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Articles by Yanming Chen
Integrating Immunogenetics, Single-Cell Transcriptomics, and AI-Assisted Drug Discovery Reveals CXCL10 -Associated Immune Remodelling in Breast Cancer
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The datasets analyzed in this study are publicly available from the Gene Expression Omnibus (GEO) repository under accession numbers GSE42568, GSE65194, GSE70947, GSE10810, and GSE161529. The analytical data and code generated or used during the current study are available from the corresponding author upon reasonable request. References 2025.
Safety and efficacy of human gingiva-derived mesenchymal stem cells in patients with type 1 diabetes: a double-blind, randomized, placebo-controlled, phase 1 trial
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Abstract Current therapies for type 1 diabetes mellitus (T1DM) rarely halt progressive β-cell function loss due to autoimmune attack. Human gingiva-derived mesenchymal stem cells (GMSCs) have been shown to have therapeutic effects on a variety of autoimmune diseases through their potent immunomodulatory capacity, but clinical evidence for these effects is lacking in patients with T1DM.
By Qi Tang, Li Zhou Verified, Liwen Fan, Wei Zhang, Xixiang Tang, Mei Li, Yanhua Zhu, Jia Yuan, Zheng Chen, Song Zheng, Yanming Chen, Donglan Zeng, Mengyin Cai
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Nature
Verified
A septal inhibitory circuit constrains alcohol reward and mediates liraglutide’s suppressive effects on alcohol intake in mice
Keywords alcohol lateral septum LS glucagon-like peptide-1 receptor GLP-1R liraglutide dopamine release inhibitory local circuit Get full text access Log in, subscribe or purchase for full access. References 1. Carvalho, A.F. ∙ Heilig, M. ∙ Perez, A. ... Alcohol use disorders Lancet. 2019; 394:781-792 2. Schuckit, M.A. Alcohol-use disorders Lancet. 2009; 373:492-501 3. Jonas, D.E. ∙ Amick, H.R. ∙ Feltner, C. ...
Attention re-alignment in multimodal large language models via intermediate-layer guidance
Abstract Multimodal large language models (MLLMs) have achieved impressive performance in understanding and describing visual content, setting new state-of-the-art results on a variety of visual question answering (VQA) benchmarks. However, during decoding, these models often fail to attend to fine-grained visual details in the input image.
Staged Effective Medium Modeling and Experimental Validation for Rock Thermal Conductivity
Submitted: 16 February 2026 You are already at the latest version The thermal conductivity (λ) of porous rocks as a function of total porosity, grain size, and fluid saturation is measured and modeled by combining high-precision experiments with a Staged Differential Effective-Medium (SDEM) modeling framework.
Spatial transcriptomics uncovers lipid metabolic dysregulation driving immune-stroma crosstalk in Sjögren's Disease
Keywords Sjögren's disease Salivary gland Lymphoid foci Spatial transcriptomics Metabolism Evidence before this study Previous research has established that Sjögren's Disease (SjD) is characterised by immune-mediated exocrine gland destruction, with prominent T/B-cell hyperactivity and interferon signatures. However, most studies have relied on bulk transcriptomics or single-cell RNA sequencing (scRNA-seq), lacking spatial resolution to delineate tissue-specific immune-stroma interactions.
Correction: Case Report: FGFR1 mutation and massive chromosome loss drive malignant transformation of low-grade gliomas
Affiliation “Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China” was omitted for author “Qing Lan”. This affiliation has now been added for author “Qing Lan”. Author “Qing Lan” was erroneously assigned to affiliation “Department of General Surgery, Children’s Hospital of Soochow University, Suzhou, China”. This affiliation has now been removed for author “Qing Lan”.
Case Report: FGFR1 mutation and massive chromosome loss drive malignant transformation of low-grade gliomas
CASE REPORT article Volume 15 - 2025 | https://doi.org/10.3389/fonc.2025.1694881 Introduction The fibroblast growth factor receptors (FGFR) family of receptor tyrosine kinases plays crucial roles in cell proliferation, apoptosis, and angiogenesis, and is frequently implicated in various types of tumors (1). Somatic FGFR alterations are predominantly found in low-grade astrocytomas and glioneuronal and neuronal tumors.
Synthesis of 2‐Methyl‐1,3‐Propanediol Modified Azelaic Acid‐Octanediol Copolyester Plasticizers and Their Plasticizing Effect on Polyvinyl Chloride
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description app56849-sup-0001-supinfo.docxWord 2007 document , 422 KB Data S1. References 1, , , , and , “Stocks and Flows of Polyvinyl Chloride (PVC) in China: 1980–2050,” Resources, Conservation and Recycling 154 (2020): 104584. 2, PVC Degradation and Stabilization (Elsevier, 2020).
