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Articles by Ya Chen
Yin-Yang: The Dual Role of Lactate as a Context-Dependent Immunometabolic Regulator in the Inflammatory Microenvironment
1 Introduction Inflammation is a highly coordinated biological process that protects the host against pathogens and tissue injury while maintaining immune homeostasis. Beyond the classical regulation by cytokines and immune signalling pathways [1], increasing evidence has established cellular metabolism as a fundamental determinant of immune cell activation, differentiation [2] and functional plasticity [3].
Breaking the Activity–Stability Trade-Off of RuO 2 -Based Electrocatalysts for Proton Exchange Membrane Water Electrolyzer: Modulation Strategies and Mechanism Elucidation
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1, “Sustainable Hydrogen Production,” Science 305 (2004): 972–974, https://doi.org/10.1126/science.1103197.
Immunogenicity, efficacy, and safety of different dose schedules of human papillomavirus vaccines: a Bayesian network meta–analysis of randomized controlled trials
Abstract Background: To enhance global vaccine coverage and reduce costs, Human papillomavirus (HPV) immunization schedules are shifting from the standard three–dose (3D) regimen toward reduced–dose (1D or 2D) schedules. We aimed to evaluate the comparative immunogenicity, efficacy, and safety of diverse dose schedules and vaccine types using a Bayesian network meta–analysis.
Serum Omega-3 Fatty Acids and Obesity-Comorbid Depression in US Adults: An Integrated Epidemiology and Network Pharmacology Study
Accepted manuscript Serum Omega-3 Fatty Acids and Obesity-Comorbid Depression in US Adults: An Integrated Epidemiology and Network Pharmacology Study Published online by Cambridge University Press: 04 August 2026 Ge-Xin Gao Affiliation: School of Nursing, Wenzhou Medical University, Wenzhou, China. Institute of Lipids Medicine, Wenzhou Medical University, Wenzhou, China. En-Yu Lou Affiliation: School of Public Health, Wenzhou Medical University, Wenzhou, China.
DTX3 promotes anti-tumor immunity by inducing PD-L1 ubiquitination and is suppressed by p65/miR-222 in bladder cancer
Abstract The limited efficacy of programmed death ligand-1 (PD-L1)/programmed death 1 (PD-1) immunotherapy remains a major challenge in bladder cancer (BC). Here, we identified Deltex E3 ubiquitin ligase 3 (DTX3) as a negative regulator of PD-L1 expression through whole-exome sequencing (WES) and functional screening. DTX3 overexpression inhibited CD3⁺CD8⁺ T cell apoptosis via the PD-1/PD-L1 axis, increased IFN-γ secretion, and enhanced the anti-tumor effect of anti-PD-1 monoclonal antibody (mAb).
The Favorable Short-Term Efficacy of Preexisting COPD for Extensive-Stage Small-Cell Lung Cancer Receiving Immunotherapy
1 Introduction Lung cancer is the primary cause of mortality in China and around the globe, which often coexists with chronic obstructive pulmonary disease (COPD) [1, 2]. COPD is characterized by progressive airflow limitation and tissue destruction, which has also been a major cause of morbidity, mortality, and health-care use worldwide [3].
Thermally Induced In-Lattice Cation Transformation of 0D Antimony Halides for Improved X-ray Scintillation Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleJuly 6, 2026 Thermally Induced In-Lattice Cation Transformation of 0D Antimony Halides for Improved X-ray Scintillation Click to copy article linkArticle link copied! Le Dong Le Dong College of Electronic and Optical Engineering and College of Flexible Electronics (Future Technology), State Key Laboratory of Flexible Electronics (LoFE), Nanjing University of Posts and Telecommunications, Nanjing 210023, P. R.
Akkermansia muciniphila attenuates intervertebral disc degeneration via extracellular vesicle-mediated delivery of the effector protein B2UKX5
Abstract Low back pain is a leading cause of global disability, with intervertebral disc degeneration (IVDD) as a primary contributor. Emerging evidence suggests a link between gut microbiota and disc health, yet the underlying mechanisms remain unclear. Through Mendelian randomization and a clinical cohort analysis, we identified a causal inverse relationship between Akkermansia muciniphila (Akk) abundance and IVDD risk, with reduced fecal Akk levels correlating with increased IVDD severity.
