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Articles by Xia Yan
Exploratory serum proteomics and independent validation identify SLC3A2 as a candidate biomarker associated with the near-death state
Abstract Accurate prognostication in critically ill patients remains a central challenge. This study aimed to explore serum proteomic changes associated with the near-death state and to evaluate candidate biomarkers. We conducted a two-phase study, beginning with data-independent acquisition mass spectrometry (DIA-MS) on a discovery cohort of patients with acute cerebral infarction (n = 6).
Probabilistic Temperature-Dependent Mechanical Properties of Cold-Formed Steel
Get full access to this article View all available purchase options and get full access to this article. Data Availability Statement Some or all data, models, or code that support the findings of this study are available from the corresponding author upon reasonable request. Author Contributions Xia Yan: Investigation; Methodology; Writing – original draft. Honghui Qi: Investigation; Writing – review and editing. Thomas Gernay: Supervision; Writing – review and editing.
Strong electromagnetically induced transparency effect constructed by quasi-BIC and Brillouin zone folding GMR in composite dielectric metasurfaces
Traditional electromagnetically induced transparency (EIT) typically exhibits low quality (Q) factors and limited tunability. Bound states in the continuum (BIC) offer a promising solution for achieving high-Q EIT. In this work, we engineer a high-Q EIT resonance on a silicon-membrane metasurface by coupling a quasi-BIC with a Brillouin zone folding guided mode resonance (BZF-GMR).
[2512.03113] A Discrete Neural Operator with Adaptive Sampling for Surrogate Modeling of Parametric Transient Darcy Flows in Porous Media
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A Neutrosophic d-Algebraic Framework for Modeling Psychological Education Modes of College Students in the Big Data Era
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Evaluation of Operational Efficiency in China’s Pharmaceutical Industry and Analysis of Environmental Impacts
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Complexity of the lichen symbiosis revealed by metagenome and transcriptome analysis of Xanthoria parietina
Keywords lichens, symbiosis secretome effectors metagenomics metatranscriptomics NLRs Introduction Symbiosis is one of the most widespread and successful lifestyle strategies for biological organisms.
Application of the Omaha System-Based Continuous Care Model in Diabetes Health Management for Outpatients within the Framework of “Internet +”
Introduction Type 2 diabetes mellitus (T2DM), characterized by chronic hyperglycemia, encompasses a group of metabolic disorders that progressively damage various tissues, posing significant risks to individuals and society (Shahrestanaki et al, 2024). T2DM is the third most prevalent non-communicable disease in developed nations, following cardiovascular diseases and cancer, and represents a global public health challenge of considerable magnitude (Sun et al, 2022).
The blast effector Pwl2 is a virulence factor that modifies the cellular localisation of host protein HIPP43 to suppress immunity.
Abstract The rice blast fungus Magnaporthe oryzae secretes a battery of effector proteins to facilitate host infection. Among these effectors, Pwl2 was first identified as a host specificity determinant for infection of weeping lovegrass (Eragrostis curvula) and is also recognised by the barley Mla3 resistance gene. However, its biological activity is not known. Here we show that PWL2 expression is regulated by the Pmk1 MAP kinase during cell-to-cell movement by M.
Flavonoid Synthesis Pathway Response to Low-Temperature Stress in a Desert Medicinal Plant, Agriophyllum Squarrosum (Sandrice)
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Phylogeographic analysis reveals multiple origins of the desert shrub Reaumuria songarica in northern Xinjiang, involving homoploid and tetraploid hybrids
1 INTRODUCTION Hybridization between or within species is common in nature and has been recognized as an important driver of evolution and speciation (Abbott et al., 2013; Barton, 2001; Mallet, 2007). In the plant kingdom, the proportion of species involved in hybridization and introgression is estimated to be as high as 25% (Mallet, 2005).
Multipartite complexity of the lichen symbiosis revealed by metagenome and transcriptome analysis of Xanthoria parietina
Abstract Lichens are composite symbiotic associations of fungi, algae, and bacteria that result in large, anatomically complex organisms adapted to many of the world's most challenging environments. How such intricate, self-replicating lichen architectures develop from simple microbial components remains unknown because of their recalcitrance to experimental manipulation.
Evaluating the persuasive influence of political microtargeting with large language models | Proceedings of the National Academy of Sciences
Significance Advances in large language models (LLMs) have raised concerns over scalable, personalized political persuasion. Here, we integrate user data into GPT-4 prompts in real-time, facilitating the live creation of messages tailored to persuade individual users on political issues. We then deploy this application at scale to test whether personalized, microtargeted messaging offers a persuasive advantage compared to nontargeted messaging.
