Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Xiaofei Wang
Perioperative ivonescimab with or without chemotherapy in resectable non-small cell lung cancer: a phase 2 trial
Abstract Resectable non-small cell lung cancer (NSCLC) carries a high risk of postoperative recurrence, underscoring the need for effective perioperative therapies. This nonrandomized, noncomparative phase 2 trial evaluated neoadjuvant ivonescimab monotherapy (cohort 1) or in combination with chemotherapy (cohort 2), followed by surgery and adjuvant ivonescimab.
[2610.34567] Flexible Estimation of Covariate-Specific Win Ratio for Prioritized Time-to-Event Outcomes
Prioritized time-to-event outcomes arise frequently in clinical studies, where treatment comparisons may be based on a prespecified hierarchy of clinically important outcomes. The win ratio provides a natural summary of treatment benefit for such prioritized outcomes. However, methods for characterizing heterogeneous treatment effects by estimating how the win ratio varies with baseline covariates remain limited in this setting.
A single-nucleus atlas of ligular region uncovers brassinosteroid-driven cell fate transitions controlling leaf angle in maize
Abstract The ligular region is a critical determinant of leaf angle (LA) and plant architecture in maize, yet its developmental mechanisms remain largely unknown. In this study, we generate a comprehensive single-nucleus RNA-seq atlas of the maize ligular region, spanning from leaf primordium through the preligule band (PLB) to the mature stage.
A study on the mechanism by which outdoor sports embodied experiences affect young people's sense of life meaning
Abstract Under the dual influence of digital technology and the fast-paced modern lifestyle, outdoor sports have gradually become an important way to alleviate the anxiety of young people. This study adopts a mixed research method to explore the impact of different types of outdoor sports (fitness and physical training, leisure and entertainment, adventure and off-road exploration, and outdoor expansion training) on the sense of meaning in life of young people.
From AI literacy to AI-integrated inquiry-based science teaching: the serial mediating roles of AI-TPACK and science teaching self-efficacy among Chinese pre-service science teachers
Abstract Introduction: Artificial intelligence (AI) is increasingly being integrated into science education, creating new opportunities for visualization, simulation, data interpretation, inquiry-based learning, and scientific explanation. However, it remains unclear how pre-service science teachers translate AI literacy into the professional knowledge and confidence required for AI-supported inquiry-based science teaching.
Single-neuron connectome of nucleus accumbens
Keywords nucleus accumbens projectome neuronal subtypes input cortex hippocampus single-neuron projectome NAc subregions cortical input hippocampal input Get full text access Log in, subscribe or purchase for full access. References 1. Mogenson, G.J. ∙ Jones, D.L. ∙ Yim, C.Y. From motivation to action: functional interface between the limbic system and the motor system Prog. Neurobiol. 1980; 14:69-97 2.
CD44 variant 9 expression in M2 macrophages enhances gastric cancer progression by modulating the tumor microenvironment
Abstract M2 macrophages constitute a major stromal component of gastric cancer (GC) and actively contribute to tumor progression through angiogenesis, tissue remodeling, and epithelial–mesenchymal transition (EMT).
Biomechanical characterization of human lung bullae using uniaxial tensile tests and CT-derived geometry-specific finite element analysis
Abstract Introduction: Lung bullae are air-filled spaces with thin walls located within the lungs, and they are closely associated with spontaneous pneumothorax. However, quantitative mechanical data on human bullae and subject-specific stress analyses remain sparse. Methods: We performed uniaxial tensile tests on surgically resected human tissues, including 39 bulla specimens and 34 parenchyma specimens, and fitted the nonlinear stress–strain curves using hyperelastic models.
Circulating metabolite biomarkers associated with prostate cancer risk in Black Americans: findings from the Southern Community Cohort Study
Abstract Despite the importance of metabolic reprogramming in prostate cancer initiation and progression, little is known about metabolic features associated with prostate cancer risk among Black Americans. This nested case-control study included 195 incident prostate cancer cases and 379 matched controls, focusing on Black Americans from the Southern Community Cohort Study. Using pre-diagnostic plasma samples, a global, semi-quantitative metabolomics assay was conducted.
