Yannic C. Bartsch
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Immunogenicity of 2 therapeutic mosaic HIV-1 vaccine strategies in individuals with HIV-1 on antiretroviral therapy - npj Vaccines Original
Abstract Mosaic HIV-1 vaccines have been shown to elicit robust humoral and cellular immune responses in people living with HIV-1 (PLWH), that had started antiretroviral therapy (ART) during acute infection. We evaluated the safety and immunogenicity of 2 mosaic vaccine regimens in virologically suppressed individuals that had initiated ART during the chronic phase of infection, exemplifying the majority of PLWH.
Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis
Clinical Perspective Adolescents and young adults who developed myocarditis after severe respiratory syndrome coronavirus disease 2 (SARS-CoV-2) mRNA vaccination display persistently elevated circulating levels of full-length Spike protein, unbound by antibodies. No evidence of autoantibody production, concomitant viral infections, or excessive antibody responses to the anti–SARS-CoV-2 mRNA vaccines was identified in postvaccine myocarditis cases.
Simultaneous analysis of mutations and methylations in circulating cell-free DNA for hepatocellular carcinoma detection
DISCUSSION Most noninvasive cancer detection studies focus on only one type of biomarker because the cfDNA yield is not sufficient to support multiple tests simultaneously. It is challenging to compare the performance of biomarkers profiled in different cohorts from different studies, making it difficult to combine biomarkers to develop a better algorithm for detecting cancer.
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