The role of mitochondria in sex- and age-specific gene expression in a species without sex chromosomes | Proceedings of the National Academy of Sciences
Significance Mitochondrial functions require coordinated interactions with products encoded by the nuclear genome. Given the central role in adenosine triphosphate production, mitochondrial effects are expected to differ between sexes and across ages. We measured sex- and age-specific effects of mitochondria in single individuals of a species without sex chromosomes.
TULIP: A transformer-based unsupervised language model for interacting peptides and T cell receptors that generalizes to unseen epitopes | Proceedings of the National Academy of Sciences
TULIP: A transformer-based unsupervised language model for interacting peptides and T cell receptors that generalizes to unseen epitopes Edited by David Weitz, Harvard University, Cambridge, MA; received September 20, 2023; accepted April 29, 2024 Significance T cells recognize pathogens by binding their peptides through specific and diverse receptors.
OGA mutant aberrantly hydrolyzes O-GlcNAc modification from PDLIM7 to modulate p53 and cytoskeleton in promoting cancer cell malignancy | Proceedings of the National Academy of Sciences
OGA mutant aberrantly hydrolyzes O-GlcNAc modification from PDLIM7 to modulate p53 and cytoskeleton in promoting cancer cell malignancy Chia-Wei Hu, Ao Wang https://orcid.org/0000-0001-9560-9422, Dacheng Fan, +6 , Matthew Worth, Zhengwei Chen, Junfeng Huang, Jinshan Xie https://orcid.org/0000-0003-4675-6965, John Macdonald, Lingjun Li https://orcid.org/0000-0003-0056-3869, and Jiaoyang Jiang https://orcid.org/0000-0001-8445-9924 jiaoyang.jiang@wisc.edu -6Authors Info & Affiliations Edited by...
A driven Kerr oscillator with two-fold degeneracies for qubit protection | Proceedings of the National Academy of Sciences
A driven Kerr oscillator with two-fold degeneracies for qubit protection Edited by J.C. Davis, University of Oxford, Oxford, United Kingdom; received July 3, 2023; accepted March 1, 2024 Significance In the quantum world, it seems there is always a path to escape from a trap, thanks to quantum tunneling. However, counterintuitively, if a second path is also available, the two paths can be arranged so that they destructively interfere with each other, thus blocking the escape.
Deception abilities emerged in large language models | Proceedings of the National Academy of Sciences
Significance This study unravels a concerning capability in Large Language Models (LLMs): the ability to understand and induce deception strategies. As LLMs like GPT-4 intertwine with human communication, aligning them with human values becomes paramount. The paper demonstrates LLMs’ potential to create false beliefs in other agents within deception scenarios, highlighting a critical need for ethical considerations in the ongoing development and deployment of such advanced AI systems.
On the engulfment of antifreeze proteins by ice | Proceedings of the National Academy of Sciences
On the engulfment of antifreeze proteins by ice Edited by Valeria Molinero, The University of Utah, Salt Lake City, UT; received December 4, 2023; accepted April 16, 2024 Significance Antifreeze proteins (AFPs) enable the survival of diverse organisms in frigid environments. Present in trace concentrations, AFPs suppress ice formation by binding to ice crystals and inhibiting their growth. The figure of merit of an AFP is the highest supercooling, ΔT∗, for which it can resist engulfment by ice.
Pleiotropy of positive selection in ancient ACE2 suggests an alternative hypothesis for bat-specific adaptations to host coronaviruses | Proceedings of the National Academy of Sciences
Pleiotropy of positive selection in ancient ACE2 suggests an alternative hypothesis for bat-specific adaptations to host coronaviruses Edited by John Speakman, Chinese Academy of Sciences, Shenzhen, China; received December 15, 2023; accepted April 30, 2024 Abstract Angiotensin-convertingenzyme 2 (ACE2) has dual functions, regulating cardiovascular physiology and serving as the receptor for coronaviruses.
Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry | Proceedings of the National Academy of Sciences
Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry Edited by Michelle R.
The racial composition of road users, traffic citations, and police stops
K. Russell, Driving While Black: Corollary phenomena and collateral consequences. Boston Coll. Law Rev. 40, 717–731 (1998). S. Geiger-Oneto, S. Phillips, Driving While Black: The role of race, sex, and social status. J. Ethn. Crim. Justice 44, 709–738 (2003). P. Warren, D. Tomaskovic-Devey, W. Smith, M. Zingraff, M. Mason, Driving While Black: Bias processes and racial disparity in police stops. Criminology 44, 709–738 (2006). K. J. Novak, M. B.
Ionizing radiation exposure on Arrokoth shapes a sugar world | Proceedings of the National Academy of Sciences
Ionizing radiation exposure on Arrokoth shapes a sugar world Edited by Imke de pater, University of California, Berkeley, CA; received November 17, 2023; accepted April 18, 2024 by Editorial Board Member Michael Manga Significance The flyby of the New Horizons spacecraft of the Kuiper Belt Object Arrokoth revealed its reddish appearance and unraveled the unexpected presence of a methanol-rich surface.