Thin-Film Engineering of Artificial Interphases for Lithium Batteries
, , , et al. “Thin-Film Engineering of Artificial Interphases for Lithium Batteries.” Small (2026): e74311. https://doi.org/10.1002/smll.74311 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
Thin-Film Engineering of Artificial Interphases for Lithium Batteries
, , , et al. “Thin-Film Engineering of Artificial Interphases for Lithium Batteries.” Small (2026): e74311. https://doi.org/10.1002/smll.74311 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
Multimodal imaging of gene expression, morphology, and activity of the same neuron
Keywords imaging-based multimodal characterization single-neuron profiling in vivo neuronal activity whole-brain neuronal morphology spatial transcriptomics subcellular RNA localization brain clearing multi-plane two-photon microscope 2cEASI-FISH Get full text access Log in, subscribe or purchase for full access. References 1. Luo, L. ∙ Callaway, E.M. ∙ Svoboda, K. Genetic Dissection of Neural Circuits Neuron. 2008; 57:634-660 2. Zeng, H. What is a cell type and how to define it? Cell.
All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer
|
Abstract Adenosine deaminase acting on RNA 1 (ADAR1) contributes to immunotherapy resistance by suppressing interferon signaling. Therapeutic targeting of ADAR1 has not been achieved to date in clinical settings. Here, we discover all-trans retinoic acid (ATRA) promotes ADAR1 protein degradation in cancer. In addition, ATRA induces PD-L1 and combination of ATRA and PD-1 blockade reprograms tumor microenvironments to unleash antitumor immunity, thereby impeding tumor growth.
By Ching-Fei Li, Yongkun Wei, Heng-Huan Lee, Wei-Chao Chang, Yun Xiong, Yitao Tang, Riyao Yang, Jun Yao, Huamin Wang, Xiaofei Wang, Minghui Liu, Jangho Park, Jie Fu, Ying-Nai Wang, Li-Yuan Bai, Shao-Chun Wang, Jianhua Ling, Yu-Yi Chu, Zhenzhen Xun, Anirban Maitra, Wantong Yao, Dihua Yu, Paul Chiao, Haoqiang Ying, Mien-Chie Hung, Cheng-Wei Chou
|
Nature
Verified
MECP2 mutations disrupt pluripotent stem cell fate through remodeling of the three-dimensional genome
Abstract Mutations in the MECP2 gene are the primary cause of Rett syndrome, yet their mechanistic roles during early developmental stages remain poorly understood. In this study, CRISPR-Cas9 technology was applied to generate three loss-of-function mutations in male induced pluripotent stem cells (iPSCs), namely MECP2del6, MECP2insA, and MECP2insT, each targeting distinct functional domains of MECP2.
Ensemble machine learning algorithms leveraged on serum proteomics for enhanced early detection of ovarian cancer
Abstract Ovarian cancer poses a significant clinical challenge due to its asymptomatic onset and poor prognosis, highlighting the critical need for effective early detection strategies. This study developed a framework that integrates serum proteomic profiling with machine learning algorithms.
IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumors
Abstract Cancer therapeutics frequently fail in clinical trials because of poor therapeutic index (efficacy-to-toxicity ratio). We systematically identified targets likely to have a good therapeutic index, revealing insulin receptor substrate 4 (IRS4) as a dependency in IRS4-expressing cancers.
MYC-bound enhancer RNAs in cis regulate gene transcription and tumorigenesis
Abstract Emerging evidence suggests that MYC binds RNAs, but its functional consequences remain unclear. Here, we integrate multiomics data and reveal that MYC broadly binds enhancer RNAs (eRNAs), which exhibit high cancer- and tissue-specific expression in cancer cell lines and patient tumors.
Learning Mixed Latent Forest Models
Abstract This paper adopts a latent forest model for mixed data analysis. Unlike traditional latent tree model, the adopted model is more flexible with several trees, and observed variables are allowed to appear as internal nodes. This model can capture more complex potential mechanisms behind data. We address the latent structural learning and the parameter estimation for this model.
Revealing the intrinsic ethical vulnerability of aligned large language models
Abstract Large language models (LLMs) represent foundational advances toward artificial general intelligence, yet their alignment with human values via instruction tuning and preference learning achieves only superficial ethical compliance. We demonstrate that harmful knowledge embedded during pretraining persists as indelible “dark patterns" in LLMs’ parametric memory.
