Yi Xing
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Francis West Lewis Chair; Director, @CHOP_CCGM; Executive Director, @CHOPDBHi; Professor, @Penn. Bioinformatics, RNA Genomics, Human Genetics, Immuno-Oncology.
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Articles by Yi Xing
Shanghai’s GDP Grows 5.5% in First Three Quarters
(Yicai) Oct. 22 -- Shanghai’s economy expanded 5.5 percent in the first three quarters of the year, outpacing the national rate of 4.6 percent, driven by the industrial, financial, and information transmission, software, and information technology sectors. Shanghai’s gross domestic product rose 5.5 percent to CNY4.33 trillion (USD648.8 billion) in the nine months ended Sept. 30 from a year earlier, according to data released by the local statistics bureau today.
China Brings Gear and Technical Standards to ‘Skills Olympics’
(Yicai) Sept. 24 -- China has moved beyond simply competing in the WorldSkills Competition -- a biennial contest often dubbed the “Skills Olympics” -- to having its equipment and technical practices and standards represented in how individual events are conducted.
NanoTS: a deep learning tool for accurate SNP calling in nanopore long-read transcriptome data
Abstract Accurate variant detection using nanopore long-read transcriptome data remains challenging. Here we present NanoTS—a deep learning-based tool for single nucleotide polymorphism detection from diverse types of nanopore transcriptome sequencing data. NanoTS outperforms existing methods, achieving F1 scores above 0.980 and 0.966 on nanopore direct RNA and cDNA sequencing data, respectively, for single nucleotide polymorphisms with at least five supporting reads.
Shanghai Launches Platform to Extend Startup Support Beyond Funding
(Yicai) Aug. 27 -- Shanghai has launched a post-investment services platform to help technology startups backed by state-owned funds access support beyond financing. Managed by Shanghai State‑owned Capital Investment, the new platform has so far brought together more than 100 partners comprising local state‑owned enterprises, universities, research institutes, leading industrial firms, and professional institutions.
Shanghai FTZ's Lingang Special Area to Become Global Hub for Token Services Export
(Yicai) Aug. 20 -- The Lingang Special Area, a key testing ground for economic and trade policies within the Shanghai Free Trade Zone, has set a goal to become a globally influential hub for token services export amid its growing importance in China's digital trade.
Chinese Cultural, Entertainment Firms Speed Global Expansion Through Hong Kong
(Yicai) July 22 -- An increasing number of cultural, creative, sports, and entertainment Chinese mainland companies are leveraging a new specialized institution set up in Hong Kong to help them go global, after the Special Administrative Region government launched the GoGlobal Task Force platform last year.
Beyond gene expression: Single-cell transcriptomics at isoform resolution
Keywords single-cell RNA sequencing long-read RNA sequencing RNA-seq transcriptomics transcript isoform alternative splicing Uncovering single-cell transcriptome heterogeneity at isoform resolution Cells display remarkable heterogeneity that underlies the regulatory and phenotypic complexity of biological systems.
Proceeds of Chinese Mainland, Hong Kong Listings Account for 22% of Global Total in First Half, Report Shows
(Yicai) June 25 -- The amount of funds raised through new listings in the Chinese mainland and Hong Kong markets in the first half of the year accounts for 22 percent of the global total, with one-third of all listings happening in the country, according to an industry report.
Shanghai's Zhangjiang Science City Unveils New Collaboration Platforms to Speed Robotics Industrialization
(Yicai) June 17 -- The Zhangjiang Science City, located in the Shanghai Free Trade Zone, has unveiled a series of robotics industry collaboration platforms, including one related to the embodied intelligence supply chain, to accelerate the industrialization process of the emerging sector.
Lingang Economic Development Sets Up Investment Unit to Bolster Hard Tech Industrial Ecosystem
(Yicai) May 29 -- Industrial park operator Lingang Economic Development Group has established Lingang Innovation Investment & Development to develop the hard tech industrial ecosystem and improve relevant investment in Lingang Special Area, a key testing ground for economic and trade policies within the Shanghai Free Trade Zone.