A Novel (AlCrNbTaTi)N Multilayer Hard High-Entropy Alloy Nitride Coating with Variable Aluminum Content Deposited by Cathodic Arc Ion Plating
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Spatial and Temporal Variations in Offshore Crude Oil Transportation: Insights From China's Coastal Ports
Conflicts of Interest The authors declare no conflicts of interest. References , , and . 2017. “Are AIS-Based Trade Volume Estimates Reliable? The Case of Crude Oil Exports.” Maritime Policy & Management 44, no. 5: 657–665. https://doi.org/10.1080/03088839.2017.1309470. , , , and . 2004. “The Architecture of Complex Weighted Networks.” Proceedings of the National Academy of Sciences of the United States of America 101, no. 11: 3747–3752. https://doi.org/10.1073/pnas.0400087101. 2001.
Robustness of a Steel Truss Bridge Subjected to Sudden Member Breakage during the Continuous-to-Simply-Supported Transition
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Innovative Design to Control Spartina Alterniflora
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Anti-Ice PMMA Surface Design and Processing
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Association of weight-adjusted waist index with all-cause mortality among non-Asian individuals: a national population-based cohort study - Nutrition Journal
References Lingvay I, Sumithran P, Cohen RV, le Roux CW. Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation. Lancet. 2022;399(10322):394–405. Article CAS PubMed Google Scholar Jaacks LM, Vandevijvere S, Pan A, McGowan CJ, Wallace C, Imamura F, Mozaffarian D, Swinburn B, Ezzati M. The obesity transition: stages of the global epidemic. Lancet Diabetes Endocrinol. 2019;7(3):231–40. Article PubMed PubMed Central Google Scholar Network GBDC.
Study on non‐isothermal crystallization kinetics of Poly (butylene terephthalate)/Poly (ethylene terephthalateco‐1,4‐cylclohexylenedimethylene terephthalate) blends
CONFLICT OF INTEREST STATEMENT The authors declare that we have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. REFERENCES 1, , , et al. High-performance and functional PBT/EVMG/CNTs nanocomposites from recycled sources by in situ multistep reaction-induced interfacial control. Compos Sci Technol. 2020; 190:108043. 2, , , .
NO and CO Emission Characteristics of Laminar and Turbulent Counterflow Premixed Hydrogen-Rich Syngas/Air Flames
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Salary Prediction Based on the Resumes of the Candidates
SHS Web of Conferences 170, 03013 (2023) Salary Prediction Based on the Resumes of the Candidates 1* and 2 1 Shantou University, Shantou, China 2 Nanyang Technological University, Nanyang, Singapore * Corresponding author: 21ymchen@stu.edu.cn Abstract This paper aims to build a salary prediction model based on the resumes of candidates in a recruitment environment.
A Method for CM EMI Suppression on PFC Converter Using Lossless Snubber with Chaotic Spread Spectrum
5. Results and Discussion A prototype Boost PFC converter was built to verify the accuracy of the theoretical derivation and simulation. The experimental circuit diagram is shown in Figure 10. The prototype is shown in Figure 11. The inductor L of the prototype was measured to be 174 µH. The output capacitor Co was selected to be 2200 µF. The load resistance Rl was selected to be 20 Ω. According to the Application note, the UC3854B was set up with a voltage feedback loop and a current feedback loop.
Rare variability in adrenoleukodystrophy: a case report
A 35-year-old African American man was initially sent to our emergency room to evaluate a possible head trauma after a witnessed fall. He complained of frequent falls and leg weakness for 3–4 months. The weakness appeared to be progressive and persistent without episodic worsening. He had to use a cane to compensate but was still able to ambulate. His family members also endorsed cognitive defects over the past few months before admission.
Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
The fabrication method of micellar nanocrystals described in the present work combines top-down electrospray, bottom-up self-assembly, and solvent-based structure control. An effective and convenient quality control method is to use the Taylor cone formed at the coaxial nozzle tip.
A role for PFKFB3/iPFK2 in metformin suppression of adipocyte inflammatory responses
Metformin improves obesity-associated metabolic dysregulation, but has controversial effects on adipose tissue inflammation. The objective of the study is to examine the direct effect of metformin on adipocyte inflammatory responses and elucidate the underlying mechanisms. Adipocytes were differentiated from 3T3-L1 cells and treated with metformin at various doses and for different time periods.
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