Bang-bang control optimization in infectious disease model with incorporating breakthrough and reinfection
Abstract Breakthrough infections and reinfection are key factors leading to recurrent epidemic waves. However, sustained control strategies can lead to unnecessary resource wastage when tacking these issues. There is an urgent need to establish dynamic intervention systems capable of rapid response and efficient resource utilization.
Gradient‐Modified Li‐Rich Manganese‐Based Oxides Cathodes with Breakthrough of Kinetic Limitation for High‐Performance All‐Solid‐State Lithium Metal Batteries
1 Introduction All-solid-state lithium batteries (ASSLBs) adopting non-flammable, leak-proof, and explosion-resistant solid electrolytes have garnered widespread attention due to their intrinsic safety, wide operational temperature ranges, and the potential to achieve high energy density [1-4].
Combined serum neurofilament light chain and Tau as biomarkers of diabetic peripheral neuropathy
1 Introduction Diabetes has emerged as one of the most serious global health challenges of the 21st century. According to the 10th edition of the International Diabetes Federation (IDF) Diabetes Atlas, an estimated 537 million adults worldwide were living with diabetes in 2021, and this number is projected to rise to 643 million by 2030 and 783 million by 2045 (1).
Microbacterium salitolerans sp. nov., isolated from saline soil
Volume 76, Issue 1 Article metrics loading... /content/journal/ijsem/10.1099/ijsem.0.007039 Metrics References Orla-Jensen S. The Lactic Acid Bacteria Copenhagen: Høst and Sons; 1919 [Google Scholar] Takeuchi M, Hatano K. Union of the genera Microbacterium Orla-Jensen and Aureobacterium Collins et al. in a redefined genus Microbacterium. Int J Syst Bacteriol 1998; 48 Pt 3:739–747 [View Article] [PubMed] [Google Scholar] Krishnamurthi S, Bhattacharya A, Schumann P, Dastager SG, Tang S-K et al.
Metabolite Identification Data in Drug Discovery, Part 2: Site-of-Metabolism Annotation, Analysis, and Exploration for Machine Learning
Introduction Click to copy section linkSection link copied! Biotransformation can decisively impact the efficacy and safety of small organic molecules, including drugs, cosmetics, and agrochemicals. Many powerful experimental approaches are available today to predict and determine these effects. However, they remain resource and time intensive. Therefore, computational methods for predicting xenobiotic metabolism have gained considerable interest.
Quality Evolution of Turpan Dry Red Wine During Aging Under Controlled Micro‐Oxygenation
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description jfds70468-sup-0001-FigureS1.tiff1.7 MB Supplementary Figure S1: jfds70468-sup-0001-FigureS1.tiff jfds70468-sup-0002-TableS1.xlsx11.1 KB Supplementary Table S1: jfds70468-sup-0002-TableS1.xlsx jfds70468-sup-0003-TableS2.xlsx24 KB Supplementary Table S2: jfds70468-sup-0003-TableS2.xlsx References , , , and . 2002.
ceRNA Profiling Reveals circSAMD4A Promoted Porcine Adipocytes Differentiation via Targeting miR‐127/PRKAR2B
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description asj70072-sup-0001-Suppl_Meterial.docxWord 2007 document , 511.5 KB Table S1. The primers sequence Table S2. circRNAs identified in samples Table S3. Top 15 up- and down-regulated circRNAs Figure S1. Adipocytes differentiation status detection. (A) Adipocytes were stainted with oil red O in Day 6 after inducted differation. (B) Heatmap of FAS, FABP4, PPARγ and HSL in 4 samples.
Study on Synergistic Desulfurization and Chlorine Resistance of Alkaline Metal Oxides@ZrO2/γ‐Al2O3‐Loaded Catalysts
Conflict of Interest The authors declare no conflict of interest. References 1, , , , , , RSC Adv. 2023, 13, 12618. 2, , , , , , , , Appl. Surf. Sci. 2022, 579, 152189. 3, , , , , , , , Inorg. Chem. 2022, 16, 6083. 4, , , , , , , Chemosphere 2022, 307. 5, , , Fuel 2020, 279, 118418. 6, , , , J. Cent. South Univ. 2018, 25, 1920. 7, , , , , , , Fuel 2022, 310, 122335. 8, , , , ISIJ Int. 2019, 59, 590. 9, , , , , , , , New J. Chem. 2021, 45, 3535. 10, , , , , , , , New J. Chem. 2020, 44, 13565.