Shanghai Targets 33% Jump in Service Sector Added Value by 2030
(Yicai) May 27 -- Shanghai aims to raise the added value of its service sector by about 33 percent over the next five years, making the industry a key engine of growth during the 15th Five-Year Plan period through 2030, according to the latest municipal government plan.
Condensed Matter > Soft Condensed Matter
[Submitted on 20 May 2026 ( v1 ), last revised 20 Sep 2026 (this version, v2)] Title:Unifying Plasticity in Ordered and Disordered Matter using Topological and Geometrical Descriptors View a PDF of the paper titled Unifying Plasticity in Ordered and Disordered Matter using Topological and Geometrical Descriptors, by Xin Wang and 7 other authors View PDF HTML (experimental) Abstract:Identifying the regions responsible for plastic flow in amorphous solids remains an open problem, since...
Shanghai Steps Up Push to Become Global Hub Across Five Key Sectors by 2030
(Yicai) May 19 -- Shanghai will go all out to promote the development of five major international centers focused on the global economy, finance, trade and shipping as well as scientific and technological innovation during the 15th Five-Year Plan period, which runs from this year to 2030, the municipal government said.
Cortical and subcortical morphological alterations in de novo GBA -related Parkinson’s disease
Abstract Background: This study aimed to investigate cortical and subcortical changes in GBA-related Parkinson’s disease (GBA-PD) patients and evaluate the ability of these structural changes to identify patients with GBA-PD. Methods: T1-weighted magnetic resonance imaging images were obtained for 86 participants, including 19 GBA-PD, 42 idiopathic PD (iPD) cases, and 25 healthy controls (HCs).
Observed Coworker Helping Behavior and Employees’ Knowledge-Sharing Behavior A Double-Edged Effect from a Third-Party Observer Perspective
1. Introduction As an important form of extra-role behavior in organizations, helping behavior refers to employees’ actions of showing concern for others and assisting them with work-related matters in the workplace [1].
Shanghai Will Step Up Efforts to Implement Plan for Better Business Environment
(Yicai) May 7 -- Shanghai will accelerate efforts to implement a plan to improve the city’s business environment, aiming to ease the burden on companies and clarify services and regulations. The 10 Key Tasks for Optimizing the Business Environment, were based on the ninth version of the plan launched earlier this year.
Analysis and optimized control of dead-time effects in dual active bridge converters to eliminate voltage hazards under high switching frequency
Abstract Dual Active Bridge (DAB) converters are more commonly deployed in renewable energy systems, electric vehicles, advanced energy storage, and distributed power grids than conventional DC-DC converters due to the advantages of electrical isolation, high power density, and zero voltage switching (ZVS) capability.
Global Medical Device Giants Upgrade China Strategies to Advance Local R&D, Production
(Yicai) April 13 -- Foreign medical device companies are adjusting their development strategies for the Chinese market, placing greater emphasis on localized research, development, and production to accelerate cutting-edge product launch and advance local manufacturing.
World’s First Fully HTS Tokamak in Shanghai Holds Steady Operations for 1,337 Seconds
(Yicai) April 1 -- The world’s first fully high-temperature superconducting tokamak operated in Shanghai by local nuclear energy startup Energy Singularity has set a new record for the longest test duration of a nuclear fusion device by a commercial enterprise. Honghuang 70 has recently succeeded in a steady-range long-pulse plasma operation for 1,337 seconds, Energy Singularity announced at a media event yesterday.
Eight Shanghai SOEs Launch AI Agents Contest With 50 Application Scenarios
(Yicai) March 30 -- Eight large state-owned enterprises have kicked off an artificial intelligence competition in Shanghai, opening up 50 application scenarios for AI agents to innovative companies, research institutions, and one-person firms to boost the integration of technology and business.
Shanghai Unveils Lingang Sci-Tech Innovation Hub to Speed Commercialization of Research Achievements
(Yicai) Jan. 22 -- Shanghai has launched the Lingang Science and Technology Innovation City, a project aiming to drive the industrial expansion of scientific research achievements and accelerate the commercialization of cutting-edge research advancements.
