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Abstract Achieving pancreatic-targeted delivery marks a breakthrough in treating pancreatic diseases, yet precise delivery remains challenging1. Here we identify an explicit and universal principle for pancreatic-selective delivery and propose a pancreatic-targeted lipid nanoparticle (AH-LNP) for mRNA delivery.
1Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310002, China 2National Human Brain Bank for Health and Disease, Zhejiang University, Hangzhou, Zhejiang 310002, China 3School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang 310002, China 4BGI Research, Hangzhou 310030, China 5BGI Research, Shenzhen 518083, China 6College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049,...
The demographics and clinical features of the 23 patients with NTM infection were summarized in Table 1. These patients included 19 (82.6%) men and 4 (17.4%) women, with an age range between 14 and 84 years (median, 60.0 years). The diagnosis of these patients was confirmed by tissue culture (n = 6), non-tuberculous mycobacteria DNA PCR assay (NTM-DNA-PCR) (n = 3), and metagenomic next-generation sequencing (mNGS) (n = 14).
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