Impulsivity is a stable, measurable, and predictive psychological trait | Proceedings of the National Academy of Sciences
Impulsivity is a stable, measurable, and predictive psychological trait Edited by Elke Weber, Princeton University, Princeton, NJ; received December 19, 2023; accepted April 12, 2024 Significance Impulsivity is a personality trait associated with many behaviors in clinical and nonclinical contexts. Serious doubts, however, have been raised on impulsivity as a valid psychological construct, let alone a personality trait.
Do digital technologies reduce racially biased reporting? Evidence from NYPD administrative data
S. Anwar, H. Fang, An alternative test of racial prejudice in motor vehicle searches: Theory and evidence. Am. Econ. Rev. 96, 127–151 (2006). R. J. Lundman, R. L. Kaufman, Driving while black: Effects of race, ethnicity, and gender on citizen self-reports of traffic stops and police actions. Criminology 41, 195–220 (2003). A. Gelman, J. Fagan, A. Kiss, An analysis of the New York City police department’s “stop-and-frisk” policy in the context of claims of racial bias. J. Am. Stat. Assoc. 102, 813–823 (2007). R. G.
A call for open science in forensics
P. A. David, The historical origins of "Open Science": An essay on patronage, reputation and common agency contracting in the scientific revolution. Capital. Soc. 3, 1–106 (2008). National Academies of Sciences, Engineering, and Medicine, Open Science by Design: Realizing a Vision for 21st Century Research (National Academies Press, Washington D.C., 2018). Institute of Medicine, Sharing Clinical Trial Data: Maximizing Benefits, Minimizing Risks (National Academies Press, Washington D.C., 2015). B.
New Diterpenes and Diterpene Glycosides with Antibacterial Activity from Soft Coral Lemnalia bournei
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Recent advances in the extraction, synthesis, biological activities, and stabilisation strategies for β‐carotene: a review
Conflict of interest Authors declare no conflict of interest. References & (2020). Pre-treatment with beta carotene gives protection against nephrotoxicity induced by bromobenzene via modulation of antioxidant system, pro-inflammatory cytokines and pro-apoptotic factors. Applied Biochemistry and Biotechnology, 190, 616–633. , & (2022). Disease prevention and treatment using β-carotene: the ultimate provitamin a. Revista Brasileira de Farmacognosia, 32, 491–501. , & (2022).
Antimicrobial resistance, virulence genes profiles and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae strains from captive giant pandas (Ailuropoda melanoleuca)
Abstract This study aimed to investigate the antibiotic susceptibility, antibiotic resistance genes (ARGs), mobile genetic elements (MGEs), virulence genes, and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) strains isolated from giant pandas. The screening of 178 nonduplicated Klebsiella pneumoniae strains identified eight CRKP strains, with the most abundant ARGs observed in ampC/blaDHA, blaSHV-01, blaSHV-02, tetB-01, tetB-02, tetC-01, and tetC-02.
The blast effector Pwl2 is a virulence factor that modifies the cellular localisation of host protein HIPP43 to suppress immunity.
Abstract The rice blast fungus Magnaporthe oryzae secretes a battery of effector proteins during host infection to suppress plant immunity and promote disease. Among these effectors, the MAX effector-Pwl2 was first identified as a host specificity determinant for infection of weeping lovegrass (Eragrostis curvula). However, its biological activity has remained unknown. Here we show that the PWL2 gene is ubiquitous in all host-limited forms of M.
Anisotropic continuum framework of coupled gas flow - adsorption - deformation in sedimentary rocks
CONFLICT OF INTEREST STATEMENT The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. REFERENCES 1, , . Rock physics of sand-shale mixtures: Classifications, theoretical formulations and study on real dataset. Mar Pet Geol. 2021; 134:105366. doi:10.1016/j.marpetgeo.2021.105366 2, , , .
Effector‐triggered susceptibility by the rice blast fungus Magnaporthe oryzae
I Introduction The filamentous ascomycete fungus Magnaporthe oryzae (synonym of Pyricularia oryzae) threatens global food security by causing devastating blast diseases on rice, millets, and most recently wheat (Gladieux et al., 2018; Asibi et al., 2019; Valent et al., 2020). In rice alone, the fungus causes losses of c. 10–30% of the global rice production (Nalley et al., 2016).
Zinc-finger (ZiF) fold secreted effectors form a functionally diverse family across lineages of the blast fungus Magnaporthe oryzae.
Abstract Filamentous plant pathogens deliver effector proteins into host cells to suppress host defence responses and manipulate metabolic processes to support colonization. Understanding the evolution and molecular function of these effectors provides knowledge about pathogenesis and can suggest novel strategies to reduce damage caused by pathogens.