A Review of Intelligent Robotic Cluster Systems: Current Status and Future Directions
Robotic cluster systems have attracted sustained interest in both research and industrial contexts, yet existing surveys often focus on individual subtopics and provide limited guidance on system-level engineering integration.
Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer
|
ArticleVolume 7, Issue 2102613Open access Affiliations & Notes 1Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA 3Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 4Department of Genomic Medicine, The University of Texas MD Anderson Cancer...
By Zecheng Yang, Madelaine Theardy, Shuaitong Chen, Yongkun Wei, Mitsunobu Takeda, Yue Zeng, Xiaofei Wang, Jun Yao, Jennifer Li, Prapassorn Thirasastr, Jangho Park, Yangxi Zheng, Long Vien, Khalida Wani, Huamin Wang, Sisi Gao, Tim Heffernan Verified, Lawrence N. Kwong, Ignacio I. Wistuba, Laura Bover, Giulio F. Draetta, Haoqiang Ying, Wantong Yao
|
Cell Reports Medicine
Verified
A Powerful and Self‐Adaptive Weighted Logrank Test
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description sim70390-sup-0001-Supinfo.zipZip archive, 4.4 MB Data S1: Supporting Information. sim70390-sup-0002-code.Rapplication/Rstudio, 5.5 KB Data S2: Supporting Information Code.
Correction to “Time-Lapse Deep Learning for Single-Cell Subcellular Structural Phenotypic Antimicrobial Susceptibility Testing”
Analytical Chemistry Cite this: Anal. Chem. 2026, XXXX, XXX Click to copy citationCitation copied! . This publication is available under these Terms of Use. Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Correction to “Time-Lapse Deep Learning for Single-Cell Subcellular Structural Phenotypic Antimicrobial Susceptibility Testing”
Close message 2026-01-06T08:41:16.511-08:00 We are undergoing scheduled maintenance on Thursday, December 11 to improve user account security. Service Window: ET: Thursday, December 11, 2025 | 6 PM ET User login is currently impacted and unavailable. Service should be restored soon. We apologized for the inconvenience and appreciate your patience while we improve the ACS Publications Platform.
The Risk Prediction Tool for Pacing‐Induced Cardiomyopathy in Right Ventricular Pacing Patients
Background Pacing-induced cardiomyopathy (PICM) is a serious complication associated with right ventricular pacing. This study aims to identify patients at a high risk for PICM and mitigate its incidence by guiding the selection of left bundle branch pacing over right ventricular pacing. Methods Consecutive patients who underwent permanent right ventricular pacing at two centers from January 2013 to December 2022 were retrospectively evaluated.
The Risk Prediction Tool for Pacing‐Induced Cardiomyopathy in Right Ventricular Pacing Patients
Conflicts of Interest All authors disclosed no relevant relationships. Data Availability Statement The participants of this study did not give written consent for their data to be shared publicly, so due to the sensitive nature of the research, supporting data is not available. Supporting Information Filename Description pace70102-sup-0001-FigureS1.pdf109.2 KB Supplementary Figure 1: Selection of key features related to survival by the LASSO regression.
Glymphatic dysfunction in neuromyelitis optica spectrum disorder
Introduction Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) characterized by pathogenic autoantibodies directed against aquaporin-4 (AQP4-IgG) (1).
Optimization of Architectural Interior Design Parameters Based on Environmental Dynamic Heat Dissipation Principle and Thermal Comfort Standard
Bai J., Fan H., Cui S., Wang L., He S., Chen M., and Zheng H., 2024. Experimental study of phase change heat dissipation system based on hydrogen fuel cell. Case Studies in Thermal Engineering 59: 104495. Chen H., Zhang H., Wu S., Liu Y., and Zhong H., 2024. Numerical simulation and optimization design for ventilation and heat dissipation in high-temperature and high-load indoor substations. Case Studies in Thermal Engineering 59: 104502. Fan W., Shi C., Liu W., and Liu Z., 2024.