GAD65 Antibody‐Associated Neurologic Syndrome Overlapping Hemophagocytic Lymphohistiocytosis
Glutamic acid decarboxylase 65 (GAD65) antibody-associated neurologic syndrome is a rare neurologic syndrome mediated by autoimmune response injury including autoimmune epilepsy, autoimmune cerebellar ataxia, stiff-person syndrome, and limbic encephalitis [1]. Hemophagocytic lymphohistiocytosis (HLH) is a systemic inflammatory disease that can present with a variety of clinical manifestations [2]. Both are associated with immunoinflammation, but no coexistence has been reported.
Integrated Virtual Screening Approach Identifies New CYP19A1 Inhibitors
Introduction Click to copy section linkSection link copied! Human aromatase, also known as human CYP19A1, is a member of the cytochrome P450s (CYPs), a superfamily of monooxygenases that contain heme as a prosthetic group and play essential roles in drug metabolism and homeostasis.
Integrated Virtual Screening Approach Identifies New CYP19A1 Inhibitors
Introduction Click to copy section linkSection link copied! Human aromatase, also known as human CYP19A1, is a member of the cytochrome P450s (CYPs), a superfamily of monooxygenases that contain heme as a prosthetic group and play essential roles in drug metabolism and homeostasis.
Reticulated carbon nanofiber-encapsulated SnO2 hollow spheres as high performance anode material for lithium-ion batteries
Reticulated carbon nanofiber-encapsulated SnO2 hollow spheres as high performance anode material for lithium-ion batteries† A novel anode material comprising SnO2 hollow spheres encapsulated within carbon nanofibers (SnO2@CF) is presented for LIBs. The hollow sphere architecture accommodates inward volume changes, while the carbon nanofiber shell mitigates outward volume expansion and enhances electrical conductivity.
Tubular-Specific Expression of HIV Protein Vpr Leads to Severe Tubulointerstitial Damage Accompanied by Progressive Fibrosis and Cystic Development
Keywords Animals, Humans, Mice, AIDS-Associated Nephropathy, Disease Models, Animal, Gene Products, vpr, HIV Infections, HIV-1, Human Immunodeficiency Virus Proteins, Mice, Transgenic, Renal Insufficiency, Chronic, HIV-1 Vpr, renal tubular epithelial cells, proliferation, cell cycle regulation, apoptosis, renal fibrosis, cystic kidney disease Abstract Chronic kidney disease (CKD) is a common cause of morbidity in human immunodeficiency virus (HIV)-positive individuals.
Adenocarcinoma of the rete testis: clinicopathological study of 18 cases with emphasis on MET amplification and a review of the literature
Conflicts of interest The authors declare no potential conflicts of interest. Supporting Information Filename Description his15383-sup-0001-FigureS1.tifTIFF image, 202.3 KB Figure S1. (A) Kaplan–Meier disease-free survival curve for all reported cases, including those in this study. (B) Kaplan–Meier curve showing survival of patients with and without metastasis (log rank P < 0.0001). his15383-sup-0002-FigureS2.tifTIFF image, 4 MB Figure S2. (A) PAX8 expression in the epithelium of rete testis.
A Ratiometric Fluorescent Sensor for the Detection of Norfloxacin in Foods Based on ZIF-8 Core-Shell-Structured Molecularly Imprinted Encoded Microspheres
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The Construction of Multifunctional Solid Electrolytes Interlayers for Stabilizing Li6PS5Cl-based All-Solid-State Lithium Metal Batteries
The Construction of Multifunctional Solid Electrolytes Interlayers for Stabilizing Li6PS5Cl-based All-Solid-State Lithium Metal Batteries The electrochemical performance of all-solid-state Li metal batteries (ASSLMBs) can be prominently consolidated by resolving the challenges triggered by the uncontrolled growth of Li dendrites throughout the solid electrolytes (SEs).