Shanghai’s Lingang to Establish Offshore Financial (Economic) Functional Zone to Enhance Openness
(Yicai) Jan. 8 -- Lingang Special Area, a key testing ground for economic and trade policies within the Shanghai Free Trade Zone, will establish an offshore financial (economic) functional zone this year to promote openness in offshore finance.
Shanghai’s Lingang to Roll Out 10 OPC Communities in Three Years to Back Solo Entrepreneurs
(Yicai) Dec. 19 -- Shanghai’s Lingang Special Area will form 10 One Person Company communities in the next three years to provide structured and ecological support for solo entrepreneurs.
Flexible Self‐Powered Photodetector Enabled by TeSeO Amorphous‐Crystalline Hybrid
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description lpor70772-sup-0001-SuppMat.docx7.4 MB Supporting Information: lpor70772-sup-0001-SuppMat.docx.
Sex-specific gray matter underpinnings of anxiety and their mediating mechanisms in de novo Parkinson’s disease
Abstract Objective: Anxiety is a prevalent non-motor symptom in Parkinson’s disease (PD) with observed sex differences. This study aimed to investigate sex-specific gray matter volume (GMV) associations with anxiety and preliminarily explore the potential mediating role of these regional GMV alterations in the relationship between depressive and anxiety symptoms in de novo PD patients. Methods: A total of 108 de novo PD patients were enrolled.
China to Support Shanghai FTZ's Lingang Special Area in Expanding Institutional Openness, Official Says
(Yicai) Nov. 10 -- The Chinese government will go on supporting the Lingang Special Area, a key testing ground for economic and trade policies within the Shanghai Free Trade Zone, in exploring institutional openness, advancing deep reforms and driving high-quality development, according to China's vice commerce minister.
China Joining CPTPP Free Trade Group Will Benefit Global Economy, Officials Say
(Yicai) Nov. 7 -- China's accession to the Comprehensive and Progressive Agreement for Trans-Pacific Partnership will bring economic benefits not only to member countries of the free trade agreement but also to the world, according to officials from the Ministry of Commerce.
Origins and implications of intron retention quantitative trait loci in human tissues
Keywords intron retention irQTL GWAS nonsense-mediated decay NMD eQTL mathematical modeling Introduction Intron retention is a specific class of alternative splicing in which introns are retained in mature RNA transcripts.1,2 Some early studies have suggested that intronic reads may simply be experimental or transcriptional noise.3 However, intron retention has been shown to be involved in a wide range of biological processes, such as development,4,5 disease,6,7 and cancer.8,9 Furthermore,...
Shanghai FTZ's Lingang Special Area to Build Financial Services Ecosystem to Help Chinese Firms Expand Overseas
(Yicai) Oct. 30 -- Lingang Special Area, a key testing ground for economic and trade policies within the Shanghai Free Trade Zone, is developing a super financial services ecosystem to support Chinese companies going global in addressing challenges with overseas financing, exchange rate fluctuations, and slow and inefficient funding.
Chinese AR Glasses Maker Xreal Opens Global HQ in Shanghai
(Yicai) Oct. 29 -- Xreal, a leading Chinese maker of augmented reality glasses, has opened its international headquarters in Shanghai's Pudong New Area to perform research and development, operation, and ecosystem collaboration functions and promote the industry's "iPhone moment." Xreal will use Pudong as its innovation center, promoting the integrated innovation of artificial intelligence and AR technology, it announced yesterday.
Big Emerging Industry Projects Spur Economic Growth in Shanghai's Hongqiao International CBD
(Yicai) Oct. 23 -- The Hongqiao International Central Business District, a center for high-end trade, services, and exhibitions located in western Shanghai, has seen its economic development speed up thanks to an increasing number of large projects in emerging industries. The Hongqiao international CBD saw retail sales of consumer goods rise 18 percent to CNY47 billion (USD6.6 billion) in the nine months ended Sept.
