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Fulvestrant versus capecitabine as maintenance therapy in hormone receptor-positive, HER2-negative metastatic breast cancer after first-line chemotherapy (FAMILY): a multicenter, open-label, randomized, phase 3 trial
Abstract Maintenance therapy is key in prolonging remission and improving quality of life for hormone receptor-positive (HR + ), HER-2 negative (HER2-) metastatic breast cancer (MBC), but optimal strategies remain debated.
Epithelial‐Mesenchymal Transition States and Metabolic Reprogramming Related Signatures Predict Prognosis and Therapeutic Responses in HER2‐Positive Breast Cancer
1 Introduction According to the latest global cancer burden data released by the International Agency for Research on Cancer (IARC) of the World Health Organization, the number of new breast cancer cases worldwide reached 2.26 million in 2020, surpassing lung cancer (2.21 million cases) to become the world's largest cancer for the first time [1]. Breast cancer is the most common type of cancer in women, accounting for about 30% of female tumors, and the ratio of mortality to morbidity is 15% [2].
Preclinical study and phase 2 trial of neoadjuvant pyrotinib combined with chemotherapy in luminal/HER2-low breast cancer: PILHLE-001 study
STAR★Methods REAGENT or RESOURCESOURCEIDENTIFIER Antibodies CD163 Abcam RRID: AB_2753196 CD68 Abcam RRID: AB_2801637 PD-1 CST RRID: AB_2864408 PD-L1 CST RRID: AB_2864409 CD3 Dako RRID: AB_2335677 CD4 Abcam RRID: AB_2750883 CD8 Abcam RRID: AB_2756374 CD56 Abcam RRID: AB_2632384 CD20 Dako RRID: AB_3075456 FOXP3 Abcam RRID: AB_445284 pan-CK Abcam RRID: AB_306047 S100 Abcam RRID: AB_882426 Biological samples Tumor samples This study N/A Critical commercial assays QIAamp DNA Mini Kit Qiagen Cat#:...
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