Primary adenocarcinoma of the spermatic cord: a case report and review of the literature - Diagnostic Pathology
References Sogani PC, Grabstald H, Whitmore WF. Jr. Spermatic cord sarcoma in adults. J Urol. 1978;120:301–5. https://doi.org/10.1016/s0022-5347(17)57146-3. Article CAS PubMed Google Scholar Coleman J, Brennan MF, Alektiar K, Russo P. Adult spermatic cord sarcomas: management and results. Ann Surg Oncol. 2003;10:669–75. https://doi.org/10.1245/aso.2003.11.014. Article PubMed Google Scholar Guttilla A, Crestani A, Zattoni F, Secco S, Iafrate M, Vianello F, Valotto C, Prayer-Galetti T, Zattoni F.
Research Progress on Ni‐Based Electrocatalysts for the Electrochemical Reduction of Nitrogen to Ammonia
Conflict of Interests The authors declare no conflict of interest. References 1 and , MRS Bull. 2008, 33, 421. 2, , , , , , , Int. Journal Hydrogen Energ. 2024, 50, 711. 3, , , , , , Nat. Catal. 2019, 2, 290. 4, , , , , , , ACS Sustainable Chem. Eng. 2024, 12, 10313. 5, , , J. Mater. Chem. A 2021, 9, 727. 6J. J. MacKenzie, W. H. Avery, Iecec 96 - Proceedings of the 31st Intersociety Energy Conversion Engineering Conference 1996, 1–4, 1761. 7Y. Q. Guo, Z. F. Pan, L. An, J. Power Sources 2020, 476. 8, , Catal.
Fabrication of Patterned Magnetic Particles in Microchannels and Their Application in Micromixers
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The Ni Heteroatom‐Induced Electronic Structure Tailoring of Ultrastable Fe3N@NCPs Nanosheets Electrocatalyst for Boosting Alkaline Seawater Electrolysis
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202404470-sup-0001-SuppMat.docx15.6 MB Supporting Information References 1, , , , ACS Energy Lett. 2019, 4, 933. 2, , , , , , , , Adv. Mater. Interfaces 2022, 9, 2201486. 3, Electroanal. Chem. 2022, 923, 116805. 4, , , , , Trends Chem. 2021, 3, 485. 5, , , , , Adv. Energy Mater. 2017, 7, 1601275. 6, , , , , , , , , , Adv. Energy Mater. 2016, 6, 1502585. 7, , , , , , , , , , Angew. Chem., Int.
The Ni Heteroatom‐Induced Electronic Structure Tailoring of Ultrastable Fe3N@NCPs Nanosheets Electrocatalyst for Boosting Alkaline Seawater Electrolysis
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202404470-sup-0001-SuppMat.docx15.6 MB Supporting Information References 1, , , , ACS Energy Lett. 2019, 4, 933. 2, , , , , , , , Adv. Mater. Interfaces 2022, 9, 2201486. 3, Electroanal. Chem. 2022, 923, 116805. 4, , , , , Trends Chem. 2021, 3, 485. 5, , , , , Adv. Energy Mater. 2017, 7, 1601275. 6, , , , , , , , , , Adv. Energy Mater. 2016, 6, 1502585. 7, , , , , , , , , , Angew. Chem., Int.
Asymmetric Bond Delta‐Polarization at the Interfacial Se─Ru─O Bridge for Efficient pH‐Robust Water Electrolysis
Conflict of Interest The authors declare no conflict of interest Supporting Information Filename Description adfm202406587-sup-0001-SuppMat.docx20.8 MB Supporting Information References 1a) , , , , , , , , , , , Nat. Catal. 2024, 7, 441; b) , , Nature 2014, 508, 309; c) , , , , , , , Adv. Energy Mater. 2024, 14, 2400059; d) , , , , , , , , , , Small Methods 2023, 7, 2300544. 2a) , , , , , , , , Angew. Chem., Int. Ed. 2022, 61, 202212196; b) , , , , , , , , , , Sci. Adv.
Effects of Rodent Isolation on Plant Community Structure and Greenhouse Gas Emission in the Alpine Grassland of the Qinghai-Tibet Plateau
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Behavioral Sciences | Free Full-Text | Longitudinal Association between Stressful Life Events and Suicidal Ideation in Adults with Major Depression Disorder: The Mediating Effects of Insomnia Symptoms
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Morphological and Molecular Analysis Identified a Subspecies of Crassostrea ariakensis (Fujita, 1913) along the Coast of Asia
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Research Progress on the Layered Metal Oxide Electrocatalysts for Efficient Oxygen Evolution Reaction
Research Progress on the Layered Metal Oxide Electrocatalysts for Efficient Oxygen Evolution Reaction Hydrogen, esteemed for its pristine cleanliness and remarkable efficiency as a burgeoning energy source, is anticipated to ascend to a preeminent status within the forthcoming energy landscape. Electrocatalytic water decomposition is esteemed as a pivotal, eco-conscious, and sustainable avenue for hydrogen acquisition.
