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Articles by Xiaoling He
Dynamics of human cardiogenesis and its disruption in trisomy 21
Abstract Developmental dynamics involve the specification of diverse cell types and their spatial organization into multicellular niches1. Here we combine single-cell and spatial multiomics to define 21 distinct tissue niches in the developing heart, which we use to develop a context-aware, resolution-agnostic niche classification tool (TissueTypist). Applying high-resolution spatial profiling to the developing sinoatrial node, we resolve three pacemaker cell subtypes arrayed along a linear axis.
Cell atlas of the developing human meninges reveals a dura-like nature of meningiomas
Abstract The vertebrate central nervous system is enveloped by the meninges, consisting of the pia, arachnoid and dura layers. The arachnoid is hypothesized to give rise to the most common primary intracranial tumours, meningiomas. However, supporting molecular evidence is lacking. There are no effective medical therapies to treat meningiomas that are resistant to local interventions, encumbered by our limited understanding of their cellular origin.
Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics
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Abstract The meninges are increasingly recognized as key stromal and immune niches supporting cranial development. Here we constructed a paired single-nuclei RNA and Assay for Transposase-Accessible Chromatin atlas of human meningeal development from 6 to 21 postconception weeks across cranial regions. By integrating spatial transcriptomics, we resolved cell types across meningeal layers.
By Ken To, J. Patrick Pett, Olli Dufva, Nana-Jane Chipampe, Krzysztof Polanski, Ana-Maria Cujba, Kenny Roberts, Alexander Predeus, Nadav Yayon, Kazumasa Kanemaru, David Horsfall, Pavel V. Mazin, Batuhan Cakir, Rakesh Kapuge, Alicja Wilk, Fani Memi, Xiaoling He, Nita Solanky, Saeed Kayhanian, Richard Mair, Koen Rademaker, Omer Ali Bayraktar, Muzlifah Haniffa, Roger Barker, Christopher Buckley, Sarah A Teichmann
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Nature
Verified
Early α-synuclein–mediated mitochondrial dysfunction in a human cell model of Parkinson’s disease dementia
Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterised by the misfolding and accumulation of α-synuclein (α-syn) into pathological aggregates known as Lewy bodies. PD remains incurable, partly due to limited physiologically relevant models that recapitulate human pathology to enable therapeutic development. We developed a novel in vitro PD dementia model using fetal human cortical neurons seeded with α-syn preformed fibrils (PFFs).
The immunological profile of RC17 hESC-derived dopaminergic neural progenitor cells in vitro: Implications for the STEM-PD clinical trial
Results First, we confirmed successful differentiation of RC17 hESC to mesDAp using the Nolbrant et al. protocol, as used in the STEM-PD trial.
Partitioning Evapotranspiration Using an Optimised Isotopic Technique Under Land Use Change
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References , , , et al. 2012. “Evaporative Loss From Irrigated Interrows in a Highly Advective Semi-Arid Agricultural Area.” Advances in Water Resources 50: 20–30. https://doi.org/10.1016/j.advwatres.2012.07.010. , , , , , and . 2021.
Spatiotemporal cellular map of the developing human reproductive tract - Nature
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Abstract The human reproductive tract is essential for species perpetuation and overall health. Its development involves complex processes of sex specification, tissue patterning and morphogenesis, the disruption of which can cause lifelong issues, including infertility1,2,3,4,5.
By Valentina Lorenzi, Elias R. Ruiz-Morales, Elizabeth Tuck, Kenny Roberts, Marc-Antoine Jacques, James Ashcroft, Xiaoling He, Berta Crespo, Batuhan Cakir, Simon Murray, Alexander Predeus, Martin Prete, Roger Barker, Luz M Garcia-Alonso, John C Marioni, Cecilia Icoresi-Mazzeo, Charlotte Cassie, Ryan Colligan
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Nature
Verified
The relationship between servant leadership and followers’ pro-social rule-breaking behavior: a study based on Chinese selected candidates
1 Introduction The “selected candidates” (a special talent recruitment program within the Chinese civil service system) program constitutes a distinctive selection mechanism within China’s civil service system. It primarily targets outstanding university graduates with the aim of cultivating young cadres who possess strong comprehensive qualities and professional capabilities, thereby building a talent pipeline for government agencies at both national and local levels.