Time-Lapse Deep Learning for Single-Cell Subcellular Structural Phenotypic Antimicrobial Susceptibility Testing
Abstract Click to copy section linkSection link copied! Antimicrobial resistance (AMR) is a global health concern that complicates the effective treatment of infections, resulting in an increased severity of illness and elevated healthcare costs. Traditional phenotypic antimicrobial susceptibility testing (AST) relies on laborious culturing and interpretation of visible growth, resulting in delays ranging from 24 h to several days.
Integrative analysis of single-neuron projectomes links connectome, transcriptome, and function in the mouse cortex
Keywords connectome single-neuron projectome cortex cortico-cortical connectivity cortical hierarchy basal ganglia calcium imaging spatial transcriptome Neuropixels probe multimodal analysis Get full text access Log in, subscribe or purchase for full access. References 1. Harris, K.D. ∙ Shepherd, G.M.G. The neocortical circuit: themes and variations Nat. Neurosci. 2015; 18:170-181 2. Oh, S.W. ∙ Harris, J.A. ∙ Ng, L. ... A mesoscale connectome of the mouse brain Nature. 2014; 508:207-214 3. Zingg, B.
Targeted therapies in lung cancer: personalizing treatment across the age spectrum
Abstract Lung cancer remains the leading cause of cancer-related mortality, yet current precision oncology approaches remain overwhelmingly tumor-centric, guided by genomic alterations and immune biomarkers, while largely neglecting the profound impact of aging biology on treatment response. While emerging evidence suggests that aging biology can modify therapeutic benefit and toxicity, its clinical integration remains uneven and largely investigational.
Preparation of In‐Situ Multifunctional Silicon Self‐Assembled Molecularly Imprinted Polymers for Selective Extraction of Protein
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description jssc70291-sup-0001-SuppMat.docx760.4 KB Supporting File 1: jssc70291-sup-0001-SuppMat.docx References 1, , , , and , “Theoretical Study and Analytical Performance of a Lysozyme Impedimetric Microsensor Based on a Molecularly Imprinted Chitosan Film,” Sensors and Actuators B: Chemical 339 (2021): 129903, https://doi.org/10.1016/j.snb.2021.129903.
SPAG6 hypermethylation silences a novel tumor suppressor and inhibits renal cell carcinoma progression via PI3K/AKT/mTOR pathway
Loading metrics Open Access Peer-reviewed Research Article Citation: Wu T, Ji X, Yun Y, Wang X, Gan Y, Fan Y, et al. (2025) SPAG6 hypermethylation silences a novel tumor suppressor and inhibits renal cell carcinoma progression via PI3K/AKT/mTOR pathway. PLoS One 20(10): e0333202. https://doi.org/10.1371/journal.pone.0333202 Editor: Yung-Hsiang Chen, China Medical University, TAIWAN Received: July 17, 2025; Accepted: September 10, 2025; Published: October 3, 2025 Copyright: © 2025 Wu et al.
Re: Low‐Dose Hydrocortisone in Cirrhotic Patients With Septic Shock: A Double‐Blind Randomised Placebo‐Controlled Trial
Please review our Terms and Conditions of Use and check box below to share full-text version of article. I have read and accept the Wiley Online Library Terms and Conditions of Use Use the link below to share a full-text version of this article with your friends and colleagues. Learn more.
Evaluating the Safety and Effectiveness of Early Post-Surgery Exercise
Introduction Permanent pacemaker implantation remains a cornerstone therapy for the management of symptomatic bradyarrhythmias and conduction system disorders, particularly in aging populations with increasing prevalence of sinoatrial node dysfunction and atrioventricular block. According to global registry data, over one million pacemakers are implanted annually,1,2 with the majority performed in patients aged over 65 years.
Publisher Correction: Cytoplasmic PXR regulates glucose metabolism by binding mRNAs and modulating their stability - Nature Structural & Molecular Biology
Correction to: Nature Structural & Molecular Biology https://doi.org/10.1038/s41594-025-01614-5, published online 12 August 2025. In the version of the article initially published, in the Fig. 1 legend, “ER” was incorrectly defined as “estrogen receptor” when it should have been “endoplasmic reticulum”. This has now been corrected in the HTML and PDF versions of the article. About this article Wang, X., Wang, Z., Li, S. et al.