Duplication and neofunctionalization of a horizontally-transferred xyloglucanase as a facet of the red queen co-evolutionary dynamic
Abstract Oomycetes are heterotrophic protists that share phenotypic similarities with fungi, including the ability to cause plant diseases, but branch in a separate and distant region of the eukaryotic tree of life. It has been suggested that multiple horizontal gene transfers (HGTs) from fungi-to-oomycetes contributed to the evolution of plant-pathogenic traits. These HGTs are predicted to include secreted proteins that degrade plant cell walls.
Genomic analysis of Coccomyxa viridis, a common low-abundance alga associated with lichen symbioses
Abstract Lichen symbiosis is centered around a relationship between a fungus and a photosynthetic microbe, usually a green alga. In addition to their main photosynthetic partner (the photobiont), lichen symbioses can contain additional algae present in low abundance. The biology of these algae and the way they interact with the rest of lichen symbionts remains largely unknown. Here we present the first genome sequence of a non-photobiont lichen-associated alga.
Plant immunity suppression by an exo-β-1,3-glucanase and an elongation factor 1α of the rice blast fungus - Nature Communications
Abstract Fungal cell walls undergo continual remodeling that generates β-1,3-glucan fragments as products of endo-glycosyl hydrolases (GHs), which can be recognized as pathogen-associated molecular patterns (PAMPs) and trigger plant immune responses. How fungal pathogens suppress those responses is often poorly understood. Here, we study mechanisms underlying the suppression of β-1,3-glucan-triggered plant immunity by the blast fungus Magnaporthe oryzae.
First Isolation and Identification of Aeromonas veronii in a Captive Giant Panda (Ailuropoda melanoleuca)
2. Materials and Methods 2.1. Organ Sampling and Bacterial Isolation One dead captive one-day-old giant panda cub with no clinical symptoms was sampled in 2020, in Sichuan province, China. Brittle texture of liver and spleen, dark red liver with hemorrhagic spots and flatulence, pulmonary congestion and hemorrhage, pericardial effusion were found in autopsy. The heart, liver, lung, and kidney were collected for bacterial examination as a routine check.
Material Constants of Anisotropic Poroelasticity and Its Impacts on Shale Gas Production
While the production of shale gas is always accompanied by stratum deformation, previous studies have commonly assumed isotropy to simplify the modeling process despite substantial experimental evidence supporting the anisotropy of these formations. This work contributes to both theoretical and practical aspects of anisotropy. For the theoretical aspect, a novel mixture theory approach is used to explore the poromechanical constants of anisotropic poroelasticity.
Insects | Free Full-Text | Multifunctionality of Jasmonic Acid Accumulation during Aphid Infestation in Altering the Plant Physiological Traits That Suppress the Plant Defenses in Wheat Cultivar XN979
1. Introduction Common wheat ( Triticum aestivum L.) is one of the most widely cultivated plants in the world; however, its production is often threatened by a variety of wheat pests that seriously affect grain yield and quality [ 1 , 2 ].
Animals | Free Full-Text | Complex of Lauric Acid Monoglyceride and Cinnamaldehyde Ameliorated Subclinical Necrotic Enteritis in Yellow-Feathered Broilers by Regulating Gut Morphology, Barrier, Inflammation and Serum Biochemistry
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Hierarchical Modeling of Hydromechanical Coupling in Fractured Shale Gas Reservoirs with Multiple Porosity Scales
The simulation of gas flow in shale formation has been a major challenge in the oil and gas industry due to related multiscale pore structure and nonlinear coupled processes such as rock deformation.
Simple Three-Coefficient Equation for Temperature-Dependent Mechanical Properties of Cold-Formed Steels
Downloaded 0 times Technical Papers Abstract The objective of this paper is to propose relationships for the reduction in mechanical properties of cold-formed steels at elevated temperature. Predicting the degradation of strength and modulus of cold-formed steels with temperature is critical to enable fire design of cold-formed steel members.
Combined ablation-chemotherapy versus chemotherapy alone for pancreatic cancer with liver metastasis: a propensity score matching study
Xia Yana Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China;b Cancer minimally invasive treatment center, Fudan University Shanghai Cancer Center, Shanghai, Chinahttps://orcid.org/0000-0002-5323-0614View further author information , Zhou-Yu Ninga Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China;b Cancer minimally invasive treatment center, Fudan University Shanghai Cancer Center, Shanghai, ChinaView further author information...
The China Quarterly: Volume 243 - | Cambridge Core
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Site-specific metastases of intrahepatic cholangiocarcinoma and its impact on survival: a population-based study
Xia Yan Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China Departments of Integrative Oncology, Fudan University, Shanghai Cancer Center, Shanghai, PR China , Peng Wang Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China Departments of Integrative Oncology, Fudan University, Shanghai Cancer Center, Shanghai, PR China , , , Litao Xu Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China...
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