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Yin Shen on Muck Rack

Yin Shen

As seen in: Nature, Wiley Online Library, ScienceDirect, MDPI, Royal Society of Chemistry, BioRxiv, Cell Press, Canadian Journal of Infectious Diseases & Medical Microbiology, Lowyat, Aging and
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Articles

CT-TADB predicts TAD boundaries without Hi-C by integrating DNA sequences and epigenomic features

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By Tong Chen, Shuaibin Wang, Yuan Yuan, Zhen Liang, Yin Shen, Yuyu Jin
| Nature Verified
Abstract Topologically associating domains (TADs) are fundamental units of three-dimensional genome organization, and their boundaries play important roles in gene regulation and genomic stability. However, accurate computational prediction of TAD boundaries remains challenging because of the complex interplay between DNA sequence and epigenomic regulatory signals.
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Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

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By Xiong Wang, Qing Wu, Hao-Long Zeng, Yin Shen
| Wiley Online Library Verified
1 Introduction Chronic stress, such as poverty, chronic somatic illness or enduring social conflicts, is an important risk factor for stress-related disorders such as depression.[1] Approximately 92% of patients with depression encounter stressful events before disease onset.[2] The hypothalamic–pituitary–adrenal (HPA) axis is activated in response to stress, primarily via the steroid hormone cortisol.[3] Chronic cortisol exposure can lead to depression,[4] and ≈20–80% of individuals with...
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DGSAN: Dual-Graph Spatiotemporal Attention Network for Pulmonary Nodule Malignancy Prediction

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By Guanyu Zhou, Yin Shen, Huoling Luo, Zhaojie Fang
| arxiv.org
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