Copper/Photoredox‐Catalyzed Regioselective 1,4‐Addition to 1,3‐Enynes: A Convenient Access to Perfluoroalkylated Allenes
Supporting Information Filename Description cjoc202400207-sup-0001-supinfo.pdfPDF document, 7.3 MB Appendix S1: Supporting Information References 1(a) Modern Fluoroorganic Chemistry: Synthesis, Reactivity, Applications, 2nd ed., Wiley-VCH, Weinheim, Germany, 2013; (b) ; ; Fluorine in Pharmaceuticals: Looking Beyond Intuition. Science 2007, 317, 1881–1886.
Effect of electron beam irradiation on raw goat milk: microbiological, physicochemical and protein structural analysis
BACKGROUND Goat milk is considered a nutritionally superior resource, owing to its advantageous nutritional attributes. Nevertheless, it is susceptible to spoilage and the persistence of pathogens. Electron beam irradiation stands as a promising non-thermal processing technique capable of prolonging shelf life with minimal residue and a high degree of automation.
Intensifying the Supported Ruthenium Metallic Bond to Boost the Interfacial Hydrogen Spillover Toward pH‐Universal Hydrogen Evolution Catalysis
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202401452-sup-0001-SuppMat.pdf4.9 MB Supporting Information References 1a) , , , , Nat. Commun. 2018, 9, 2014; b) , , , Nature 2010, 464, 1329; c) , , , , , , , , , , Nat. Commun. 2023, 14, 1711. 2a) , , , , Energy Environ. Sci. 2021, 14, 1722; b) , , , , , , , , , Angew. Chem., Int. Ed. 2023, 62, 202311937; c) , , , , , , , , Small 2023, 19, 2207249. 3a) , , , , , , , , , , Nat. Commun.
Amorphous-Crystalline CoFeB/NiPS3 Vertical Heterostructure with Built-in Electric Field for Robust Ampere-level Water Oxidation.
Amorphous–Crystalline CoFeB/NiPS3 Vertical Heterostructure with Built-in Electric Field for Robust Ampere-level Water Oxidation. Highly efficient oxygen evolution reaction (OER) electrocatalysts play a paramount role in future hydrogen energy deployment. The quest for earth-abundant OER catalysts is actively pursued for the sustainable deployment of water electrolysis.
Dynamic analysis and optimal control of influenza model with discrete age structure
Corresponding Author Juping Zhang Complex Systems Research Center, Shanxi University, Taiyuan, China Shanxi Key Laboratory of Mathematical Techniques and Big Data Analysis on Disease Control and Prevention, Taiyuan, China Key Laboratory of Complex Systems and Data Science of Ministry of Education, Shanxi University, Taiyuan, China Correspondence Juping Zhang, Complex Systems Research Center, Shanxi University, Taiyuan, Shanxi 030006, China. Email: zhangjuping@sxu.edu.cn Communicated by: M.
Faecalibacterium and Others may be able to Predict the Response of Infliximab in Patients with Ulcerative Colitis
Abstract Objective: To explore the impact of IFX on intestinal ecological imbalance in UC and the role of gut microbiota in predicting the response of IFX. Result: The clinical study included 14 patients with moderate to severe active UC who received IFX intervention. Fecal samples of UC patients who reached early clinical remission status during the active phase, after the first IFX intervention, and at 14 weeks were collected for 16S rDNA gene testing and microbial community analysis.
Vascular Endothelial Growth Factor A VEGFA Inhibition: An Effective Treatment Strategy for Psoriasis
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Recent Advances in Non-Targeted Screening of Compounds in Plastic-Based/Paper-Based Food Contact Materials
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Three-Component Cross-Electrophile 1,4-Alkylarylation of 1,3-Enynes by Merging Nickel and Photoredox Catalysis
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