China's Hillhouse, Pudong Venture Capital Launch USD281.4 Million Fund to Build AI Town in Shanghai
(Yicai) Sept. 17 -- The venture capital arm of leading Chinese private equity firm Hillhouse Capital and state-owned Pudong Venture Capital have jointly set up a fund worth CNY2 billion (USD281.4 million) to build an innovation town for 1,000 artificial intelligence companies in Shanghai. The fund, launched by GL Ventures and Pudong Venture Capital, will focus on broad AI technology innovation and AI tech application across various scenarios, according to a press conference held yesterday.
China’s CSSC Science Rises After Bagging Green Methanol Order Worth Up to USD120 Million a Year
(Yicai) Sept. 17 -- Shares of CSSC Science & Technology jumped after the Chinese supplier of wind power equipment said it has secured a client for green methanol from its planned projects, with the deal worth up to USD120 million per year. After jumping by as much as 5.1 percent in Shanghai earlier today, CSSC Science [SHA: 600072] finished 2.4 percent higher at CNY12.67 (USD1.78) a share. The stock has declined almost 10 percent since the end of last year.
Shanghai's Lingang Sci-Tech Innovation City Launches New Rent Relief Project for Startups
(Yicai) Aug. 22 -- The Sci-Tech Innovation City in Lingang Special Area, a key testing ground for economic and trade policies within the Shanghai Free Trade Zone, has launched a new project to provide three-year rent-free office space to startups, one-year rent-free housing for entrepreneurs, and other relevant benefits.
Shanghai’s Yangshan Bonded Zone Kicks Off Digital Upgrade to Boost Business, Cut Costs
(Yicai) Aug. 21 -- Shanghai’s Yangshan Special Comprehensive Bonded Zone launched the construction of its "Digital Comprehensive Bonded Zone" this month, aiming at driving digital transformation across businesses and breaking down data silos between different stakeholders. This shift could cut logistics costs for companies by almost 30 percent, Yicai learned from industry insiders.
Shanghai FTZ's Lingang Area Starts Building Int'l Data Processing Hub, Insiders Say
Shanghai FTZ's Lingang Area Starts Building Int'l Data Processing Hub, Insiders Say audio is not supported! Shanghai FTZ's Lingang Area Starts Building Int'l Data Processing Hub, Insiders Say (Yicai) Aug. 19 -- Lingang Special Area, a key testing ground for economic and trade policies within the Shanghai Free Trade Zone, has begun constructing an International Data Processing Hub by leveraging policy support and institutional innovations, according to several insiders.
Engineered Coenzyme A Biosynthesis and Butyrate Transporter Drives High‐Efficient Butyrate Synthesis in Escherichia coli
Conflicts of Interest This study has been included in patent application by the Tianjin Institute of Industrial Biotechnology. Supporting Information Filename Description bit70018-sup-0001-Supplementary_information.docx152.4 KB Supplementary information. References , , , et al. 2013. “Butyrate Production in Engineered Escherichia coli With Synthetic Scaffolds.” Biotechnology and Bioengineering 110, no. 10: 2790–2794. https://doi.org/10.1002/bit.24925. , , , , , and . 2020.
Shanghai's Lingang Free Trade Area to Invest USD27.7 Million a Year for Tech Startups
(Yicai) May 19 -- Lingang Special Area, a key testing ground for economic and trade policies within the Shanghai Free Trade Zone, will spend around CNY200 million (USD27.7 million) per year to support early-stage technology startups. Lingang also plans to offer various subsidies, such as housing and rental allowances, to attract talents to start businesses or work in the area, its management committee announced on May 16.
M2 Macrophage‐Derived Extracellular Vehicles‐Loaded Hyaluronic Acid‐Alginate Hydrogel for Treatment of Osteoarthritis
ALG alginate hydrogel ALG-CHO aldehyde-modified sodium alginate ALG-M2Exo sodium alginate hydrogel to construct a composite system loaded with M2-Exos Alix ALG-2-interacting protein X Arg-1 arginase-1 BCA bicinchoninic acid CCK-8 cell counting kit-8 CD206 cluster of differentiation 206 CD63 cluster of differentiation 63 CD9 cluster of differentiation 9 COL II collagen type II DAPI 4′,6-diamidino-2-phenylindole DMEM Dulbecco's modified eagle medium ECL electrochemiluminescence EdU...
