuned Active Layer Morphology for Bulk Heterojunction Organic Solar Cells with Indene-C60 Bisadduct as a Third Component
RETURN TO ARTICLES ASAPPREVOrganic Electronic D...Organic Electronic DevicesNEXT * Bing Guo MOE Key Laboratory of Low-grade Energy Utilization Technologies and Systems, School of Energy & Power Engineering, Chongqing University, Chongqing 400044, China *Email: bing.guo@cqu.edu.cn , Wanbin Li Laboratory of Advanced Optoelectronic Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China , * Xia Guo Laboratory of Advanced...
BRD4 as a Therapeutic Target in Pulmonary Diseases
1. Introduction The bromodomain and extra-terminal domain (BET) family are known as epigenetic readers to regulate gene transcription. It has four members in mammals, i.e., bromodomain-containing protein 2, 3, 4 (BRD2, BRD3, and BRD4) and testis-specific BRDT. BET proteins have several conserved domains. All BET members share two tandem N-terminal bromodomains (BDs) and one C-terminal extra-terminal (ET) domain.
π‐Extended End Groups Enable High‐Performance All‐Polymer Solar Cells with Near‐Infrared Absorption
Report This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/cjoc.202300299. Comprehensive Summary Narrow-bandgap n-type polymers are essential for advancing the development of all-polymer solar cells (all-PSCs).
Cooperative membership and new technology adoption of family farms: Evidence from China
Abstract Various policies have been implemented to encourage the development of family farms and cooperatives in the past decade in China. New technology adoption is a crucial part in promoting the performance of family farms. However, empirical evidence on whether and how cooperatives would facilitate family farms to adopt new technologies remains unclear.
Improvement of p-sulfonatocalix[4]arene on the performance of PEG/salt aqueous two-phase system
Improvement of p-sulfonatocalix[4]arene on the performance of PEG/salt aqueous two-phase system Yanrong Cheng, Wenlin Xu, Yaqiong Wang and Xia Guo Abstract The PEG/salt aqueous two-phase system (ATPS) is the most common ATPS, but its application is still limited due to restricted polarity difference between the two phases and the poor enhancement effect of adjuvants on ATPS performance so far.
Efficient Polymer Acceptor with Fluorinated Linkers Enables All Polymer Solar Cells with Efficiency of 15.7%
Efficient Polymer Acceptor with Fluorinated Linkers Enables All Polymer Solar Cells with Efficiency of 15.7% Haiqin Xiao, Junfang Lv, Miao Liu, Xia Guo, Xinxin Xia, Xinhui Lu and Maojie Zhang Abstract Despite the significant progress of all-polymer solar cells (all-PSCs) in recent years, obtaining both high open-circuit voltage (VOC) and short-circuit current density (JSC) simultaneously has been a challenging issue.
Costs of Dementia with Lewy Bodies: A Chinese multicenter cross‐sectional study
Abstract Introduction Dementia with Lewy bodies (DLB) significantly increases the economic burden on caregivers and society, but few studies have focused on the costs. This study aims to evaluate the current economic costs of DLB and its related factors. Methods A total of 193 patients diagnosed with probable DLB were consecutively enrolled from 6 memory clinics between August 2017 to July 2021.
High-Performance Semitransparent Organic Solar Cells Enabled by Pseudo-Planar Heterojunction Structures Combined with Optical Engineering
High-Performance Semitransparent Organic Solar Cells Enabled by Pseudo-Planar Heterojunction Structures Combined with Optical Engineering Ding Yang, Rui Zhang, Yu Shi, Xia Guo and Maojie Zhang Abstract Semitransparent organic solar cells (ST-OSCs) are emerging as a promising renewable energy technology for building integration.
A novel A-DA’D-A bifunctional small molecule for organic solar cells application with impressive photovoltaic performance
A novel A-DA’D-A bifunctional small molecule for organic solar cells application with impressive photovoltaic performance Junfang Lv, Yuhao Chen, Xia Guo, Jinjing Qiu, Zhiliang Zhang, Jianqiu Wang, Haiyan Liang, Liu Zhang, Lei Zhu, Feng Liu and Maojie Zhang Abstract In organic solar cells (OSCs), the vast majority of photovoltaic materials are concentrated in unipolar materials, but the bifunctional small molecule materials that can work as the donors and acceptors, have rarely been studied...
15.8% Efficiency All-Small-Molecule Solar Cells Enabled by a Combination of Side-chain Engineering and Polymer Additive
15.8% Efficiency All-Small-Molecule Solar Cells Enabled by a Combination of Side-chain Engineering and Polymer Additive Haiyan Liang, Yang Wang, Xia Guo, Ding Yang, Xinxin Xia, Jianqiu Wang, Liu Zhang, Yu Shi, Xinhui Lu and Maojie Zhang Abstract All-small-molecule OSCs (ASM-OSCs) are more suitable for commercial-scale manufacturing owing to the merits of small molecules, such as well-defined chemical molecular structures, easy synthesis, as well as less batch-to-batch variation.
Phototactic Micromotor Assemblies in Dynamic Line Formations for Wide-Range Micromanipulations
Phototactic Micromotor Assemblies in Dynamic Line Formations for Wide-Range Micromanipulations In nature, living organisms can perform powerful cooperation by assembling themselves into defined formations. Enlightened by this, we herein demonstrate phototactic micromotor assemblies flocking in dynamic line formations for manipulating large cargoes in a wide range.