Single-cell transcriptomics identifies chondrocyte differentiation dynamics in vivo and in vitro
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Keywords cartilage single-cell RNA sequencing skeletal development in vitro chondrogenesis Introduction Large-scale single-cell profiling studies have improved our understanding of the cellular composition of multiple organ systems.1 These efforts extend to human development, with profiles of different systems across developmental time providing insight into the origins of a range of diseases.2,3 This knowledge promises to improve the fidelity of in vitro organoid systems, providing both a...
By John Lawrence, Steven Woods, Kenny Roberts, Dinithi Sumanaweera, Petra Balogh, Alexander Predeus, Peng He, Krzysztof Polanski, Elena Prigmore, Elizabeth Tuck, Lira Mamanova, Di Zhou, Simone Webb, Laura Jardine, Xiaoling He, Roger Barker, Muzlifah Haniffa, Adrienne M. Flanagan, Matthew Young Verified, Sam Behjati, Omer A. Bayraktar, Susan J Kimber, Sarah A Teichmann
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Cell Press
Verified
Highly conductive PBFDO-based multifunctional composite for electromagnetic interference shielding, thermal management, and sensing
Highly conductive PBFDO-based multifunctional composite for electromagnetic interference shielding, thermal management, and sensing The development of highly conductive composites hinges critically on the uniform dispersion of conductive fillers within polymer matrices, yet traditional metal-based and carbon-based conductive materials often encounter issues of agglomeration.
Physico‐Chemical Characterization and Antilaryngeal Cancer Effects of the Silver Nanoparticles Green‐Mediated by Malva parviflora L. Extract
References 1, , and , “Cancer Statistics, 2015,” CA: A Cancer Journal for Clinicians 65 (2015): 5–29. 2 and , “A Review on the Classification, Characterisation, Synthesis of Nanoparticles and Their Application,” IOP Conference Series: Materials Science and Engineering 263 (2017): 032019.
The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson’s disease - Nature Biotechnology
Abstract Transplantation of human fetal ventral mesencephalic tissue in individuals with Parkinson’s disease has yielded clinical benefits but also side effects, such as graft-induced dyskinesias. The open-label TransEuro trial (NCT01898390) was designed to determine whether this approach could be further developed into a clinically useful treatment.
A multi-omic atlas of human embryonic skeletal development - Nature
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Abstract Human embryonic bone and joint formation is determined by coordinated differentiation of progenitors in the nascent skeleton. The cell states, epigenetic processes and key regulatory factors that underlie lineage commitment of these cells remain elusive.
By J. Patrick Pett, Kenny Roberts, Raphael Blain, Krzysztof Polanski, Peng He, Chuan Xu, James Cranley, Madelyn Moy, Ruoyan Li, Kazumasa Kanemaru, Stathis Megas, Laura Richardson, Rakesh Kapuge, Batuhan Cakir, Alexander Predeus, Simon Murray, Martin Prete, Pavel V. Mazin, Xiaoling He, Kerstin B Meyer, Muzlifah Haniffa, Roger Barker, Alain Chédotal, Christopher Buckley
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Nature
Verified
A spatial human thymus cell atlas mapped to a continuous tissue axis - Nature
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Abstract T cells develop from circulating precursor cells, which enter the thymus and migrate through specialized subcompartments that support their maturation and selection1. In humans, this process starts in early fetal development and is highly active until thymic involution in adolescence.
By Nadav Yayon, Lena Boehme, Brianna T. Wachter, Oren Amsalem, Alexander Predeus, Catherine Tudor, Francesca Pala, Elena Prigmore, Nana-Jane Chipampe, Martin Prete, Roger Barker, Xiaoling He, Filip Van Nieuwerburgh, Virginie Uhlmann, Luigi D. Notarangelo, Ronald N Germain, Andrea J. Radtke, John C Marioni, Tom Taghon
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Nature
Verified
HOX gene expression in the developing human spine - Nature Communications
Abstract Positional coding along the anterior-posterior axis is regulated by HOX genes, whose 3’ to 5’ expression correlates with location along this axis. The precise utilisation of HOX genes in different human cell types is not fully understood. Here, we use single-cell and spatial-transcriptomics, along with in-situ sequencing, to create a developmental atlas of the human fetal spine.
MXene and Polymer Collision: Sparking the Future of High‐Performance Multifunctional Coatings
Conflict of Interest The authors declare no conflict of interest. References 1, , , , Mater. Chem. Front. 2021, 5, 7134. 2, , , , Chem. Eng. J. 2023, 472, 144801. 3, , , , , , Chem. Soc. Rev. 2020, 49, 6666. 4a) , , , , , , , , Eur. Polym. J. 2022, 167, 111063; b) , , , , , , , , , J. Mater. Chem. A 2021, 9, 14147; c) , , , , , , , , Chem. Soc. Rev. 2020, 49, 7229. 5a) , , , , , J. Mater. Sci. Technol. 2020, 56, 18; b) , , , Chem. Eng. J. 2021, 409, 128099. 6a) , , , , , , , , , , J. Water Process. Eng.