Shanghai's Pudong New Area, Sino Biopharm Set Up USD136.8 Million Fund for Biopharma Firms
(Yicai) April 23 -- Shanghai's Pudong New Area, which has become a biomedical industry cluster, has linked arms with Chinese drugmaker Sino Biopharmaceutical to set up a fund worth CNY1 billion (USD136.8 million) to meet the financing needs of biopharma companies.
China Should Put More Focus on Homegrown Drug R&D Amid US Tariff Pressure, Academic Says
(Yicai) April 18 -- China needs to step up its efforts in developing cutting-edge new drugs and ramp up domestic production of research equipment to safeguard its industrial supply chains as the US government’s new Reciprocal Tariffs cause havoc in global trade, a scholar from the Chinese Academy of Engineering said.
BASF, Other Foreign Firms Intensify Localization Efforts in China
(Yicai) April 17 -- Several foreign enterprises, including German chemical giant BASF, have further intensified their localization efforts and investments in China amid adjustments in the global economic landscape and increasing uncertainties. The Chinese new energy vehicle sector is developing rapidly thanks to the huge size and enormous potential of its automobile market, making China a worthwhile place for investment, BASF's Vice President Xu Yibin told Yicai yesterday.
Engineering Magnetotactic Bacteria as Medical Microrobots
1 Introduction Micro and nanorobots are small-scale artificial machines capable of performing directed tasks through self-propulsion or external actuation.[1-10] Based on the power source, these modes of locomotion are categorized into chemically, magnetically, optically, ultrasonically, electrically, and biologically driven systems.[11-19] Among these systems, magnetic fields are commonly used for remote controllability, fuel-free biocompatibility, reconfigurability, programmability,...
Japan's Canon Medical Systems Debuts New China Strategy to Expand Local Presence
Japan's Canon Medical Systems Debuts New China Strategy to Expand Local Presence audio is not supported! Japan's Canon Medical Systems Debuts New China Strategy to Expand Local Presence (Yicai) April 10 -- Japanese imaging equipment maker Canon Medical Systems has unveiled its new "Growing Together With Chinese Healthcare" strategy against the backdrop of increased uncertainties in the external economic environment.
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Shanghai's Lingang FTZ to Promote Cross-Border Medical Innovation Services
(Yicai) April 1 -- Lingang Special Area, a key testing ground for economic and trade policies within the Shanghai Free Trade Zone, will actively promote high-level institutional openness and the implementation of cross-border medical innovation service projects. Lingang officially opened a cross-border medical service center and a drug and medical device import-export service center yesterday at an inauguration ceremony held by the local governement.
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AR Glass Business to Drive Shanghai's New Industry Scale to CNY1 Trillion, Xreal's CEO Says
(Yicai) March 28 -- Shanghai's augmented reality glass business is expected to achieve full localization in one to two years, driving the city's new industry scale to CNY1 trillion (USD137.7 billion), according to the chief executive officer of AR glass maker Xreal Technology. "We hope to open up a trillion-Chinese yuan new industry ecosystem in Shanghai's Pudong New Area through AR glasses," Xu Chi said at the 2025 Pudong New Area Investment Promotion Conference yesterday.
Preparation and properties of castor oil-based photothermal dual-responsive DCPNs containing azophenyl groups
Preparation and properties of castor oil-based photothermal dual-responsive DCPNs containing azophenyl groups† A novel castor oil-based reactive monomer containing carboxyl and azobenzene groups named ECODABMNA was prepared. Then, a series of dynamic covalent polymer networks (DCPNs) containing photothermal responsive groups with good mechanical properties were designed and fabricated by curing different epoxy resins (E51, E44 and EBA30) with ECODABMNA as the curing agent.
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