J‐Aggregation‐Driven Supramolecular Assembly of Dye‐Conjugated Block Polymers: From Morphological Tailoring to Anticancer Applications
Research Article Shuoxin Li, Shuoxin Li State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Key Laboratory of Functional Polymer Materials of Ministry of Education, Nankai University, Tianjin, 300071 P. R. China Search for more papers by this author Xiaosa Yan, Xiaosa Yan State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Key Laboratory of Functional Polymer Materials of Ministry of Education, Nankai University, Tianjin, 300071 P. R.
New Electron Acceptor with End-Extended Conjugation for High-Performance Polymer Solar Cells
To develop high-efficiency polymer solar cells (PSCs), the acceptors in a bulk heterojunction (BHJ) blend are supposed to possess complementary absorption bands in the near-infrared region and a suitable energy level to be well-matched with the donors. In this work, a new small molecular acceptor (SMA) named IDTT8-N based on an indacenodithienothiophene (IDTT) core was designed and synthesized.
A bimetallic nanocatalyst for light-free oxygen sensitization therapy
Highlights • An autocatalytic bimetallic nanocatalyst for 1O2 generation is synthesized • Strain and electronic effects are induced for highly efficient 1O2 generation • The nanocatalyst realizes high-performance, light-free oxygen sensitization therapy Summary Singlet oxygen (1O2) is extensively employed by reactive oxygen species (ROS)-based cancer therapies, such as photodynamic therapy (PDT) and chemodynamic therapy (CDT).
Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics
Abstract Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer patients receiving chemotherapy. It is correlated with the collateral damage to renal cells caused by reactive oxygen species (ROS). Currently, ROS management is a practical strategy that can reduce the risk of chemotherapy-related AKI, but at the cost of chemotherapeutic efficacy.
Small Molecule Acceptor with Heptacyclic Benzodi(thienocyclopentafuran) Central Unit Achieving a 13.4% Efficiency in Polymer Solar Cells with Low Energy Loss
Small Molecule Acceptor with Heptacyclic Benzodi(thienocyclopentafuran) Central Unit Achieving a 13.4% Efficiency in Polymer Solar Cells with Low Energy Loss Optimizing the molecular backbone is the most important strategies to improve the photovoltaic performance of Acceptor-Donor-Acceptor type small molecule acceptor (SMA) materials.
Optimized Active Layer Morphologies via Ternary Copolymerization of Polymer Donors for 17.6 % Efficiency Organic Solar cells with Enhanced Fill Factor - Guo - - Angewandte Chemie International Edition - Wiley Online Library
Research Article Prof. Long Ye Corresponding Author yelong@tju.edu.cn School of Materials Science and Engineering, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Tianjin University, Tianjin, 300350 China Search for more papers by this author Prof.
Color-neutral, semitransparent organic photovoltaics for power window applications
By letting students experiment in the kitchen rather than the lab, instructors aim to draw more students to science.
Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy
Recent advances in nanomedicine have facilitated the development of potent nanomaterials with intrinsic enzyme-like activities (nanozymes) for cancer therapy. However, it remains a great challenge to fabricate smart nanozymes that precisely perform enzymatic activity in tumor microenvironment without inducing off-target toxicity to surrounding normal tissues.
Defect passivation by alcohol-soluble small molecule for efficient p-i-n planar perovskite solar cells with high open-circuit voltage
Defect passivation by alcohol-soluble small molecule for efficient p-i-n planar perovskite solar cells with high open-circuit voltage Kang Chen, Jingnan Wu, yanan wang, Qing Guo, Qiaoyun Chen, tiantian cao, Xia Guo, Yi Zhou, Ning Chen, Maojie Zhang and Yongfang Li Abstract Solution-processed perovskite films inevitably have a number of ionic defects, regarded as non-radiative recombination center, which limits the overall efficiency and the stability of perovskite solar cells (Pero-SCs).
All-Polymer Solar Cells Based on A Novel Narrow-Bandgap Polymer Acceptor with Power Conversion Efficiency Over 10%
All-Polymer Solar Cells Based on A Novel Narrow-Bandgap Polymer Acceptor with Power Conversion Efficiency Over 10% In this work, a novel narrow-bandgap conjugated polymer acceptor (PN1) based on an electron-withdrawing 3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone))-5,5,11,11-tetrakis[3-((2-hexyldecyl)oxy)benzene]-dithieno[2,3-d:2’,3’-d’]-s-indaceno[1,2-b:5,6-b’] dithiophene) as core building block and thiophene as linking unit, was developed and applied in all-polymer solar cells...
High Efficient Near-infrared and Semitransparent Polymer Solar Cells Based on an Ultra-Narrow Bandgap Nonfullerene Acceptor
High Efficient Near-infrared and Semitransparent Polymer Solar Cells Based on an Ultra-Narrow Bandgap Nonfullerene Acceptor Juan Chen, Guangda Li, Qinglian Zhu, Xia Guo, Qunping Fan, Wei Ma and Maojie Zhang Abstract The design of narrow band gap (NBG) acceptors and their application in polymer solar cells (PSCs) are critical to the conversion of solar photons to electrons.
A small molecule donor containing non-fused ring core for all-small-molecule organic solar cells with high efficiency over 11%
A small molecule donor containing non-fused ring core for all-small-molecule organic solar cells with high efficiency over 11% Xinxin Li, Yan Wang, Xia Guo, Qinglian Zhu, Wei Ma, Xuemei Ou, Maojie Zhang and Yongfang Li Abstract A novel p-type organic semiconductor (p-OS) P2TBR, based on non-fused ring structure of thiophene-benzene-thiophene (TBT) as core and 2D-conjugated benzodithiophene (BDT) unit as π spacers and 3-ethylrhodanines as terminal groups, was synthesized and used as the donor...
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