Thin edges in cubic braces
For a vertex set X $X$ in a graph, the edge cut ∂ ( X ) $\partial (X)$ is the set of edges with exactly one end vertex in X $X$ . An edge cut ∂ ( X ) $\partial (X)$ is tight if every perfect matching of the graph contains exactly one edge in ∂ ( X ) $\partial (X)$ . A matching covered bipartite graph G $G$ is a brace if, for every tight cut ∂ ( X ) $\partial (X)$ , | X | = 1 $|X|=1$ or | X ¯ | = 1 $|\bar{X}|=1$ , where X ¯ = V ( G ) ⧹ X $\bar{X}=V(G)\setminus X$ .
Chromatin accessibility during human first-trimester neurodevelopment - Nature
Abstract The human brain develops through a tightly organized cascade of patterning events, induced by transcription factor expression and changes in chromatin accessibility. Although gene expression across the developing brain has been described at single-cell resolution1, similar atlases of chromatin accessibility have been primarily focused on the forebrain2,3,4.
Polyionic liquid ionogels formed via hydrophobic association for flexible strain sensors
Polyionic liquid ionogels formed via hydrophobic association for flexible strain sensors† In recent years, self-healing conductive hydrogels have attracted much attention for their promising applications in flexible electronic devices. However, the development of integral conductive hydrogels with excellent mechanical, self-healing, anti-freezing and strain-sensitive performances remains a major challenge.
Leveraging Cas13a’s trans-cleavage on RNA G-quadruplexes for amplification-free RNA detection
Leveraging Cas13a’s trans-cleavage on RNA G-quadruplexes for amplification-free RNA detection In this study, we investigated Cas13a’s efficacy in trans-cleaving RNA G-quadruplexes (rG4s) as an alternative to ssRNA reporters in CRISPR-Cas13a diagnostics. Our findings demonstrate enhanced efficiency due to the structural arrangement of rG4s.
Frontiers | Exogenous selenium promotes the growth of salt-stressed tomato seedlings by regulating ionic homeostasis, activation energy allocation and CO2 assimilation
WenBo Zhang1, Xiaoling He2, Xianjun Chen3, Han Hongwei4, Bingru Shen5, Ming Diao6* and Huiying Liu7* 1College of Agriculture, Shihezi University, China 2Xiaoling He, China 3Xianjun Chen, China 4Han Hongwei, China 5Bingru Shen, China 6Ming Diao, China 7Huiying Liu, China The final, formatted version of the article will be published soon.
Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells
Antibodies Rabbit polyclonal anti IBA-1 (Wako) Alpha Laboratories Cat#019-19741; RRID: AB_839504 Goat polyclonal anti-Human SOX2 R & D Systems Cat#AF201; RRID: AB_355110 Mouse monoclonal anti-Flavivirus Group Antigen, clone D1-4G2-4-15 Millipore Sigma Cat#MAB10216; RRID: AB_827205 Rabbit monoclonal anti-Flavivirus Group Antigen, clone D1-4G2-4-15 Absolute Antibody Cat#Ab00230-2.0; RRID: AB_2715504 Mouse monoclonal anti-Human Nestin (Clone 196908) Cat#MAB1259; RRID: AB_2251304 Rabbit...
The Choline Metabolite TMAO Inhibits NETosis and Promotes Placental Development in GDM of Humans and Mice
Metabolism Abstract Choline metabolite trimethylamine N-oxide (TMAO) has been recognized as a risk factor of gestational diabetes mellitus (GDM), but its exact role in GDM has not been reported. In this study, we focused on the placenta development to reveal the role of TMAO in GDM. We found that the TMAO levels in peripheral and cord plasma were increased in women with GDM and that TMAO levels were positively correlated with newborn weight and placental thickness.
Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease
Abstract Clinical studies of Parkinson’s disease (PD) using a dopamine cell replacment strategy have been tried for more than 30 years. The outcomes following transplantation of human fetal ventral mesencephalic tissue (hfVM) have been variable, with some patients coming off their anti-PD treatment for many years and others not responding and/or developing significant side effects, including graft-induced dyskinesia.
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