Youzhe He

1Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310002, China 2National Human Brain Bank for Health and Disease, Zhejiang University, Hangzhou, Zhejiang 310002, China 3School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang 310002, China 4BGI Research, Hangzhou 310030, China 5BGI Research, Shenzhen 518083, China 6College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049,...

1 INTRODUCTION Alzheimer's disease (AD), commonly known as senile dementia, is a widespread neurodegenerative disorder predominantly associated with aging, typically manifesting after the age of 65 [1]. Currently, over 50 million people worldwide have been diagnosed with AD, it might increase to 150 million by 2050 [2]. Statistics have indicated that nearly two-thirds of all AD patients are females [3].