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Yingchi Zhao on Muck Rack

Yingchi Zhao

As seen in: Science Magazine, BioRxiv, Cell Host & Microbe, Cell Reports, The Journal of Biological Chemistry, The Journal of Immunology
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Articles

PM2.5 from Automobile Exhaust Induces Apoptosis in Male Rat Germ Cells via the ROS-UPRmt Signaling Pathway

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By Cao Wang, Yingchi Zhao, Bin Liu, Zhen Luo
| BioRxiv
Abstract Objective: To explore the underlying mechanism behind the fine particulate matter's (PM2.5)-mediated regulation of reproductive function in male rats, and to determine the role of vitamins in this process.
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Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

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By Qirui Guo, Yingchi Zhao, Junhong Li
| Cell Host & Microbe Verified
Highlights ● S100A8 is dramatically up-regulated in SARS-CoV-2 infected animal models and patients. ● A group of aberrant immature neutrophils is induced during SARS-CoV-2 infection. ● Immune disorder is mediated by the S100A8/A9-TLR4 pathway. ● S100A8/A9 inhibitor, Paquinimod, could prevent COVID-19 associated immune disorder. Summary The SARS-CoV-2 pandemic poses an unprecedented public health crisis. Evidence suggests that SARS-CoV-2 infection causes dysregulation of the immune system.
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OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3

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By Zeming Zhang, Dandan Wang, Peiyan Wang, Yingchi Zhao
| The Journal of Immunology Verified
Zeming Zhang, Dandan Wang, Peiyan Wang, Yingchi Zhao and Fuping You J Immunol April 1, 2020, 204 (7) 1904-1918; DOI: https://doi.org/10.4049/jimmunol.1900305 Key Points OTUD1 restricts IRF3 activity in a nonproteolytic manner. OTUD1 deubiquitinates and inhibits DNA binding capacity of IRF3. Virus-induced K6-linked ubiquitination of IRF3 is indispensable for its DNA binding capacity.
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