Cytoplasmic PXR regulates glucose metabolism by binding mRNAs and modulating their stability - Nature Structural & Molecular Biology
Abstract Pregnane X receptor (PXR) is a nuclear receptor considered to be a master transcription factor of xenobiotic metabolism. Here, using enhanced ultraviolet crosslinking and immunoprecipitation, we show that PXR can bind mRNAs in different cancer cell lines and normal liver tissues. PXR-bound mRNAs include genes related to metabolic reprogramming and lipid metabolism.
Correction: TIGIT antibody with PVR competitive ability enhances cancer immunotherapy and capable of eliciting anti-tumour immune memory - British Journal of Cancer Original
Correction to: British Journal of Cancer https://doi.org/10.1038/s41416-025-03046-w, published online 20 May 2025 In this article the author contribution statement was originally missing; this has now been corrected. The author contribution statement is as follows: These authors contributed equally: Huijuan Yu, Shaowen Jin. The original article has been corrected. About this article Yu, H., Jin, S., Zeng, M. et al.
The Critical Role of APOE+ Macrophages in the Immune Microenvironment and Prognosis of Lung Adenocarcinoma
1 Introduction Lung cancer is one of the most prevalent and deadly malignancies worldwide, with lung adenocarcinoma (LUAD) being its major histological subtype and showing a rising incidence in recent years [1, 2]. Although the optimisation of molecular targeted therapy and chemotherapy regimens has led to survival benefits in some LUAD patients, challenges such as recurrence and drug resistance remain severe, and the overall 5-year survival rate is still low [3, 4].
Single‐Cell Sequencing Reveals That CD4+ T Cells Eliminate Senescent Prostate Epithelium to Delay Progression of Benign Prostatic Hyperplasia
1 Introduction Benign prostatic hyperplasia (BPH) is highly prevalent among aging men, affecting over 50% of those aged 60 and above (Chughtai et al. 2016). This progressive enlargement of the prostate leads to urinary obstruction and a considerable decline in quality of life. Reflecting its impact, BPH had the highest age-standardized incidence rate (ASIR) among urologic diseases in 2021, reaching 5531.88 cases per 100,000 persons (Zi et al. 2024).
Perdeuteration of (Hetero)arenes in Flow Enabled by Defective Porous Carbon
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adsc70037-sup-0001-SuppData-S1.pdf10 MB Supplementary Material Reference 1, Nat. Biotechnol. 2017, 35, 493. 2, , , , , Chem. Eur. J. 2011, 17, 14385. 3, , , , J. Med. Chem. 2019, 62, 5276. 4, , , , , , J. Am. Chem. Soc. 2024, 146, 1224. 5, , , , , Chem. Soc. Rev. 2022, 51, 6291. 6, , , , , , , Nat. Commun. 2020, 11, 4722. 7, , , , , , Nat. Commun. 2022, 13, 5951. 8, , , , , , , Nature 2024, 634, 592. 9, , , J.
Physical Education's Role in Enhancing Fitness Among Children and Adol
Introduction Physical fitness (PF) is widely recognized as a critical biomarker of health status and developmental integrity in children and adolescents.1–3 As a multidimensional construct, PF encompasses cardiorespiratory endurance, muscular strength, muscular endurance, flexibility, and body composition4–6—domains that collectively reflect the functional capacity of the metabolic, musculoskeletal, and neuromotor systems.7,8 Robust epidemiological and experimental evidence has demonstrated...
A model for detecting coal fires using deep learning methods and remote sensing imagery
Advanced search Remote Sensing Letters Volume 16, 2025 - Issue 9 Submit an article Journal homepage Full Article Figures & data References Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/2150704X.2025.2525993?needAccess=true ABSTRACT Coal fires from mining activities cause severe economic, environmental, and safety repercussions, making identification of spontaneous combustion areas essential for monitoring.
Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa
1 Introduction Soil salinity is a pervasive problem affecting agricultural productivity worldwide.
Large language model comparisons between English and Chinese query performance for cardiovascular prevention - Communications Medicine
Abstract Large language model (LLM) offer promise in addressing layperson queries related to cardiovascular disease (CVD) prevention. However, the accuracy and consistency of information provided by current general LLMs remain unclear.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Xiaofei
Contact Xiaofei, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack