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Xiling Yin

As seen in: Science Magazine, Cell Reports, Cell Stem Cell, Cell Press, Stem Cell Reports, Journal of Infection
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Articles

Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency

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By Byrne M.D, Hu Wang, Xiling Yin, Jinchong Xu
| Stem Cell Reports Verified
Highlights • En1 knockout mice provide a development niche for hESCs to develop into human DA neurons • Human neurons in the mouse brain accumulate pathologic α-synuclein • Optimization of interspecies chimera generation is needed Summary Interspecies chimeras offer great potential for regenerative medicine and the creation of human disease models.
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Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson’s disease

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By Wendi Guo, Kavita Agarwal, Mohammed Repon Khan, Xiling Yin
| Science Magazine Verified
E. R. Dorsey, T. Sherer, M. S. Okun, B. R. Bloem, The emerging evidence of the Parkinson pandemic. J. Parkinsons Dis. 8, S3–S8 (2018). D. L. Manecka, B. Vanderperre, E. A. Fon, T. M. Durcan, The Neuroprotective role of protein quality control in halting the development of alpha-synuclein pathology. Front Mol Neurosci 10, 311 (2017). J. W. Kim, X. Yin, A. Jhaldiyal, M. R. Khan, I. Martin, Z. Xie, T. Perez-Rosello, M. Kumar, L. Abalde-Atristain, J. Xu, L. Chen, S. M. Eacker, D. J. Surmeier, N. T. Ingolia, T. M. Dawson, V. L.
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Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson’s disease

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By Wendi Guo, Kavita Agarwal, Mohammed Repon Khan, Xiling Yin
| Science Magazine Verified
Published In Science Translational Medicine Volume 15 | Issue 724 November 2023 Article versions Submission history Received: 17 May 2022 Accepted: 10 October 2023 Permissions Request permissions for this article. Acknowledgments We thank M. B. Feany (Harvard Medical School) for providing QUAS-SNCA flies, C. J. Potter (Johns Hopkins Medicine) for Syb-QF2 driver flies and pQUAST-att plasmid, and P. Lasko (McGill University) for Drosophila 4EBP antibody. We also thank N. Burgess and I.-H.
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